SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o0a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 384
MET A 382
VAL A 381
HIS A 453
THR A 451
 None
None
None
EDO  A 700 (-3.8A)
None
 1.45A 1z95A-2o0aA:
undetectable		 1z95A-2o0aA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 461
ARG A 457
LEU A 460
LEU A 530
 None
 1.02A 2rlfA-2o0aA:
undetectable
2rlfD-2o0aA:
undetectable		 2rlfA-2o0aA:
10.57
2rlfD-2o0aA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 461
PHE A 572
VAL A 635
PHE A 424
 None
 1.01A 2ygnA-2o0aA:
undetectable		 2ygnA-2o0aA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C
(Saccharomyces
cerevisiae) 		4 / 5 THR A 374
ILE A 369
GLU A 365
PHE A 614
 None
 1.25A 4ac9C-2o0aA:
2.6		 4ac9C-2o0aA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C
(Saccharomyces
cerevisiae) 		4 / 5 THR A 374
ILE A 369
GLU A 365
PHE A 614
 None
 1.26A 4acaC-2o0aA:
2.4		 4acaC-2o0aA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C
(Saccharomyces
cerevisiae) 		4 / 5 THR A 374
ILE A 369
GLU A 365
PHE A 614
 None
 1.23A 4acbC-2o0aA:
2.5		 4acbC-2o0aA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 390
VAL A 413
TYR A 408
LEU A 619
 None
 0.89A 4b3qA-2o0aA:
undetectable		 4b3qA-2o0aA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 386
PRO A 387
LEU A 390
ILE A 399
 None
 0.96A 4f4dB-2o0aA:
undetectable		 4f4dB-2o0aA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 570
VAL A 552
ALA A 465
LEU A 437
LEU A 460
 None
 1.12A 4i1rA-2o0aA:
undetectable		 4i1rA-2o0aA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 376
GLU A 370
ASN A 366
 None
 0.87A 4imaD-2o0aA:
undetectable		 4imaD-2o0aA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 376
GLU A 370
ASN A 366
 None
 0.91A 4ip7D-2o0aA:
undetectable		 4ip7D-2o0aA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_1
(ANDROGEN RECEPTOR)		 2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 384
MET A 382
VAL A 381
HIS A 453
THR A 451
 None
None
None
EDO  A 700 (-3.8A)
None
 1.44A 4ojbA-2o0aA:
undetectable		 4ojbA-2o0aA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 384
MET A 382
VAL A 381
HIS A 453
THR A 451
 None
None
None
EDO  A 700 (-3.8A)
None
 1.46A 4okxA-2o0aA:
undetectable		 4okxA-2o0aA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 390
VAL A 413
TYR A 408
LEU A 619
 None
 0.99A 4pwdA-2o0aA:
undetectable		 4pwdA-2o0aA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 390
VAL A 413
TYR A 408
LEU A 619
 None
 0.94A 4q0bA-2o0aA:
undetectable		 4q0bA-2o0aA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 410
PHE A 443
SER A 632
VAL A 635
 None
 1.20A 5hesA-2o0aA:
undetectable		 5hesA-2o0aA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 389
PHE A 392
VAL A 625
SER A 622
 None
 1.00A 6huoC-2o0aA:
undetectable
6huoD-2o0aA:
undetectable		 6huoC-2o0aA:
15.11
6huoD-2o0aA:
12.75