SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o0r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		4 / 7 THR A 373
TYR A 316
TYR A 201
LEU A 204
 None
LLP  A 232 ( 4.6A)
LLP  A 232 ( 4.3A)
None
 1.08A 1qzrA-2o0rA:
undetectable		 1qzrA-2o0rA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		4 / 7 THR A 373
TYR A 316
TYR A 201
LEU A 204
 None
LLP  A 232 ( 4.6A)
LLP  A 232 ( 4.3A)
None
 1.04A 1qzrB-2o0rA:
undetectable		 1qzrB-2o0rA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  53
GLN A  56
ILE A  50
PRO A 268
 None
 0.94A 1rxcB-2o0rA:
undetectable		 1rxcB-2o0rA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  53
GLN A  56
ILE A  50
PRO A 268
 None
 0.94A 1rxcE-2o0rA:
undetectable		 1rxcE-2o0rA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		4 / 7 GLY A  53
GLN A  56
ILE A  50
PRO A 268
 None
 0.94A 1rxcF-2o0rA:
undetectable		 1rxcF-2o0rA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 353
PHE A 118
ARG A 133
 None
 0.85A 2a3aA-2o0rA:
undetectable		 2a3aA-2o0rA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		3 / 3 PHE A 145
VAL A 365
TRP A 366
 None
 0.91A 2cc8A-2o0rA:
undetectable		 2cc8A-2o0rA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 125
ILE A 164
ILE A 196
ILE A 227
ALA A 244
 None
 0.97A 2gj5A-2o0rA:
undetectable		 2gj5A-2o0rA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 176
SER A 177
ILE A 184
GLU A 180
ASP A 148
 None
CL  A 601 ( 4.1A)
None
None
None
 1.32A 3ko0A-2o0rA:
undetectable
3ko0B-2o0rA:
0.0
3ko0C-2o0rA:
undetectable
3ko0D-2o0rA:
undetectable		 3ko0A-2o0rA:
13.37
3ko0B-2o0rA:
13.37
3ko0C-2o0rA:
13.37
3ko0D-2o0rA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		5 / 11 GLU A 180
ASP A 148
LEU A 176
SER A 177
ILE A 184
 None
None
None
CL  A 601 ( 4.1A)
None
 1.41A 3ko0C-2o0rA:
undetectable
3ko0D-2o0rA:
undetectable
3ko0E-2o0rA:
0.0
3ko0F-2o0rA:
undetectable		 3ko0C-2o0rA:
13.37
3ko0D-2o0rA:
13.37
3ko0E-2o0rA:
13.37
3ko0F-2o0rA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		5 / 11 GLU A 180
ASP A 148
LEU A 176
SER A 177
ILE A 184
 None
None
None
CL  A 601 ( 4.1A)
None
 1.24A 3ko0E-2o0rA:
0.0
3ko0F-2o0rA:
undetectable
3ko0G-2o0rA:
0.0
3ko0H-2o0rA:
undetectable		 3ko0E-2o0rA:
13.37
3ko0F-2o0rA:
13.37
3ko0G-2o0rA:
13.37
3ko0H-2o0rA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ202_1
(PROTEIN S100-A4)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 176
SER A 177
ILE A 184
GLU A 180
ASP A 148
 None
CL  A 601 ( 4.1A)
None
None
None
 1.35A 3ko0O-2o0rA:
undetectable
3ko0P-2o0rA:
undetectable
3ko0Q-2o0rA:
0.0
3ko0R-2o0rA:
0.0		 3ko0O-2o0rA:
13.37
3ko0P-2o0rA:
13.37
3ko0Q-2o0rA:
13.37
3ko0R-2o0rA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		4 / 7 GLN A  73
HIS A  77
GLU A 202
PRO A 168
 None
 1.15A 3ql6A-2o0rA:
undetectable		 3ql6A-2o0rA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_2
(NEURAMINIDASE)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 150
ARG A 153
ARG A 154
ILE A 187
 None
 1.35A 3sanA-2o0rA:
undetectable		 3sanA-2o0rA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_2
(NEURAMINIDASE)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 150
ARG A 153
ARG A 154
ILE A 187
 None
 1.37A 3sanB-2o0rA:
undetectable		 3sanB-2o0rA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		4 / 5 PHE A 333
PHE A 372
ALA A 320
LEU A 325
 None
 1.23A 3t3zC-2o0rA:
