SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o1e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 2o1e YCDH
(Bacillus
subtilis) 		4 / 8 TYR A 280
PHE A  29
PHE A  23
LEU A 131
 None
 1.17A 1ea1A-2o1eA:
undetectable		 1ea1A-2o1eA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 2o1e YCDH
(Bacillus
subtilis) 		5 / 9 THR A 190
ALA A 199
TYR A 202
LEU A 204
LEU A 135
 None
 1.34A 2azqA-2o1eA:
undetectable		 2azqA-2o1eA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2o1e YCDH
(Bacillus
subtilis) 		3 / 3 ASP A 153
ASN A 154
THR A 144
 None
 0.72A 2q63B-2o1eA:
undetectable		 2q63B-2o1eA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2o1e YCDH
(Bacillus
subtilis) 		5 / 12 ALA A 244
LEU A 252
ILE A 189
LEU A 226
LEU A 212
 None
 1.11A 3k2hA-2o1eA:
undetectable		 3k2hA-2o1eA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 2o1e YCDH
(Bacillus
subtilis) 		4 / 7 SER A 132
VAL A 129
TRP A 130
PHE A  29
 None
 1.34A 3n5tA-2o1eA:
undetectable
3n5tB-2o1eA:
undetectable		 3n5tA-2o1eA:
20.22
3n5tB-2o1eA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 2o1e YCDH
(Bacillus
subtilis) 		4 / 7 THR A  21
LEU A  17
VAL A  95
VAL A  70
 None
 0.97A 4cp4A-2o1eA:
undetectable		 4cp4A-2o1eA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 2o1e YCDH
(Bacillus
subtilis) 		4 / 6 ARG A 177
ALA A 180
ASP A 173
LEU A 204
 None
 1.15A 4ot2A-2o1eA:
2.6		 4ot2A-2o1eA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 2o1e YCDH
(Bacillus
subtilis) 		4 / 7 PHE A  29
SER A 132
VAL A 129
TRP A 130
 None
 1.33A 5adlA-2o1eA:
undetectable
5adlB-2o1eA:
undetectable		 5adlA-2o1eA:
19.43
5adlB-2o1eA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2o1e YCDH
(Bacillus
subtilis) 		4 / 7 PHE A  29
SER A 132
VAL A 129
TRP A 130
 None
 1.30A 5fj3A-2o1eA:
undetectable
5fj3B-2o1eA:
undetectable		 5fj3A-2o1eA:
19.43
5fj3B-2o1eA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 2o1e YCDH
(Bacillus
subtilis) 		5 / 12 LEU A 131
LEU A 291
ILE A 283
TYR A 239
THR A 190
 None
 0.88A 5ienB-2o1eA:
undetectable		 5ienB-2o1eA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 2o1e YCDH
(Bacillus
subtilis) 		5 / 12 LEU A 295
LEU A 131
LEU A 291
ILE A 283
TYR A 239
 None
 1.20A 5ienB-2o1eA:
undetectable		 5ienB-2o1eA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2o1e YCDH
(Bacillus
subtilis) 		4 / 7 PHE A  29
SER A 132
VAL A 129
TRP A 130
 None
 1.30A 5vv7A-2o1eA:
undetectable
5vv7B-2o1eA:
undetectable		 5vv7A-2o1eA:
19.43
5vv7B-2o1eA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2o1e YCDH
(Bacillus
subtilis) 		4 / 7 SER A 132
VAL A 129
TRP A 130
PHE A  29
 None
 1.29A 6av6A-2o1eA:
undetectable
6av6B-2o1eA:
undetectable		 6av6A-2o1eA:
13.33
6av6B-2o1eA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2o1e YCDH
(Bacillus
subtilis) 		4 / 7 PHE A  29
SER A 132
VAL A 129
TRP A 130
 None
 1.32A 6av6C-2o1eA:
undetectable
6av6D-2o1eA:
1.1		 6av6C-2o1eA:
13.33
6av6D-2o1eA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 2o1e YCDH
(Bacillus
subtilis) 		4 / 6 VAL A 262
ASN A 264
ILE A 283
GLU A 273
 None
 1.23A 6h7uA-2o1eA:
undetectable		 6h7uA-2o1eA:
19.48