SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o04'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		5 / 12 VAL A 152
ILE A 154
VAL A  35
ILE A  58
PHE A 145
 None
 1.16A 1c9hA-2o04A:
undetectable		 1c9hA-2o04A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		5 / 12 GLY A  24
ILE A 266
GLY A 191
SER A 149
ILE A 188
 None
 1.06A 1q8jB-2o04A:
undetectable		 1q8jB-2o04A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		5 / 12 ILE A 154
ILE A 157
PHE A 159
ILE A  58
LEU A  41
 None
 0.92A 1qhsA-2o04A:
undetectable		 1qhsA-2o04A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		5 / 12 ILE A 154
ILE A 157
PHE A 159
ILE A  58
LEU A  41
 None
 0.95A 1qhyA-2o04A:
undetectable		 1qhyA-2o04A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		3 / 3 ILE A 154
ILE A 157
THR A 129
 None
 0.65A 1rg7A-2o04A:
undetectable		 1rg7A-2o04A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		5 / 10 ASP A  12
LEU A   8
GLY A  15
HIS A 269
LEU A 375
 None
 1.36A 1sq5D-2o04A:
undetectable		 1sq5D-2o04A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		4 / 4 ASP A 161
ASP A  63
ASP A 164
GLY A  74
 None
 1.37A 2igtC-2o04A:
undetectable		 2igtC-2o04A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		4 / 5 ILE A 357
LEU A 352
ALA A 359
PHE A 306
 None
 0.76A 2opxA-2o04A:
undetectable		 2opxA-2o04A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		5 / 12 ILE A 147
ILE A  56
THR A 129
LEU A  45
PHE A 145
 None
 1.05A 2qo5A-2o04A:
undetectable		 2qo5A-2o04A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		5 / 9 GLY A 143
GLN A 117
ASP A  63
ILE A  62
VAL A 123
 None
 1.20A 3fi0C-2o04A:
undetectable		 3fi0C-2o04A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		5 / 9 GLY A 143
GLN A 117
ASP A  63
ILE A  62
VAL A 123
 None
 1.23A 3fi0H-2o04A:
undetectable		 3fi0H-2o04A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		5 / 9 GLY A 143
GLN A 117
ASP A  63
ILE A  62
VAL A 123
 None
 1.21A 3fi0K-2o04A:
undetectable		 3fi0K-2o04A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		4 / 5 SER A 316
ILE A 250
GLY A 311
PRO A 281
 None
ADA  A 401 (-4.3A)
None
None
 1.05A 3uboB-2o04A:
undetectable		 3uboB-2o04A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		3 / 3 SER A 211
ASP A 161
ASP A  63
 None
 0.80A 3uj7A-2o04A:
undetectable		 3uj7A-2o04A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		4 / 6 ILE A 186
ARG A 155
MET A 237
THR A 236
 None
 1.19A 3wg7A-2o04A:
undetectable
3wg7J-2o04A:
undetectable		 3wg7A-2o04A:
20.35
3wg7J-2o04A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		4 / 7 ILE A 196
TYR A 242
HIS A 243
VAL A 277
 None
 1.00A 4a97A-2o04A:
undetectable		 4a97A-2o04A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		4 / 7 ILE A 196
TYR A 242
HIS A 243
VAL A 277
 None
 1.07A 4a97D-2o04A:
undetectable		 4a97D-2o04A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		4 / 6 ILE A 196
TYR A 242
HIS A 243
VAL A 277
 None
 0.98A 4a97I-2o04A:
undetectable		 4a97I-2o04A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		4 / 6 THR A 236
HIS A 289
HIS A 376
TYR A 291
 None
 1.34A 4df2A-2o04A:
undetectable		 4df2A-2o04A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		3 / 3 SER A 211
ASP A 161
ASP A  63
 None
 0.79A 4mwzA-2o04A:
undetectable		 4mwzA-2o04A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		5 / 7 ILE A 186
PHE A 201
ARG A 155
MET A 237
THR A 236
 None
 1.27A 5b3sN-2o04A:
undetectable
5b3sW-2o04A:
undetectable		 5b3sN-2o04A:
20.35
5b3sW-2o04A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		5 / 12 VAL A 152
ILE A 154
VAL A  35
ILE A  58
PHE A 145
 None
 1.17A 5hkgA-2o04A:
undetectable		 5hkgA-2o04A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		4 / 6 ARG A 206
GLY A 142
ASP A 161
ASP A  63
 None
 0.86A 5hp1A-2o04A:
undetectable		 5hp1A-2o04A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		3 / 3 GLY A 224
ASP A 184
ASN A 189
 CA  A 402 ( 4.6A)
CA  A 402 (-2.1A)
None
 0.63A 5jglA-2o04A:
undetectable		 5jglA-2o04A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		5 / 12 GLY A 394
ASN A 240
ASN A 202
PHE A 159
ASN A 185
 None
 1.22A 5kc4E-2o04A:
undetectable		 5kc4E-2o04A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		5 / 12 SER A 360
ALA A 333
VAL A 338
GLY A 313
SER A 316
 None
 0.99A 5kirB-2o04A:
undetectable		 5kirB-2o04A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		5 / 12 ILE A 266
PRO A 281
LEU A 268
PHE A 251
GLY A 252
 None
 1.05A 5l6eA-2o04A:
undetectable		 5l6eA-2o04A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		4 / 6 TYR A 163
ASP A 184
HIS A 245
TYR A 219
 None
CA  A 402 (-2.1A)
None
None
 1.19A 5ov9A-2o04A:
undetectable		 5ov9A-2o04A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		4 / 7 TYR A 163
ASP A 184
HIS A 245
TYR A 219
 None
CA  A 402 (-2.1A)
None
None
 1.19A 5ov9B-2o04A:
undetectable		 5ov9B-2o04A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		4 / 6 ASN A 144
ALA A 162
VAL A 121
ASP A 184
 None
None
None
CA  A 402 (-2.1A)
 1.15A 5umd2-2o04A:
undetectable
5umdF-2o04A:
undetectable		 5umd2-2o04A:
12.21
5umdF-2o04A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		3 / 3 GLY A 142
ASN A  65
ARG A 206
 None
 0.68A 5w7bD-2o04A:
undetectable		 5w7bD-2o04A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		5 / 8 ILE A 186
PHE A 201
ARG A 155
MET A 237
THR A 236
 None
 1.27A 5zcpN-2o04A:
undetectable
5zcpW-2o04A:
undetectable		 5zcpN-2o04A:
20.35
5zcpW-2o04A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		4 / 6 ASN A 293
TYR A 291
VAL A 288
THR A 267
 None
 1.41A 6f32B-2o04A:
undetectable		 6f32B-2o04A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 2o04 PECTATE LYASE
(Bacillus
subtilis) 		3 / 3 TYR A 183
ASP A 223
GLN A 182
 None
CA  A 404 (-2.2A)
None
 0.84A 6g1pA-2o04A:
undetectable		 6g1pA-2o04A:
22.63