SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o14'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		4 / 8 ALA A 270
ILE A 262
ILE A 224
ILE A 228
 None
 0.67A 1hshD-2o14A:
undetectable		 1hshD-2o14A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		5 / 9 PHE A 123
VAL A  91
LEU A 150
MET A 114
LEU A 134
 None
 1.16A 1wrkA-2o14A:
undetectable
1wrkB-2o14A:
undetectable		 1wrkA-2o14A:
12.00
1wrkB-2o14A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		4 / 6 PHE A 123
VAL A  91
LEU A 150
MET A 114
 None
 1.05A 1wrlB-2o14A:
undetectable		 1wrlB-2o14A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		4 / 6 ALA A  57
SER A  58
ASN A  97
ASP A 117
 None
 0.96A 1yc2A-2o14A:
undetectable		 1yc2A-2o14A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		6 / 12 GLY A 231
ASP A 271
ILE A 364
GLY A 366
VAL A 202
ILE A 165
 None
 1.49A 2bpxB-2o14A:
undetectable		 2bpxB-2o14A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		3 / 3 ALA A 185
VAL A 173
TRP A 187
 None
 0.98A 2izqA-2o14A:
undetectable
2izqB-2o14A:
undetectable		 2izqA-2o14A:
4.14
2izqB-2o14A:
4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		6 / 12 GLY A 231
ASP A 271
ILE A 364
GLY A 366
VAL A 202
ILE A 165
 None
 1.49A 2o4lB-2o14A:
undetectable		 2o4lB-2o14A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		3 / 3 LEU A 179
TYR A 177
GLY A 116
 None
 0.57A 2ocuA-2o14A:
undetectable		 2ocuA-2o14A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		4 / 7 TYR A 176
TYR A 177
PRO A 178
THR A 115
 None
 1.24A 2q6kA-2o14A:
3.2		 2q6kA-2o14A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		3 / 3 TRP A 187
ALA A 185
VAL A 173
 None
 1.01A 3l8lA-2o14A:
undetectable
3l8lB-2o14A:
undetectable		 3l8lA-2o14A:
4.14
3l8lB-2o14A:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		3 / 3 ARG A 345
ASP A 121
GLN A 201
 None
 0.60A 3lcvB-2o14A:
undetectable		 3lcvB-2o14A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		5 / 11 SER A 148
THR A  94
ALA A  60
GLY A  59
ALA A  57
 None
 1.06A 3mg0H-2o14A:
undetectable
3mg0I-2o14A:
undetectable		 3mg0H-2o14A:
22.52
3mg0I-2o14A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		5 / 11 VAL A 167
GLY A 169
ALA A 185
TYR A 176
ASN A 204
 None
 1.23A 3qxyB-2o14A:
undetectable
3qxyQ-2o14A:
undetectable		 3qxyB-2o14A:
21.55
3qxyQ-2o14A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		4 / 8 GLY A 269
ALA A 270
ASP A 271
THR A 161
 None
 0.83A 4eyrB-2o14A:
undetectable		 4eyrB-2o14A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		5 / 11 SER A 148
THR A  94
ALA A  60
GLY A  59
ALA A  57
 None
 1.08A 4qvvH-2o14A:
undetectable		 4qvvH-2o14A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		5 / 11 SER A 148
THR A  94
ALA A  60
GLY A  59
ALA A  57
 None
 1.07A 4qvvV-2o14A:
undetectable		 4qvvV-2o14A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		5 / 11 SER A 148
THR A  94
ALA A  60
GLY A  59
ALA A  57
 None
 1.10A 4qvyH-2o14A:
undetectable		 4qvyH-2o14A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		5 / 11 SER A 148
THR A  94
ALA A  60
GLY A  59
ALA A  57
 None
 1.08A 5d0xV-2o14A:
undetectable		 5d0xV-2o14A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		4 / 8 VAL A  82
GLU A 106
GLY A 130
GLY A  87
 None
 0.90A 5e26C-2o14A:
undetectable
5e26D-2o14A:
undetectable		 5e26C-2o14A:
23.75
5e26D-2o14A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		4 / 6 GLY A 209
SER A 207
GLY A 169
ASN A 241
 None
 0.92A 5k4pA-2o14A:
undetectable		 5k4pA-2o14A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		5 / 12 SER A 148
THR A  94
ALA A  60
GLY A  59
ALA A  57
 None
 1.05A 5l5zH-2o14A:
undetectable
5l5zI-2o14A:
undetectable		 5l5zH-2o14A:
22.16
5l5zI-2o14A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		5 / 12 SER A 148
THR A  94
ALA A  60
GLY A  59
ALA A  57
 None
 1.05A 5l5zV-2o14A:
undetectable
5l5zW-2o14A:
undetectable		 5l5zV-2o14A:
22.16
5l5zW-2o14A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		4 / 5 ASP A  83
ILE A  30
ASN A  77
TYR A  38
 None
 1.24A 6a93B-2o14A:
undetectable		 6a93B-2o14A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		3 / 3 TYR A 176
HIS A 342
MET A 336
 None
 1.19A 6af6A-2o14A:
undetectable		 6af6A-2o14A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		3 / 3 PHE A 234
ASP A 271
LYS A 266
 None
 0.88A 6awtD-2o14A:
undetectable		 6awtD-2o14A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		5 / 9 ASN A 241
LEU A 238
GLY A 208
THR A 172
VAL A 173
 None
 1.17A 6czmB-2o14A:
undetectable
6czmC-2o14A:
undetectable		 6czmB-2o14A:
21.09
6czmC-2o14A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		5 / 9 ASN A 241
LEU A 238
GLY A 208
THR A 172
VAL A 173
 None
 1.19A 6czmD-2o14A:
undetectable
6czmE-2o14A:
undetectable		 6czmD-2o14A:
21.09
6czmE-2o14A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		5 / 10 ASN A 241
LEU A 238
GLY A 208
THR A 172
VAL A 173
 None
 1.18A 6czmE-2o14A:
undetectable
6czmF-2o14A:
undetectable		 6czmE-2o14A:
21.09
6czmF-2o14A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		3 / 3 GLY A 231
ASP A 271
ILE A 364
 None
 0.59A 6dgxB-2o14A:
undetectable		 6dgxB-2o14A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		4 / 6 MET A 114
GLY A 118
ALA A 149
LEU A 147
 None
 0.98A 6fosA-2o14A:
undetectable		 6fosA-2o14A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2o14 HYPOTHETICAL PROTEIN
YXIM
(Bacillus
subtilis) 		5 / 9 ASP A 121
TYR A 177
GLY A 208
ASN A 204
VAL A 173
 None
 1.44A 6giqA-2o14A:
undetectable
6giqE-2o14A:
undetectable
6giqI-2o14A:
undetectable		 6giqA-2o14A:
23.11
6giqE-2o14A:
19.46
6giqI-2o14A:
11.65