SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o1v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 2o1v ENDOPLASMIN
(Canis
lupus) 		3 / 3 GLU A 224
ILE A 210
ARG A 237
 None
 0.81A 1cd2A-2o1vA:
undetectable		 1cd2A-2o1vA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 2o1v ENDOPLASMIN
(Canis
lupus) 		3 / 3 PHE A 598
LEU A 558
MET A 541
 None
 0.82A 1mx1D-2o1vA:
undetectable		 1mx1D-2o1vA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 2o1v ENDOPLASMIN
(Canis
lupus) 		4 / 7 PHE A 512
VAL A 496
GLY A 495
VAL A 572
 None
 0.77A 1p2yA-2o1vA:
undetectable		 1p2yA-2o1vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2o1v ENDOPLASMIN
(Canis
lupus) 		3 / 3 ILE A 210
ASP A 207
PHE A 203
 None
 0.59A 1uwjB-2o1vA:
undetectable		 1uwjB-2o1vA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2o1v ENDOPLASMIN
(Canis
lupus) 		3 / 3 VAL A 205
VAL A 250
ASP A 149
 None
None
ADP  A 301 (-3.9A)
 0.75A 2fumD-2o1vA:
undetectable		 2fumD-2o1vA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 2o1v ENDOPLASMIN
(Canis
lupus) 		4 / 7 LEU A 249
ILE A 247
ASN A 107
PHE A 199
 None
None
MG  A 755 ( 2.7A)
None
 0.88A 2opxA-2o1vA:
undetectable		 2opxA-2o1vA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 2o1v ENDOPLASMIN
(Canis
lupus) 		4 / 8 LEU A 580
ARG A 503
ALA A 507
LYS A 508
 None
 0.82A 2xfsA-2o1vA:
undetectable		 2xfsA-2o1vA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 2o1v ENDOPLASMIN
(Canis
lupus) 		4 / 8 LEU A 580
ARG A 503
ALA A 507
LYS A 508
 None
 0.90A 2xh9A-2o1vA:
undetectable		 2xh9A-2o1vA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2o1v ENDOPLASMIN
(Canis
lupus) 		4 / 8 GLY A 244
ASN A 216
ILE A 115
ALA A 111
 None
None
None
ADP  A 301 (-3.4A)
 0.95A 3aodA-2o1vA:
undetectable		 3aodA-2o1vA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 2o1v ENDOPLASMIN
(Canis
lupus) 		4 / 7 GLU A 365
GLU A 487
PHE A 488
PRO A 390
 None
 1.09A 3ql6A-2o1vA:
undetectable		 3ql6A-2o1vA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2o1v ENDOPLASMIN
(Canis
lupus) 		4 / 5 PHE A 718
TYR A 727
LEU A 693
ARG A 724
 None
 1.26A 3sudD-2o1vA:
0.0		 3sudD-2o1vA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 2o1v ENDOPLASMIN
(Canis
lupus) 		4 / 6 ASN A 239
GLY A 238
ASP A 235
ILE A 222
 None
 0.70A 3w9tF-2o1vA:
undetectable		 3w9tF-2o1vA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 2o1v ENDOPLASMIN
(Canis
lupus) 		4 / 4 ASN A 657
ALA A 542
GLY A 543
THR A 569
 None
 1.22A 4bboC-2o1vA:
undetectable		 4bboC-2o1vA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 2o1v ENDOPLASMIN
(Canis
lupus) 		5 / 12 LEU A 627
LYS A 633
ALA A 714
PHE A 718
MET A 697
 None
 1.14A 4i1rA-2o1vA:
undetectable		 4i1rA-2o1vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2o1v ENDOPLASMIN
(Canis
lupus) 		4 / 8 LEU A 163
VAL A 211
ILE A 247
MET A 154
 None
None
None
ADP  A 301 (-3.6A)
 0.89A 4oj4A-2o1vA:
undetectable		 4oj4A-2o1vA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 2o1v ENDOPLASMIN
(Canis
lupus) 		3 / 3 GLU A 157
THR A 219
HIS A 221
 None
 0.71A 4q15A-2o1vA:
undetectable		 4q15A-2o1vA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 2o1v ENDOPLASMIN
(Canis
lupus) 		3 / 3 GLU A 157
THR A 219
HIS A 221
 None
 0.67A 4q15B-2o1vA:
undetectable		 4q15B-2o1vA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 2o1v ENDOPLASMIN
(Canis
lupus) 		3 / 3 GLU A 157
THR A 219
HIS A 221
 None
 0.72A 4ydqB-2o1vA:
undetectable		 4ydqB-2o1vA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 2o1v ENDOPLASMIN
(Canis
lupus) 		3 / 3 ARG A 156
THR A 219
ASP A 218
 None
 0.85A 5g5gA-2o1vA:
undetectable
5g5gB-2o1vA:
undetectable		 5g5gA-2o1vA:
16.04
5g5gB-2o1vA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2o1v ENDOPLASMIN
(Canis
lupus) 		4 / 7 ILE A 492
GLY A 489
ASP A 573
PHE A 540
 None
 0.98A 5hieA-2o1vA:
undetectable		 5hieA-2o1vA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2o1v ENDOPLASMIN
(Canis
lupus) 		4 / 8 PHE A 383
ILE A 460
PHE A 375
LEU A 430
 None
 0.87A 5hs1A-2o1vA:
undetectable		 5hs1A-2o1vA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 2o1v ENDOPLASMIN
(Canis
lupus) 		4 / 7 GLY A 153
SER A 109
PHE A 277
LEU A 132
 ADP  A 301 ( 4.4A)
None
None
None
 0.88A 5izfA-2o1vA:
undetectable		 5izfA-2o1vA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2o1v ENDOPLASMIN
(Canis
lupus) 		3 / 3 VAL A 232
SER A 231
TRP A 223
 None
 1.04A 5jwaA-2o1vA:
undetectable		 5jwaA-2o1vA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2o1v ENDOPLASMIN
(Canis
lupus) 		3 / 3 LYS A 208
LEU A 163
ILE A 247
 None
 0.74A 5kc4A-2o1vA:
undetectable		 5kc4A-2o1vA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 2o1v ENDOPLASMIN
(Canis
lupus) 		4 / 6 LEU A 619
THR A 684
ARG A 724
PRO A 553
 None
 1.05A 6ew0G-2o1vA:
undetectable		 6ew0G-2o1vA:
9.03