SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o1w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 2o1w ENDOPLASMIN
(Canis
lupus) 		5 / 12 THR A 248
LEU A 104
LEU A 101
LEU A 163
LEU A 159
 None
 1.23A 1errB-2o1wA:
undetectable		 1errB-2o1wA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2o1w ENDOPLASMIN
(Canis
lupus) 		3 / 3 THR A 490
GLU A 487
ASP A 367
 None
 0.78A 1nt2A-2o1wA:
undetectable		 1nt2A-2o1wA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2o1w ENDOPLASMIN
(Canis
lupus) 		3 / 3 VAL A 205
VAL A 250
ASP A 149
 None
 0.72A 2fumD-2o1wA:
undetectable		 2fumD-2o1wA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2o1w ENDOPLASMIN
(Canis
lupus) 		3 / 3 ASP A 257
TYR A 258
LYS A  97
 None
 1.18A 2othA-2o1wA:
undetectable		 2othA-2o1wA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2o1w ENDOPLASMIN
(Canis
lupus) 		4 / 8 TYR A 258
LEU A 259
LEU A 251
LYS A 252
 None
 1.08A 2wekA-2o1wA:
undetectable		 2wekA-2o1wA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 2o1w ENDOPLASMIN
(Canis
lupus) 		4 / 8 LEU A 580
ARG A 503
ALA A 507
LYS A 508
 None
 0.78A 2xfsA-2o1wA:
undetectable		 2xfsA-2o1wA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 2o1w ENDOPLASMIN
(Canis
lupus) 		4 / 8 LEU A 580
ARG A 503
ALA A 507
LYS A 508
 None
 0.89A 2xh9A-2o1wA:
undetectable		 2xh9A-2o1wA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2o1w ENDOPLASMIN
(Canis
lupus) 		4 / 8 GLY A 244
ASN A 216
ILE A 115
ALA A 111
 None
 0.97A 3aodA-2o1wA:
undetectable		 3aodA-2o1wA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 2o1w ENDOPLASMIN
(Canis
lupus) 		3 / 3 ARG A 448
ILE A 115
THR A 155
 None
 0.70A 3ia4D-2o1wA:
undetectable		 3ia4D-2o1wA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 2o1w ENDOPLASMIN
(Canis
lupus) 		4 / 6 SER A 363
ASP A 367
TYR A 359
PRO A 394
 None
 1.43A 3jqaC-2o1wA:
undetectable		 3jqaC-2o1wA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 2o1w ENDOPLASMIN
(Canis
lupus) 		4 / 6 SER A 363
ASP A 367
TYR A 359
PRO A 394
 None
 1.43A 3jqaD-2o1wA:
undetectable		 3jqaD-2o1wA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 2o1w ENDOPLASMIN
(Canis
lupus) 		4 / 7 GLU A 365
GLU A 487
PHE A 488
PRO A 390
 None
 1.03A 3ql6A-2o1wA:
undetectable		 3ql6A-2o1wA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2o1w ENDOPLASMIN
(Canis
lupus) 		4 / 4 LEU A 241
GLY A 242
GLY A 244
THR A 150
 None
 0.85A 3si7A-2o1wA:
undetectable		 3si7A-2o1wA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 2o1w ENDOPLASMIN
(Canis
lupus) 		4 / 6 ASN A 239
GLY A 238
ASP A 235
ILE A 222
 None
 0.63A 3w9tF-2o1wA:
undetectable		 3w9tF-2o1wA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 2o1w ENDOPLASMIN
(Canis
lupus) 		4 / 7 GLU A 498
ASP A 499
ASN A 502
ILE A 492
 None
 1.21A 4ii8A-2o1wA:
undetectable		 4ii8A-2o1wA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2o1w ENDOPLASMIN
(Canis
lupus) 		4 / 8 LEU A 163
VAL A 211
ILE A 247
MET A 154
 None
 0.94A 4oj4A-2o1wA:
undetectable		 4oj4A-2o1wA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2o1w ENDOPLASMIN
(Canis
lupus) 		4 / 8 PHE A 383
ILE A 460
PHE A 375
LEU A 430
 None
 0.84A 5hs1A-2o1wA:
undetectable		 5hs1A-2o1wA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 2o1w ENDOPLASMIN
(Canis
lupus) 		3 / 3 CYH A 138
LYS A 137
HIS A 146
 None
 1.21A 5js5A-2o1wA:
undetectable		 5js5A-2o1wA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2o1w ENDOPLASMIN
(Canis
lupus) 		3 / 3 VAL A 232
SER A 231
TRP A 223
 None
 1.03A 5jwaA-2o1wA:
undetectable		 5jwaA-2o1wA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2o1w ENDOPLASMIN
(Canis
lupus) 		4 / 7 GLY A 151
ALA A 108
ASP A 113
ASN A 129
 None
 0.89A 5mvsA-2o1wA:
undetectable		 5mvsA-2o1wA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2o1w ENDOPLASMIN
(Canis
lupus) 		4 / 8 GLY A 151
ALA A 108
ASP A 113
ASN A 129
 None
 0.88A 5mvsB-2o1wA:
undetectable		 5mvsB-2o1wA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 2o1w ENDOPLASMIN
(Canis
lupus) 		3 / 3 LEU A 510
ASP A 477
ILE A 475
 None
 0.62A 6dh0B-2o1wA:
undetectable		 6dh0B-2o1wA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2o1w ENDOPLASMIN
(Canis
lupus) 		3 / 3 LEU A 159
GLY A 164
PHE A 203
 None
 0.60A 6exiC-2o1wA:
undetectable		 6exiC-2o1wA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 2o1w ENDOPLASMIN
(Canis
lupus) 		4 / 8 TYR A 412
VAL A 436
PRO A 341
ILE A 342
 None
 1.12A 6hzpA-2o1wA:
undetectable		 6hzpA-2o1wA:
21.93