SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		5 / 12 LEU A 124
VAL A 123
SER A 117
SER A 242
VAL A 130
 None
None
None
PO4  A 401 ( 4.0A)
None
 1.37A 1rk3A-2o0mA:
undetectable		 1rk3A-2o0mA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		4 / 8 LEU A 329
ALA A 336
ILE A 339
GLY A 308
 None
 0.82A 1sv9A-2o0mA:
undetectable		 1sv9A-2o0mA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		5 / 12 GLY A 151
ILE A 180
ALA A 176
ARG A 177
ILE A 306
 PO4  A 401 (-3.6A)
None
None
None
None
 1.18A 1ve3A-2o0mA:
undetectable		 1ve3A-2o0mA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		4 / 8 TYR A 275
PHE A 277
ARG A 253
LEU A 297
 None
 0.83A 1x8vA-2o0mA:
undetectable		 1x8vA-2o0mA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		4 / 8 TYR A 275
PHE A 277
HIS A 241
LEU A 297
 None
 1.14A 1x8vA-2o0mA:
undetectable		 1x8vA-2o0mA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		5 / 9 GLU A 143
ASN A 144
ILE A 146
ALA A 147
VAL A 148
 None
 1.28A 2drdA-2o0mA:
undetectable		 2drdA-2o0mA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		4 / 7 ALA A 334
GLY A 115
ASP A 332
VAL A 123
 None
 0.85A 2uyqA-2o0mA:
3.2		 2uyqA-2o0mA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		5 / 12 LEU A 124
VAL A 123
SER A 117
SER A 242
VAL A 130
 None
None
None
PO4  A 401 ( 4.0A)
None
 1.40A 2zlcA-2o0mA:
undetectable		 2zlcA-2o0mA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		5 / 12 GLY A 308
ALA A 315
VAL A 113
VAL A 123
PHE A 127
 None
 1.12A 2zulA-2o0mA:
undetectable		 2zulA-2o0mA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		5 / 12 GLY A 308
ALA A 315
VAL A 113
VAL A 123
PHE A 127
 None
 1.08A 3dmfA-2o0mA:
2.7		 3dmfA-2o0mA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		5 / 12 GLY A 308
ALA A 315
VAL A 113
VAL A 123
PHE A 127
 None
 1.09A 3dmhA-2o0mA:
undetectable		 3dmhA-2o0mA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		5 / 12 VAL A 113
ALA A 335
ALA A 336
ALA A 313
VAL A 130
 None
 1.00A 3fc6C-2o0mA:
undetectable		 3fc6C-2o0mA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		3 / 3 ASN A 197
ASN A 202
GLU A 165
 None
 0.74A 3kpdC-2o0mA:
undetectable		 3kpdC-2o0mA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		3 / 3 ASN A 197
ASN A 202
GLU A 165
 None
 0.86A 3kpdB-2o0mA:
undetectable		 3kpdB-2o0mA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		5 / 12 HIS A 170
MET A 195
GLY A 201
ALA A 158
LEU A 131
 None
 1.32A 3tm4A-2o0mA:
2.0		 3tm4A-2o0mA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		5 / 12 HIS A 170
MET A 195
GLY A 201
ALA A 158
LEU A 131
 None
 1.31A 3tm4B-2o0mA:
undetectable		 3tm4B-2o0mA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		4 / 8 THR A 134
ILE A 111
VAL A 113
GLY A 128
 None
 0.88A 4eq4B-2o0mA:
undetectable		 4eq4B-2o0mA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		4 / 8 ASP A 332
ALA A 307
SER A 117
ASP A 118
 None
 0.97A 4k0bB-2o0mA:
undetectable		 4k0bB-2o0mA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		4 / 8 ASP A 332
ALA A 307
SER A 117
ASP A 118
 None
 0.97A 4l7iB-2o0mA:
undetectable		 4l7iB-2o0mA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		6 / 11 ALA A 315
ALA A 270
GLY A 309
GLY A 308
ALA A 307
SER A 242
 None
None
None
None
None
PO4  A 401 ( 4.0A)
 1.50A 4qvlK-2o0mA:
undetectable
4qvlL-2o0mA:
undetectable		 4qvlK-2o0mA:
19.48
4qvlL-2o0mA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		5 / 12 ILE A 290
GLY A 178
PRO A 175
VAL A 208
ILE A 226
 None
 0.98A 4rvdA-2o0mA:
2.6		 4rvdA-2o0mA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		5 / 12 ILE A 290
GLY A 178
PRO A 175
VAL A 208
ILE A 226
 None
 0.98A 4rvgA-2o0mA:
2.3		 4rvgA-2o0mA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		6 / 11 ALA A 315
ALA A 270
GLY A 309
GLY A 308
ALA A 307
SER A 242
 None
None
None
None
None
PO4  A 401 ( 4.0A)
 1.49A 5bxnK-2o0mA:
undetectable
5bxnL-2o0mA:
undetectable		 5bxnK-2o0mA:
19.48
5bxnL-2o0mA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY
(Enterococcus
faecalis) 		5 / 12 PHE A 277
GLY A 244
LEU A 329
MET A 320
LEU A 294
 None
PO4  A 401 ( 4.2A)
None
None
None
 1.48A 5ji0D-2o0mA:
undetectable		 5ji0D-2o0mA:
20.90