SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o1o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		3 / 3 MET A 148
LEU A 151
SER A 152
 None
 0.44A 1ee2A-2o1oA:
undetectable		 1ee2A-2o1oA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 11 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.40A 1rqjA-2o1oA:
25.8		 1rqjA-2o1oA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 11 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.41A 1rqjB-2o1oA:
25.8		 1rqjB-2o1oA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 7 ILE A 355
GLY A 247
PHE A 249
TYR A 214
 None
 0.84A 1rtsB-2o1oA:
undetectable		 1rtsB-2o1oA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		9 / 11 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
TYR A 214
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
None
RIS  A 400 (-3.1A)
 0.42A 1yhlA-2o1oA:
36.8		 1yhlA-2o1oA:
27.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		9 / 11 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
TYR A 214
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
None
RIS  A 400 (-3.1A)
 0.42A 1yq7A-2o1oA:
35.7		 1yq7A-2o1oA:
32.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.37A 1yv5A-2o1oA:
36.0		 1yv5A-2o1oA:
32.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.40A 1zw5A-2o1oA:
36.1		 1zw5A-2o1oA:
29.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 8 ILE A  74
PHE A 216
LEU A 347
ILE A 348
 None
 0.91A 2azxA-2o1oA:
undetectable		 2azxA-2o1oA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.44A 2e91A-2o1oA:
24.1		 2e91A-2o1oA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.57A 2e91B-2o1oA:
23.2		 2e91B-2o1oA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
LYS A 210
THR A 211
TYR A 214
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
None
RIS  A 400 (-3.1A)
 0.44A 2f89F-2o1oA:
36.7		 2f89F-2o1oA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		9 / 11 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
TYR A 214
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
None
RIS  A 400 (-3.1A)
 0.41A 2f8cF-2o1oA:
36.1		 2f8cF-2o1oA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.46A 2f8zF-2o1oA:
36.3		 2f8zF-2o1oA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 12 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
GLN A 184
LYS A 210
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
 0.71A 2f94F-2o1oA:
36.0		 2f94F-2o1oA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		9 / 12 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
LYS A 210
THR A 211
TYR A 214
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
None
RIS  A 400 (-3.1A)
 0.41A 2f94F-2o1oA:
36.0		 2f94F-2o1oA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.38A 2f9kF-2o1oA:
36.3		 2f9kF-2o1oA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		3 / 3 HIS A 253
ILE A 351
LEU A 325
 None
 0.56A 2kceA-2o1oA:
undetectable		 2kceA-2o1oA:
22.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 10 LEU A 112
ASP A 115
ARG A 124
GLN A 184
ASP A 268
 None
MG  A 503 (-2.5A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
MG  A 501 ( 4.8A)
 0.99A 2q58A-2o1oA:
50.1		 2q58A-2o1oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		10 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
ASN A 254
ASP A 255
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
RIS  A 400 ( 2.3A)
None
 0.46A 2q58A-2o1oA:
50.1		 2q58A-2o1oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
ASN A 254
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
RIS  A 400 ( 2.3A)
 0.47A 2q58B-2o1oA:
45.3		 2q58B-2o1oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 9 ASP A 115
ASP A 119
GLN A 184
LYS A 210
LYS A 273
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
MG  A 502 ( 4.5A)
 1.49A 2q58B-2o1oA:
45.3		 2q58B-2o1oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
 0.36A 2qisA-2o1oA:
36.2		 2qisA-2o1oA:
32.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 7 ILE A 355
GLY A 247
PHE A 249
TYR A 214
 None
 0.78A 2tsrA-2o1oA:
undetectable		 2tsrA-2o1oA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 8 ILE A 355
GLY A 247
PHE A 249
TYR A 214
 None
 0.77A 2tsrB-2o1oA:
undetectable		 2tsrB-2o1oA:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.55A 3ez3A-2o1oA:
37.4		 3ez3A-2o1oA:
35.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.39A 3ez3B-2o1oA:
36.6		 3ez3B-2o1oA:
35.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.52A 3ez3C-2o1oA:
37.4		 3ez3C-2o1oA:
35.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.42A 3ez3D-2o1oA:
36.4		 3ez3D-2o1oA:
35.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
 1.23A 3ez3D-2o1oA:
36.4		 3ez3D-2o1oA:
35.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
TYR A 214
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
None
RIS  A 400 (-3.1A)
 0.48A 3ibaA-2o1oA:
36.7		 3ibaA-2o1oA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		3 / 3 ASN A 262
ASP A 268
ARG A  75
 None
MG  A 501 ( 4.8A)
None
 0.71A 3k13A-2o1oA:
undetectable		 3k13A-2o1oA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		3 / 3 ALA A 266
ARG A 271
LYS A 273
 None
None
MG  A 502 ( 4.5A)
 1.03A 3kp3B-2o1oA:
2.7		 3kp3B-2o1oA:
20.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.55A 3ldwA-2o1oA:
37.3		 3ldwA-2o1oA:
35.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.42A 3ldwB-2o1oA:
36.7		 3ldwB-2o1oA:
