SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o0o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2o0o TNF SUPERFAMILY
LIGAND TL1A
(Homo
sapiens) 		4 / 7 LEU A 226
ILE A 181
PHE A 218
ALA A 248
 None
 0.84A 1oniB-2o0oA:
undetectable
1oniC-2o0oA:
undetectable		 1oniB-2o0oA:
19.89
1oniC-2o0oA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 2o0o TNF SUPERFAMILY
LIGAND TL1A
(Homo
sapiens) 		5 / 12 THR A 182
GLY A 197
ILE A 177
LEU A 195
VAL A 153
 None
 1.21A 3fzgA-2o0oA:
undetectable		 3fzgA-2o0oA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2o0o TNF SUPERFAMILY
LIGAND TL1A
(Homo
sapiens) 		5 / 12 LEU A 195
GLY A 197
ILE A 212
ILE A 149
ILE A 181
 None
 0.96A 6emuA-2o0oA:
undetectable		 6emuA-2o0oA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2o0o TNF SUPERFAMILY
LIGAND TL1A
(Homo
sapiens) 		5 / 12 LEU A 195
GLY A 197
ILE A 212
ILE A 149
ILE A 181
 None
 1.00A 6emuB-2o0oA:
undetectable		 6emuB-2o0oA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2o0o TNF SUPERFAMILY
LIGAND TL1A
(Homo
sapiens) 		5 / 12 LEU A 195
GLY A 197
ILE A 212
ILE A 149
ILE A 181
 None
 0.98A 6emuC-2o0oA:
undetectable		 6emuC-2o0oA:
20.40