SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o16'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE
(Vibrio
cholerae) 		4 / 5 GLU A 158
LEU A 152
LEU A 155
LEU A 153
 None
 1.01A 1np1A-2o16A:
undetectable		 1np1A-2o16A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE
(Vibrio
cholerae) 		4 / 7 THR A  28
SER A 143
ASP A 144
LEU A  46
 None
PO4  A   1 (-2.8A)
None
None
 1.01A 2hdnE-2o16A:
undetectable
2hdnF-2o16A:
undetectable
2hdnH-2o16A:
undetectable		 2hdnE-2o16A:
14.93
2hdnF-2o16A:
19.40
2hdnH-2o16A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE
(Vibrio
cholerae) 		4 / 7 LEU A  46
THR A  28
SER A 143
ASP A 144
 None
None
PO4  A   1 (-2.8A)
None
 1.01A 2hdnF-2o16A:
undetectable
2hdnG-2o16A:
undetectable
2hdnH-2o16A:
undetectable		 2hdnF-2o16A:
19.40
2hdnG-2o16A:
14.93
2hdnH-2o16A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE
(Vibrio
cholerae) 		5 / 12 ILE A 139
ASP A 144
THR A  28
ILE A  52
PRO A  56
 None
None
None
PO4  A   1 (-4.4A)
None
 0.71A 3kpbA-2o16A:
16.8		 3kpbA-2o16A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE
(Vibrio
cholerae) 		5 / 12 ILE A 139
THR A 141
ASP A 144
ILE A  52
PRO A  56
 None
PO4  A   1 (-3.0A)
None
PO4  A   1 (-4.4A)
None
 0.72A 3kpbA-2o16A:
16.8		 3kpbA-2o16A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE
(Vibrio
cholerae) 		5 / 12 HIS A  54
ILE A  67
ASP A  72
ILE A 125
PRO A 129
 PO4  A   1 (-3.8A)
None
PO4  A   7 (-2.9A)
None
None
 1.26A 3kpbC-2o16A:
17.3		 3kpbC-2o16A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE
(Vibrio
cholerae) 		7 / 12 HIS A  54
ILE A 139
THR A 141
ASP A 144
THR A  28
ILE A  52
PRO A  56
 PO4  A   1 (-3.8A)
None
PO4  A   1 (-3.0A)
None
None
PO4  A   1 (-4.4A)
None
 0.90A 3kpbC-2o16A:
17.3		 3kpbC-2o16A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE
(Vibrio
cholerae) 		6 / 11 ILE A 139
THR A 141
ASP A 144
THR A  28
ILE A  52
PRO A  56
 None
PO4  A   1 (-3.0A)
None
None
PO4  A   1 (-4.4A)
None
 0.82A 3kpcA-2o16A:
18.8		 3kpcA-2o16A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE
(Vibrio
cholerae) 		6 / 12 ILE A 139
THR A 141
ASP A 144
THR A  28
ILE A  52
PRO A  56
 None
PO4  A   1 (-3.0A)
None
None
PO4  A   1 (-4.4A)
None
 0.78A 3kpdB-2o16A:
17.5		 3kpdB-2o16A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE
(Vibrio
cholerae) 		6 / 12 ILE A 139
ASP A 144
THR A  28
ILE A  52
VAL A  55
PRO A  56
 None
None
None
PO4  A   1 (-4.4A)
None
None
 0.72A 3kpdC-2o16A:
18.0		 3kpdC-2o16A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE
(Vibrio
cholerae) 		6 / 12 ILE A 139
THR A 141
ASP A 144
ILE A  52
VAL A  55
PRO A  56
 None
PO4  A   1 (-3.0A)
None
PO4  A   1 (-4.4A)
None
None
 0.63A 3kpdC-2o16A:
18.0		 3kpdC-2o16A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE
(Vibrio
cholerae) 		5 / 11 VAL A 130
ASP A 144
PHE A 145
VAL A 107
THR A  28
 None
 1.44A 4eilA-2o16A:
undetectable		 4eilA-2o16A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE
(Vibrio
cholerae) 		5 / 10 VAL A 130
ASP A 144
PHE A 145
VAL A 107
THR A  28
 None
 1.49A 4eilB-2o16A:
undetectable		 4eilB-2o16A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE
(Vibrio
cholerae) 		5 / 11 VAL A 130
ASP A 144
PHE A 145
VAL A 107
THR A  28
 None
 1.41A 4eilC-2o16A:
undetectable		 4eilC-2o16A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE
(Vibrio
cholerae) 		5 / 10 VAL A 130
ASP A 144
PHE A 145
VAL A 107
THR A  28
 None
 1.48A 4eilD-2o16A:
undetectable		 4eilD-2o16A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE
(Vibrio
cholerae) 		5 / 11 VAL A 130
ASP A 144
PHE A 145
VAL A 107
THR A  28
 None
 1.44A 4eilE-2o16A:
undetectable		 4eilE-2o16A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE
(Vibrio
cholerae) 		4 / 5 ILE A  67
ARG A  53
ASP A 142
VAL A 130
 None
PO4  A   6 ( 3.1A)
PO4  A   6 ( 2.6A)
None
 0.97A 4nkxC-2o16A:
undetectable		 4nkxC-2o16A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE
(Vibrio
cholerae) 		4 / 5 ILE A  67
ARG A  53
ASP A 142
VAL A 130
 None
PO4  A   6 ( 3.1A)
PO4  A   6 ( 2.6A)
None
 0.97A 4nkxD-2o16A:
undetectable		 4nkxD-2o16A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE
(Vibrio
cholerae) 		4 / 6 LEU A  73
VAL A  68
LEU A  96
VAL A  55
 None
 0.95A 5x7zA-2o16A:
undetectable		 5x7zA-2o16A:
22.86