undetectable		 3t3zC-2o0rA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		5 / 8 GLY A  60
GLY A  62
GLY A 265
ILE A 241
VAL A  92
 None
 1.18A 3v1nA-2o0rA:
2.4		 3v1nA-2o0rA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  53
GLN A  56
ILE A  50
PRO A 268
 None
 0.97A 4e1vA-2o0rA:
undetectable		 4e1vA-2o0rA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		4 / 7 GLY A  53
GLN A  56
ILE A  50
PRO A 268
 None
 0.96A 4e1vB-2o0rA:
undetectable		 4e1vB-2o0rA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  53
GLN A  56
ILE A  50
PRO A 268
 None
 0.96A 4e1vC-2o0rA:
undetectable		 4e1vC-2o0rA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  53
GLN A  56
ILE A  50
PRO A 268
 None
 0.95A 4e1vG-2o0rA:
undetectable		 4e1vG-2o0rA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 298
LEU A 318
SER A 312
THR A 315
 None
 1.12A 4iklA-2o0rA:
undetectable
4iklB-2o0rA:
undetectable		 4iklA-2o0rA:
14.57
4iklB-2o0rA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_A_LYAA304_1
(FOLATE RECEPTOR BETA)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 198
SER A 262
GLY A 238
SER A 121
TYR A 122
 LLP  A 232 ( 2.8A)
None
None
None
None
 1.36A 4kn2A-2o0rA:
undetectable		 4kn2A-2o0rA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_1
(FOLATE RECEPTOR BETA)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 198
SER A 262
GLY A 238
SER A 121
TYR A 122
 LLP  A 232 ( 2.8A)
None
None
None
None
 1.40A 4kn2C-2o0rA:
0.0		 4kn2C-2o0rA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 379
LYS A 376
LEU A  29
 None
 0.96A 4ptjA-2o0rA:
undetectable		 4ptjA-2o0rA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		6 / 12 LEU A 250
ALA A 244
ILE A 196
ILE A  98
VAL A 194
ILE A 225
 None
 1.46A 4q1xB-2o0rA:
undetectable		 4q1xB-2o0rA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 171
PHE A 145
PHE A 351
TRP A 366
 None
 1.28A 4v2zC-2o0rA:
undetectable		 4v2zC-2o0rA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 278
ARG A  68
PRO A  65
 None
 1.08A 4wanC-2o0rA:
undetectable		 4wanC-2o0rA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 320
LEU A 381
LEU A 318
LEU A 298
ARG A 297
 None
 1.30A 4x30A-2o0rA:
undetectable		 4x30A-2o0rA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 346
ALA A 344
MET A  17
ALA A  19
ASN A  28
 None
 1.48A 4zo1X-2o0rA:
undetectable		 4zo1X-2o0rA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 194
LEU A  89
LEU A 261
ALA A 101
LEU A 105
 None
 1.35A 5iktB-2o0rA:
undetectable		 5iktB-2o0rA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 314
ASP A 207
PHE A 206
PHE A 374
 None
 0.96A 5mvsB-2o0rA:
3.9		 5mvsB-2o0rA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 134
GLU A 111
LEU A 147
ALA A 155
LEU A 193
 None
 1.25A 5nd2B-2o0rA:
undetectable		 5nd2B-2o0rA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		4 / 8 ARG A  67
SER A  63
ALA A 274
ALA A  71
 None
 0.82A 5te8B-2o0rA:
undetectable		 5te8B-2o0rA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 374
ALA A 209
ARG A 288
GLY A 314
GLY A 173
 None
 1.16A 5ul4A-2o0rA:
2.7		 5ul4A-2o0rA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		4 / 6 ARG A  67
SER A  63
ALA A 274
ALA A  71
 None
 0.96A 6ma6A-2o0rA:
undetectable		 6ma6A-2o0rA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		4 / 7 ARG A  67
SER A  63
ALA A 274
ALA A  71
 None
 0.93A 6ma7A-2o0rA:
undetectable		 6ma7A-2o0rA:
11.03