SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 2o1t ENDOPLASMIN
(Canis
lupus) 		4 / 7 PHE A 512
VAL A 496
GLY A 495
VAL A 572
 None
 0.72A 1p2yA-2o1tA:
undetectable		 1p2yA-2o1tA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 2o1t ENDOPLASMIN
(Canis
lupus) 		4 / 8 LEU A 580
ARG A 503
ALA A 507
LYS A 508
 None
 0.63A 2xfsA-2o1tA:
undetectable		 2xfsA-2o1tA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 2o1t ENDOPLASMIN
(Canis
lupus) 		4 / 8 LEU A 580
ARG A 503
ALA A 507
LYS A 508
 None
 0.64A 2xh9A-2o1tA:
undetectable		 2xh9A-2o1tA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2o1t ENDOPLASMIN
(Canis
lupus) 		5 / 12 LEU A 640
SER A 643
SER A 725
LEU A 627
LEU A 618
 None
 1.30A 2zlcA-2o1tA:
undetectable		 2zlcA-2o1tA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2o1t ENDOPLASMIN
(Canis
lupus) 		4 / 5 PHE A 718
TYR A 727
LEU A 693
ARG A 724
 None
 1.18A 3sudD-2o1tA:
undetectable		 3sudD-2o1tA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2o1t ENDOPLASMIN
(Canis
lupus) 		5 / 12 LEU A 640
SER A 643
ARG A 724
SER A 725
LEU A 627
 None
 1.11A 3vt7A-2o1tA:
undetectable		 3vt7A-2o1tA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 2o1t ENDOPLASMIN
(Canis
lupus) 		4 / 4 ASN A 657
ALA A 542
GLY A 543
THR A 569
 None
 1.22A 4bboC-2o1tA:
undetectable		 4bboC-2o1tA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2o1t ENDOPLASMIN
(Canis
lupus) 		4 / 8 ILE A 373
PRO A 427
VAL A 433
MET A 425
 None
 1.27A 4f4dB-2o1tA:
undetectable		 4f4dB-2o1tA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 2o1t ENDOPLASMIN
(Canis
lupus) 		5 / 12 LEU A 627
LYS A 633
ALA A 714
PHE A 718
MET A 697
 None
 1.13A 4i1rA-2o1tA:
undetectable		 4i1rA-2o1tA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2o1t ENDOPLASMIN
(Canis
lupus) 		4 / 8 PHE A 383
ILE A 460
PHE A 375
LEU A 430
 None
 0.84A 5hs1A-2o1tA:
undetectable		 5hs1A-2o1tA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2o1t ENDOPLASMIN
(Canis
lupus) 		5 / 10 PHE A 685
LEU A 647
THR A 684
SER A 637
ILE A 687
 None
 1.20A 6ebpB-2o1tA:
undetectable		 6ebpB-2o1tA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2o1t ENDOPLASMIN
(Canis
lupus) 		4 / 8 ASP A 520
HIS A 517
GLU A 564
GLU A 529
 None
 1.19A 6mn4A-2o1tA:
undetectable		 6mn4A-2o1tA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2o1t ENDOPLASMIN
(Canis
lupus) 		4 / 8 ASP A 520
HIS A 517
GLU A 564
GLU A 529
 None
 1.17A 6mn4B-2o1tA:
undetectable		 6mn4B-2o1tA:
19.30