35.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.52A 3ldwC-2o1oA:
37.3		 3ldwC-2o1oA:
35.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.44A 3ldwD-2o1oA:
36.5		 3ldwD-2o1oA:
35.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		9 / 11 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
TYR A 214
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
None
RIS  A 400 (-3.1A)
 0.39A 3n45F-2o1oA:
36.5		 3n45F-2o1oA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.37A 3n46F-2o1oA:
36.1		 3n46F-2o1oA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 7 ASP A 116
ASP A 115
TYR A 214
ARG A  75
 None
MG  A 503 (-2.5A)
None
None
 1.30A 3s3oA-2o1oA:
undetectable		 3s3oA-2o1oA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 5 TYR A 217
ILE A 143
LEU A 146
LYS A 147
 None
 1.05A 3sueC-2o1oA:
undetectable		 3sueC-2o1oA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		6 / 12 ILE A 169
PHE A 161
LEU A 100
VAL A 103
LEU A 157
ILE A  38
 None
 1.32A 4g1bD-2o1oA:
undetectable		 4g1bD-2o1oA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 7 ILE A 355
GLY A 247
PHE A 249
TYR A 214
 None
 0.79A 4iqqA-2o1oA:
undetectable		 4iqqA-2o1oA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 7 ILE A 355
GLY A 247
PHE A 249
TYR A 214
 None
 0.76A 4iqqC-2o1oA:
undetectable		 4iqqC-2o1oA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 8 ILE A 355
GLY A 247
PHE A 249
TYR A 214
 None
 0.85A 4iqqD-2o1oA:
undetectable		 4iqqD-2o1oA:
19.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
 0.36A 4kfaA-2o1oA:
35.7		 4kfaA-2o1oA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.37A 4kpdA-2o1oA:
35.8		 4kpdA-2o1oA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 LEU A 112
ASP A 115
ASP A 119
ARG A 124
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.34A 4kpjA-2o1oA:
35.7		 4kpjA-2o1oA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 9 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
 1.23A 4kpjA-2o1oA:
35.7		 4kpjA-2o1oA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.37A 4kq5A-2o1oA:
35.9		 4kq5A-2o1oA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.34A 4kqsA-2o1oA:
35.8		 4kqsA-2o1oA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
GLN A 184
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
RIS  A 400 ( 3.5A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.35A 4n9uA-2o1oA:
35.7		 4n9uA-2o1oA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 211
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 (-3.7A)
 1.25A 4n9uA-2o1oA:
35.7		 4n9uA-2o1oA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 12 LEU A 112
ARG A 124
GLN A 251
THR A 215
TYR A 214
 None
RIS  A 400 (-2.9A)
RIS  A 400 (-3.1A)
None
None
 1.39A 4ng6A-2o1oA:
35.9		 4ng6A-2o1oA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 12 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
GLN A 184
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
RIS  A 400 ( 3.5A)
RIS  A 400 (-3.1A)
 0.63A 4ng6A-2o1oA:
35.9		 4ng6A-2o1oA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 12 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
THR A 211
TYR A 214
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
RIS  A 400 (-3.7A)
None
RIS  A 400 (-3.1A)
 0.40A 4ng6A-2o1oA:
35.9		 4ng6A-2o1oA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 12 LEU A 112
ASP A 115
ASP A 119
THR A 211
GLN A 184
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-3.7A)
RIS  A 400 ( 3.5A)
 1.38A 4ng6A-2o1oA:
35.9		 4ng6A-2o1oA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.38A 4nkeA-2o1oA:
35.5		 4nkeA-2o1oA:
32.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
 1.24A 4nkeA-2o1oA:
35.5		 4nkeA-2o1oA:
32.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 LEU A 112
ASP A 115
ASP A 119
ARG A 124
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.40A 4nkfA-2o1oA:
35.7		 4nkfA-2o1oA:
32.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.36A 4nuaA-2o1oA:
35.7		 4nuaA-2o1oA:
32.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
 1.23A 4nuaA-2o1oA:
35.7		 4nuaA-2o1oA:
32.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 LEU A 112
ASP A 115
ASP A 119
ARG A 124
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.39A 4oguA-2o1oA:
35.6		 4oguA-2o1oA:
32.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.39A 4p0vA-2o1oA:
36.3		 4p0vA-2o1oA:
29.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		9 / 11 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
TYR A 214
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
None
RIS  A 400 (-3.1A)
 0.41A 4p0wA-2o1oA:
36.6		 4p0wA-2o1oA:
29.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
TYR A 214
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
None
RIS  A 400 (-3.1A)
 0.41A 4q23A-2o1oA:
35.7		 4q23A-2o1oA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.40A 4rxdA-2o1oA:
36.6		 4rxdA-2o1oA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
 1.18A 4rxdA-2o1oA:
36.6		 4rxdA-2o1oA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.41A 4rxdB-2o1oA:
36.7		 4rxdB-2o1oA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
 1.20A 4rxdB-2o1oA:
36.7		 4rxdB-2o1oA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.41A 4rxdC-2o1oA:
36.7		 4rxdC-2o1oA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
 1.19A 4rxdC-2o1oA:
36.7		 4rxdC-2o1oA:
30.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		6 / 8 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
