SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o0x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 187
VAL A 224
TRP A 222
 None
 0.85A 1av2C-2o0xA:
undetectable
1av2D-2o0xA:
undetectable		 1av2C-2o0xA:
3.19
1av2D-2o0xA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 12 TRP A 419
PHE A 415
GLY A 390
ALA A 389
LEU A 319
 None
 1.02A 1fe2A-2o0xA:
undetectable		 1fe2A-2o0xA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 132
LEU A 185
ARG A 221
PHE A 170
ILE A 162
 None
 1.15A 1g5yC-2o0xA:
undetectable		 1g5yC-2o0xA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 385
THR A 411
GLU A 311
SER A  52
ILE A 236
 SKP  A 501 (-3.8A)
None
SKP  A 501 (-4.0A)
None
None
 1.36A 1odiA-2o0xA:
undetectable		 1odiA-2o0xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 385
THR A 411
GLY A  21
GLU A 311
ILE A 236
 SKP  A 501 (-3.8A)
None
None
SKP  A 501 (-4.0A)
None
 1.40A 1odiA-2o0xA:
undetectable		 1odiA-2o0xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 385
THR A 411
GLU A 311
SER A  52
ILE A 236
 SKP  A 501 (-3.8A)
None
SKP  A 501 (-4.0A)
None
None
 1.33A 1odiB-2o0xA:
undetectable		 1odiB-2o0xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 385
THR A 411
GLY A  21
GLU A 311
ILE A 236
 SKP  A 501 (-3.8A)
None
None
SKP  A 501 (-4.0A)
None
 1.41A 1odiB-2o0xA:
undetectable		 1odiB-2o0xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 385
THR A 411
GLY A  21
GLU A 311
ILE A 236
 SKP  A 501 (-3.8A)
None
None
SKP  A 501 (-4.0A)
None
 1.43A 1odiC-2o0xA:
undetectable		 1odiC-2o0xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 385
THR A 411
GLU A 311
SER A  52
ILE A 236
 SKP  A 501 (-3.8A)
None
SKP  A 501 (-4.0A)
None
None
 1.32A 1odiD-2o0xA:
undetectable		 1odiD-2o0xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 385
THR A 411
GLY A  21
GLU A 311
ILE A 236
 SKP  A 501 (-3.8A)
None
None
SKP  A 501 (-4.0A)
None
 1.39A 1odiD-2o0xA:
undetectable		 1odiD-2o0xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 385
THR A 411
GLU A 311
SER A  52
ILE A 236
 SKP  A 501 (-3.8A)
None
SKP  A 501 (-4.0A)
None
None
 1.32A 1odiE-2o0xA:
undetectable		 1odiE-2o0xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 385
THR A 411
GLY A  21
GLU A 311
ILE A 236
 SKP  A 501 (-3.8A)
None
None
SKP  A 501 (-4.0A)
None
 1.39A 1odiE-2o0xA:
undetectable		 1odiE-2o0xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 385
THR A 411
GLU A 311
SER A  52
ILE A 236
 SKP  A 501 (-3.8A)
None
SKP  A 501 (-4.0A)
None
None
 1.33A 1odiF-2o0xA:
undetectable		 1odiF-2o0xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 385
THR A 411
GLY A  21
GLU A 311
ILE A 236
 SKP  A 501 (-3.8A)
None
None
SKP  A 501 (-4.0A)
None
 1.37A 1odiF-2o0xA:
undetectable		 1odiF-2o0xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		3 / 3 TRP A   4
PHE A 415
TRP A 419
 None
 1.24A 1r15C-2o0xA:
undetectable		 1r15C-2o0xA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		3 / 3 TRP A   4
PHE A 415
TRP A 419
 None
 1.24A 1r15F-2o0xA:
undetectable		 1r15F-2o0xA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		3 / 3 TRP A   4
PHE A 415
TRP A 419
 None
 1.24A 1r15G-2o0xA:
undetectable		 1r15G-2o0xA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		3 / 3 TRP A   4
PHE A 415
TRP A 419
 None
 1.25A 1r15H-2o0xA:
undetectable		 1r15H-2o0xA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 8 ALA A 380
ASP A 383
ILE A 405
GLY A 390
ILE A 393
 None
 1.41A 1sh9A-2o0xA:
undetectable		 1sh9A-2o0xA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 8 ASP A 403
ALA A 380
ILE A 405
GLY A 390
PRO A   5
 None
 1.38A 1sh9A-2o0xA:
undetectable		 1sh9A-2o0xA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 187
VAL A 224
TRP A 222
 None
 0.92A 1w5uC-2o0xA:
undetectable
1w5uD-2o0xA:
undetectable		 1w5uC-2o0xA:
3.19
1w5uD-2o0xA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 280
LEU A 277
LEU A 274
ALA A 275
LEU A 306
