SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o03'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 2o03 PROBABLE ZINC UPTAKE
REGULATION PROTEIN
FURB
(Mycobacterium
tuberculosis) 		4 / 8 GLU A  35
ARG A  38
ARG A  39
LEU A  19
 None
 0.88A 1cmaA-2o03A:
undetectable
1cmaB-2o03A:
undetectable		 1cmaA-2o03A:
22.73
1cmaB-2o03A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 2o03 PROBABLE ZINC UPTAKE
REGULATION PROTEIN
FURB
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  80
HIS A  82
HIS A 118
 ZN  A 203 (-3.3A)
ZN  A 203 (-3.1A)
ZN  A 203 (-3.3A)
 0.55A 2ozrF-2o03A:
undetectable		 2ozrF-2o03A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 2o03 PROBABLE ZINC UPTAKE
REGULATION PROTEIN
FURB
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 118
HIS A  82
HIS A  80
 ZN  A 203 (-3.3A)
ZN  A 203 (-3.1A)
ZN  A 203 (-3.3A)
 0.53A 3qpkA-2o03A:
undetectable		 3qpkA-2o03A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 2o03 PROBABLE ZINC UPTAKE
REGULATION PROTEIN
FURB
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  80
HIS A  82
HIS A 118
 ZN  A 203 (-3.3A)
ZN  A 203 (-3.1A)
ZN  A 203 (-3.3A)
 0.60A 3qpkB-2o03A:
undetectable		 3qpkB-2o03A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 2o03 PROBABLE ZINC UPTAKE
REGULATION PROTEIN
FURB
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 118
HIS A  82
HIS A  80
 ZN  A 203 (-3.3A)
ZN  A 203 (-3.1A)
ZN  A 203 (-3.3A)
 0.52A 3qpkB-2o03A:
undetectable		 3qpkB-2o03A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2o03 PROBABLE ZINC UPTAKE
REGULATION PROTEIN
FURB
(Mycobacterium
tuberculosis) 		4 / 8 ILE A  16
ILE A  43
THR A  47
THR A  51
 None
 0.76A 4em2A-2o03A:
6.3		 4em2A-2o03A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 2o03 PROBABLE ZINC UPTAKE
REGULATION PROTEIN
FURB
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  80
HIS A  82
HIS A 118
 ZN  A 203 (-3.3A)
ZN  A 203 (-3.1A)
ZN  A 203 (-3.3A)
 0.59A 5migA-2o03A:
undetectable		 5migA-2o03A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 2o03 PROBABLE ZINC UPTAKE
REGULATION PROTEIN
FURB
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 118
HIS A  82
HIS A  80
 ZN  A 203 (-3.3A)
ZN  A 203 (-3.1A)
ZN  A 203 (-3.3A)
 0.46A 5migA-2o03A:
undetectable		 5migA-2o03A:
13.92