SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o08'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 2o08 BH1327 PROTEIN
(Bacillus
halodurans) 		4 / 8 ASP A  51
HIS A  50
HIS A 109
HIS A  21
 FE  A 401 (-2.6A)
FE  A 400 (-3.3A)
FE  A 401 (-3.4A)
FE  A 400 ( 3.3A)
 0.64A 1ei6D-2o08A:
undetectable		 1ei6D-2o08A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 2o08 BH1327 PROTEIN
(Bacillus
halodurans) 		5 / 6 HIS A  50
HIS A  21
HIS A  83
HIS A 109
ASP A 127
 FE  A 400 (-3.3A)
FE  A 400 ( 3.3A)
FE  A 401 ( 3.4A)
FE  A 401 (-3.4A)
FE  A 400 ( 2.7A)
 1.18A 1fweC-2o08A:
undetectable		 1fweC-2o08A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 2o08 BH1327 PROTEIN
(Bacillus
halodurans) 		5 / 10 LEU A  32
ALA A  43
LEU A 119
LEU A 118
ILE A 153
 PG4  A 503 (-4.7A)
None
None
None
None
 1.10A 1pcgA-2o08A:
undetectable		 1pcgA-2o08A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 2o08 BH1327 PROTEIN
(Bacillus
halodurans) 		6 / 11 SER A 117
LEU A 125
ILE A 153
GLY A 112
LEU A  32
LEU A 118
 None
None
None
None
PG4  A 503 (-4.7A)
None
 1.15A 2qmmA-2o08A:
undetectable
2qmmB-2o08A:
undetectable		 2qmmA-2o08A:
21.23
2qmmB-2o08A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2o08 BH1327 PROTEIN
(Bacillus
halodurans) 		4 / 8 HIS A 109
ASP A 127
HIS A  83
ASP A  51
 FE  A 401 (-3.4A)
FE  A 400 ( 2.7A)
FE  A 401 ( 3.4A)
FE  A 401 (-2.6A)
 0.99A 2xadA-2o08A:
undetectable		 2xadA-2o08A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2o08 BH1327 PROTEIN
(Bacillus
halodurans) 		4 / 8 HIS A 109
ASP A 127
HIS A  83
ASP A  51
 FE  A 401 (-3.4A)
FE  A 400 ( 2.7A)
FE  A 401 ( 3.4A)
FE  A 401 (-2.6A)
 1.00A 2xadB-2o08A:
undetectable		 2xadB-2o08A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2o08 BH1327 PROTEIN
(Bacillus
halodurans) 		4 / 8 HIS A 109
ASP A 127
HIS A  83
ASP A  51
 FE  A 401 (-3.4A)
FE  A 400 ( 2.7A)
FE  A 401 ( 3.4A)
FE  A 401 (-2.6A)
 0.99A 2xadC-2o08A:
undetectable		 2xadC-2o08A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2o08 BH1327 PROTEIN
(Bacillus
halodurans) 		4 / 8 HIS A 109
ASP A 127
HIS A  83
ASP A  51
 FE  A 401 (-3.4A)
FE  A 400 ( 2.7A)
FE  A 401 ( 3.4A)
FE  A 401 (-2.6A)
 1.01A 2xadD-2o08A:
undetectable		 2xadD-2o08A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 2o08 BH1327 PROTEIN
(Bacillus
halodurans) 		5 / 12 LEU A  32
ALA A  43
LEU A 119
LEU A 118
ILE A 153
 PG4  A 503 (-4.7A)
None
None
None
None
 1.09A 3q95A-2o08A:
undetectable		 3q95A-2o08A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2o08 BH1327 PROTEIN
(Bacillus
halodurans) 		5 / 11 PRO A 131
ARG A 133
ILE A 129
VAL A 138
PHE A 135
 None
PO4  A 500 (-3.1A)
None
None
None
 1.34A 3rf4A-2o08A:
undetectable
3rf4C-2o08A:
undetectable		 3rf4A-2o08A:
24.23
3rf4C-2o08A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2o08 BH1327 PROTEIN
(Bacillus
halodurans) 		5 / 11 PRO A 131
ARG A 133
ILE A 129
VAL A 138
PHE A 135
 None
PO4  A 500 (-3.1A)
None
None
None
 1.32A 3rf4A-2o08A:
undetectable
3rf4B-2o08A:
undetectable		 3rf4A-2o08A:
24.23
3rf4B-2o08A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2o08 BH1327 PROTEIN
(Bacillus
halodurans) 		4 / 8 HIS A 109
GLU A 120
MET A 116
ILE A 122
 FE  A 401 (-3.4A)
None
None
None
 1.33A 4cx7A-2o08A:
undetectable
4cx7B-2o08A:
undetectable		 4cx7A-2o08A:
18.08
4cx7B-2o08A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2o08 BH1327 PROTEIN
(Bacillus
halodurans) 		4 / 6 PHE A 135
ASP A 127
TYR A 128
HIS A  21
 None
FE  A 400 ( 2.7A)
None
FE  A 400 ( 3.3A)
 1.23A 4paeA-2o08A:
undetectable		 4paeA-2o08A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 2o08 BH1327 PROTEIN
(Bacillus
halodurans) 		5 / 6 HIS A  50
HIS A  21
HIS A  83
HIS A 109
ASP A 127
 FE  A 400 (-3.3A)
FE  A 400 ( 3.3A)
FE  A 401 ( 3.4A)
FE  A 401 (-3.4A)
FE  A 400 ( 2.7A)
 1.06A 4ubpC-2o08A:
undetectable		 4ubpC-2o08A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2o08 BH1327 PROTEIN
(Bacillus
halodurans) 		5 / 8 TYR A 128
LEU A 125
GLY A 112
THR A 178
LEU A 157
 None
 1.37A 5eseA-2o08A:
undetectable		 5eseA-2o08A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 2o08 BH1327 PROTEIN
(Bacillus
halodurans) 		4 / 6 ILE A  48
ALA A  46
LEU A  45
ILE A  97
 None
 0.87A 5mvmB-2o08A:
undetectable
5mvmC-2o08A:
undetectable		 5mvmB-2o08A:
18.78
5mvmC-2o08A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2o08 BH1327 PROTEIN
(Bacillus
halodurans) 		4 / 6 ASP A  51
HIS A 109
HIS A  83
HIS A  21
 FE  A 401 (-2.6A)
FE  A 401 (-3.4A)
FE  A 401 ( 3.4A)
FE  A 400 ( 3.3A)
 0.95A 5ncdA-2o08A:
undetectable
5ncdD-2o08A:
undetectable		 5ncdA-2o08A:
21.98
5ncdD-2o08A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2o08 BH1327 PROTEIN
(Bacillus
halodurans) 		4 / 8 ASP A  51
HIS A 109
HIS A  83
HIS A  21
 FE  A 401 (-2.6A)
FE  A 401 (-3.4A)
FE  A 401 ( 3.4A)
FE  A 400 ( 3.3A)
 1.01A 5nekB-2o08A:
undetectable		 5nekB-2o08A:
16.49