SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o0y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2o0y TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
sp.) 		5 / 11 SER A 172
PHE A 178
LEU A 182
VAL A 186
VAL A 168
 None
 1.35A 1q23J-2o0yA:
undetectable		 1q23J-2o0yA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 2o0y TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
sp.) 		5 / 9 ALA A 153
SER A 206
PHE A 232
GLY A 227
SER A 209
 None
 1.40A 2vh3A-2o0yA:
undetectable		 2vh3A-2o0yA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2o0y TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
sp.) 		4 / 4 ASN A 115
SER A 252
LEU A 212
THR A 113
 None
 1.47A 4an2A-2o0yA:
undetectable		 4an2A-2o0yA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2o0y TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
sp.) 		4 / 8 ALA A 246
GLU A 250
ASP A 101
ASP A 109
 None
 0.90A 4kttD-2o0yA:
undetectable		 4kttD-2o0yA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2o0y TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
sp.) 		5 / 8 ALA A 247
ALA A 248
ILE A 251
ALA A 153
LEU A 116
 None
 1.47A 4v1fA-2o0yA:
undetectable
4v1fB-2o0yA:
undetectable		 4v1fA-2o0yA:
14.62
4v1fB-2o0yA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 2o0y TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
sp.) 		4 / 5 ARG A 245
ARG A 190
GLY A 189
GLU A 187
 None
 1.16A 4z3oA-2o0yA:
4.5
4z3oB-2o0yA:
4.5		 4z3oA-2o0yA:
15.53
4z3oB-2o0yA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 2o0y TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
sp.) 		5 / 12 VAL A 126
ALA A 128
THR A 244
SER A 107
ASN A 115
 None
 1.29A 5hgcA-2o0yA:
undetectable		 5hgcA-2o0yA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 2o0y TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
sp.) 		4 / 7 LEU A 148
LEU A 158
ALA A 160
ALA A 161
 None
 0.69A 6a7jA-2o0yA:
undetectable		 6a7jA-2o0yA:
14.45