SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o1b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		5 / 12 HIS A  48
ILE A 275
LEU A 270
GLY A 268
TYR A  96
 None
 1.14A 1axwA-2o1bA:
undetectable		 1axwA-2o1bA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		5 / 11 ILE A 275
LEU A 270
GLY A 268
TYR A  96
VAL A 242
 None
 1.14A 1axwB-2o1bA:
undetectable		 1axwB-2o1bA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		3 / 3 PHE A 350
TYR A 318
PRO A 173
 None
 1.02A 1mcnA-2o1bA:
undetectable
1mcnB-2o1bA:
undetectable
1mcnP-2o1bA:
undetectable		 1mcnA-2o1bA:
19.20
1mcnB-2o1bA:
19.20
1mcnP-2o1bA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		4 / 7 ALA A 274
TYR A 229
TYR A  82
TYR A  78
 None
 1.12A 2ajvH-2o1bA:
undetectable
2ajvL-2o1bA:
undetectable		 2ajvH-2o1bA:
18.81
2ajvL-2o1bA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		4 / 7 PHE A 190
THR A 162
LEU A 167
VAL A 154
 None
 0.98A 2cppA-2o1bA:
undetectable		 2cppA-2o1bA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		4 / 7 ARG A 295
GLU A 300
ALA A 372
ALA A 373
 None
 0.96A 2ejfA-2o1bA:
undetectable		 2ejfA-2o1bA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO6_A_ETVA302_1
(DEOXYCYTIDINE KINASE)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		5 / 12 ILE A 275
LEU A 231
MET A 237
ARG A  80
ASP A 282
 None
 1.45A 2no6A-2o1bA:
0.6		 2no6A-2o1bA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO6_B_ETVB302_1
(DEOXYCYTIDINE KINASE)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		5 / 11 ILE A 275
LEU A 231
MET A 237
ARG A  80
ASP A 282
 None
 1.41A 2no6B-2o1bA:
0.5		 2no6B-2o1bA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		5 / 12 MET A  32
ILE A 360
ALA A 372
VAL A 291
LEU A 362
 None
 1.31A 2rctA-2o1bA:
undetectable		 2rctA-2o1bA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		4 / 8 TYR A 166
LEU A 167
LYS A 196
ALA A 225
 None
 0.97A 2wekA-2o1bA:
4.6		 2wekA-2o1bA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		5 / 12 LEU A 255
PRO A 137
GLY A 129
GLY A 101
LEU A  95
 None
 1.04A 3e23A-2o1bA:
3.9		 3e23A-2o1bA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		5 / 9 ALA A 273
LEU A 231
VAL A 242
ILE A  74
PHE A  70
 None
 1.15A 3freX-2o1bA:
undetectable		 3freX-2o1bA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		5 / 12 GLY A 129
GLY A 135
ALA A 104
LEU A 164
ILE A 110
 None
 1.05A 3ku1H-2o1bA:
3.6		 3ku1H-2o1bA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		5 / 12 GLY A 204
VAL A 242
TYR A  78
ASN A 279
LEU A 285
 None
 1.44A 4a83A-2o1bA:
undetectable		 4a83A-2o1bA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		4 / 7 PHE A 190
THR A 162
LEU A 167
VAL A 154
 None
 0.97A 4cp4A-2o1bA:
undetectable		 4cp4A-2o1bA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		4 / 6 ILE A  74
TYR A  82
TYR A 229
PHE A 244
 None
 1.21A 4g10A-2o1bA:
undetectable		 4g10A-2o1bA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		4 / 8 PHE A 190
THR A 162
LEU A 167
VAL A 154
 None
 0.95A 4l4aA-2o1bA:
undetectable		 4l4aA-2o1bA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		5 / 12 TYR A 126
ALA A 202
ASN A 212
GLY A 204
ASN A 172
 None
PLP  A 400 (-3.5A)
None
None
PLP  A 400 (-4.0A)
 1.20A 4obwD-2o1bA:
3.1		 4obwD-2o1bA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		3 / 3 GLU A 352
TYR A  13
GLU A 330
 None
 0.81A 4ryaA-2o1bA:
undetectable		 4ryaA-2o1bA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		4 / 6 PHE A 206
GLY A 204
TYR A 203
ALA A 202
 None
None
PLP  A 400 (-4.2A)
PLP  A 400 (-3.5A)
 1.20A 4yshB-2o1bA:
undetectable		 4yshB-2o1bA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		4 / 5 ALA A 380
TYR A 381
PRO A 325
PHE A 335
 None
 1.23A 4ze2A-2o1bA:
undetectable		 4ze2A-2o1bA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		4 / 6 SER A 289
GLY A 204
ASN A 212
ILE A 317
 None
 0.95A 5j4nA-2o1bA:
undetectable		 5j4nA-2o1bA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		5 / 12 PHE A  70
ILE A  45
ALA A 277
LEU A 278
ALA A  73
 None
 1.08A 5oy02-2o1bA:
undetectable		 5oy02-2o1bA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		4 / 8 LEU A 308
VAL A 319
LEU A 321
ILE A 360
 None
 0.58A 6cb4A-2o1bA:
undetectable		 6cb4A-2o1bA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		3 / 3 HIS A 280
ASN A 279
LEU A 278
 None
 0.90A 6f7lB-2o1bA:
undetectable		 6f7lB-2o1bA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 2o1b AMINOTRANSFERASE,
CLASS I
(Staphylococcus
aureus) 		5 / 12 TYR A 229
THR A  98
TYR A 203
VAL A 291
GLY A  39
 None
PLP  A 400 (-3.0A)
PLP  A 400 (-4.2A)
None
None
 1.49A 6gngB-2o1bA:
undetectable		 6gngB-2o1bA:
25.24