 None
 1.16A 1ya3C-2o0xA:
undetectable		 1ya3C-2o0xA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 100
LEU A 129
LEU A 185
VAL A 187
 SKP  A 501 ( 4.7A)
None
None
None
 1.02A 2bdmA-2o0xA:
undetectable		 2bdmA-2o0xA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 224
TRP A 222
VAL A 187
 None
 0.83A 2izqA-2o0xA:
undetectable
2izqB-2o0xA:
undetectable		 2izqA-2o0xA:
3.19
2izqB-2o0xA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  49
LEU A  62
LEU A  59
LEU A  76
LEU A  30
 None
 1.13A 2riwA-2o0xA:
undetectable
2riwB-2o0xA:
undetectable		 2riwA-2o0xA:
21.56
2riwB-2o0xA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 352
LEU A 355
VAL A 400
GLY A 394
GLY A 390
 None
 1.25A 2wd9C-2o0xA:
undetectable		 2wd9C-2o0xA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 247
ALA A 275
LEU A 274
ILE A 392
 None
 0.85A 3cldB-2o0xA:
undetectable		 3cldB-2o0xA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 358
VAL A 367
THR A 369
VAL A 328
 None
 0.53A 3em0B-2o0xA:
undetectable		 3em0B-2o0xA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 187
VAL A 224
TRP A 222
 None
 0.68A 3l8lA-2o0xA:
undetectable
3l8lB-2o0xA:
undetectable		 3l8lA-2o0xA:
3.19
3l8lB-2o0xA:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  57
SER A  24
ASN A  27
THR A 241
 None
SKP  A 501 (-2.6A)
None
None
 0.93A 3lm8B-2o0xA:
undetectable
3lm8D-2o0xA:
undetectable		 3lm8B-2o0xA:
17.53
3lm8D-2o0xA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 8 ALA A  95
GLY A  96
THR A  97
GLN A 169
 None
SKP  A 501 (-3.8A)
SKP  A 501 (-3.8A)
SKP  A 501 (-3.6A)
 0.84A 3rglA-2o0xA:
undetectable		 3rglA-2o0xA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 10 ARG A 385
THR A 411
GLY A  21
GLU A 311
ILE A 236
 SKP  A 501 (-3.8A)
None
None
SKP  A 501 (-4.0A)
None
 1.35A 3uayA-2o0xA:
undetectable		 3uayA-2o0xA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 276
ALA A 282
LEU A 277
LEU A 291
HIS A 286
 None
None
None
None
SO4  A 503 (-4.0A)
 1.09A 3uvvA-2o0xA:
undetectable		 3uvvA-2o0xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 12 SER A 315
VAL A 252
ILE A 273
LEU A 277
VAL A 251
 None
 0.95A 3w68B-2o0xA:
undetectable		 3w68B-2o0xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 5 PHE A 415
LEU A 395
GLY A 394
ILE A 405
VAL A 402
 None
 1.33A 3wrkA-2o0xA:
undetectable		 3wrkA-2o0xA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 415
LEU A 395
GLY A 390
ILE A 405
ALA A 318
 None
 1.14A 4a6dA-2o0xA:
undetectable		 4a6dA-2o0xA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 415
LEU A 395
GLY A 390
ILE A 405
ALA A 318
 None
 1.09A 4a6eA-2o0xA:
undetectable		 4a6eA-2o0xA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 380
ASP A 383
ILE A 392
THR A   3
 None
 0.96A 4eyrA-2o0xA:
undetectable		 4eyrA-2o0xA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 244
LEU A 306
ILE A 276
ALA A 318
 None
 0.79A 4zf8A-2o0xA:
undetectable		 4zf8A-2o0xA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 245
ALA A 243
VAL A  19
VAL A  17
TRP A 419
 None
 1.37A 5eb5B-2o0xA:
undetectable		 5eb5B-2o0xA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 5 PHE A 415
LEU A 395
GLY A 394
ILE A 405
 None
 1.02A 5ik1A-2o0xA:
undetectable		 5ik1A-2o0xA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 212
PRO A 103
PHE A 101
PHE A 181
 None
None
SKP  A 501 (-4.9A)
None
 0.97A 6aycA-2o0xA:
undetectable		 6aycA-2o0xA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  13
LEU A 291
LEU A 247
ALA A 250
SER A 253
 None
 1.00A 6b0iB-2o0xA:
undetectable		 6b0iB-2o0xA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 12 MET A 386
ALA A 346
VAL A 397
LEU A 366
ALA A 317
 None
 1.15A 6djzC-2o0xA:
undetectable		 6djzC-2o0xA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 100
PHE A 101
GLY A  96
 SKP  A 501 ( 4.7A)
SKP  A 501 (-4.9A)
SKP  A 501 (-3.8A)
 0.64A 6fgdA-2o0xA:
undetectable		 6fgdA-2o0xA:
24.29