 0.70A 4umjA-2o1oA:
22.4		 4umjA-2o1oA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
 0.58A 4umjB-2o1oA:
22.5		 4umjB-2o1oA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 9 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
 1.19A 4umjB-2o1oA:
22.5		 4umjB-2o1oA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		10 / 12 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
GLN A 184
LYS A 210
THR A 211
TYR A 214
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
None
RIS  A 400 (-3.1A)
 0.37A 5cg5A-2o1oA:
36.1		 5cg5A-2o1oA:
28.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 12 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
 1.21A 5cg6A-2o1oA:
36.6		 5cg6A-2o1oA:
28.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		9 / 12 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.33A 5cg6A-2o1oA:
36.6		 5cg6A-2o1oA:
28.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		6 / 9 LEU A 112
ASP A 115
ASP A 119
ARG A 124
LYS A 210
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
 0.66A 5eroA-2o1oA:
24.7		 5eroA-2o1oA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		6 / 9 ASP A 115
ASP A 119
ARG A 124
LYS A 210
GLN A 251
ASP A 255
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
None
 0.57A 5eroB-2o1oA:
24.5		 5eroB-2o1oA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 10 ASP A 115
ASP A 116
ASP A 119
ARG A 124
LYS A 210
GLN A 251
ASP A 255
 MG  A 503 (-2.5A)
None
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
None
 0.63A 5eroC-2o1oA:
24.7		 5eroC-2o1oA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 7 ILE A 355
GLY A 247
PHE A 249
TYR A 214
 None
 0.85A 5h3aA-2o1oA:
undetectable		 5h3aA-2o1oA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 7 ILE A 355
GLY A 247
PHE A 249
TYR A 214
 None
 0.80A 5nooA-2o1oA:
undetectable		 5nooA-2o1oA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 7 ILE A 355
GLY A 247
PHE A 249
TYR A 214
 None
 0.88A 5nooB-2o1oA:
undetectable		 5nooB-2o1oA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 8 ILE A 355
GLY A 247
PHE A 249
TYR A 214
 None
 0.88A 5nooD-2o1oA:
undetectable		 5nooD-2o1oA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 7 ILE A 355
GLY A 247
PHE A 249
TYR A 214
 None
 0.80A 5x5qC-2o1oA:
undetectable		 5x5qC-2o1oA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		3 / 3 ASN A  30
VAL A  68
HIS A  73
 None
 0.83A 6a5yD-2o1oA:
undetectable		 6a5yD-2o1oA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 12 PRO A 219
ILE A 177
VAL A 103
VAL A 104
LEU A 151
 None
 1.02A 6b52A-2o1oA:
undetectable		 6b52A-2o1oA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		6 / 7 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
 0.99A 6g31A-2o1oA:
24.6		 6g31A-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_B_ZOLB401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 6 ASP A 115
ASP A 119
ARG A 124
GLN A 184
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-3.1A)
 0.83A 6g31B-2o1oA:
24.5		 6g31B-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 5 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
 1.02A 6g31C-2o1oA:
24.2		 6g31C-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		6 / 7 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-3.1A)
 0.65A 6g31D-2o1oA:
24.0		 6g31D-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_E_ZOLE401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 4 LEU A 112
ASP A 115
ASP A 119
ARG A 124
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
 0.43A 6g31E-2o1oA:
15.8		 6g31E-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 5 ASP A 115
ASP A 119
ARG A 124
GLN A 184
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-3.1A)
 0.84A 6g31F-2o1oA:
24.3		 6g31F-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		6 / 7 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
 0.65A 6g31G-2o1oA:
23.9		 6g31G-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_H_ZOLH401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 5 ASP A 115
ASP A 119
GLN A 184
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-3.1A)
 0.62A 6g31H-2o1oA:
23.5		 6g31H-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_I_ZOLI401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 4 ASP A 115
ASP A 119
LYS A 210
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
 0.86A 6g31I-2o1oA:
23.6		 6g31I-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 6 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
 0.87A 6g31J-2o1oA:
24.7		 6g31J-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 6 LEU A 112
ASP A 115
ASP A 119
GLN A 184
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-3.1A)
 0.64A 6g31J-2o1oA:
24.7		 6g31J-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_K_ZOLK401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 4 ASP A 115
ASP A 119
ARG A 124
GLN A 184
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
 0.46A 6g31K-2o1oA:
23.2		 6g31K-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 6 ASP A 115
ASP A 119
ARG A 124
GLN A 184
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
 0.67A 6g31L-2o1oA:
24.3		 6g31L-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 6 ASP A 115
ASP A 119
GLN A 184
GLN A 251
LYS A 273
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-3.1A)
MG  A 502 ( 4.5A)
 1.28A 6g31L-2o1oA:
24.3		 6g31L-2o1oA:
12.85