SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o1z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 2o1z RIBONUCLEOTIDE
REDUCTASE SUBUNIT R2
(Plasmodium
vivax) 		4 / 7 THR A 135
ASN A 142
TYR A 143
LEU A  91
 None
 1.07A 1qzrA-2o1zA:
undetectable		 1qzrA-2o1zA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 2o1z RIBONUCLEOTIDE
REDUCTASE SUBUNIT R2
(Plasmodium
vivax) 		4 / 7 THR A 135
ASN A 142
TYR A 143
LEU A  91
 None
 1.01A 1qzrB-2o1zA:
undetectable		 1qzrB-2o1zA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2o1z RIBONUCLEOTIDE
REDUCTASE SUBUNIT R2
(Plasmodium
vivax) 		5 / 11 HIS A 132
GLU A 191
PHE A 199
ILE A 221
GLU A 225
 None
FE  A1000 (-3.6A)
None
None
FE  A1000 (-2.4A)
 0.84A 1rnrA-2o1zA:
27.3		 1rnrA-2o1zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2o1z RIBONUCLEOTIDE
REDUCTASE SUBUNIT R2
(Plasmodium
vivax) 		5 / 11 HIS A 132
SER A 198
PHE A 199
ILE A 221
GLU A 225
 None
None
None
None
FE  A1000 (-2.4A)
 0.83A 1rnrA-2o1zA:
27.3		 1rnrA-2o1zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2o1z RIBONUCLEOTIDE
REDUCTASE SUBUNIT R2
(Plasmodium
vivax) 		5 / 12 HIS A 132
GLU A 191
PHE A 199
ILE A 221
GLU A 225
 None
FE  A1000 (-3.6A)
None
None
FE  A1000 (-2.4A)
 0.75A 1rnrB-2o1zA:
27.3		 1rnrB-2o1zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2o1z RIBONUCLEOTIDE
REDUCTASE SUBUNIT R2
(Plasmodium
vivax) 		5 / 12 HIS A 132
TYR A 136
GLU A 191
ILE A 221
GLU A 225
 None
None
FE  A1000 (-3.6A)
None
FE  A1000 (-2.4A)
 0.77A 1rnrB-2o1zA:
27.3		 1rnrB-2o1zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 2o1z RIBONUCLEOTIDE
REDUCTASE SUBUNIT R2
(Plasmodium
vivax) 		5 / 11 THR A 135
VAL A 128
ARG A 223
ILE A 221
ASP A 224
 None
 1.43A 1t6zB-2o1zA:
undetectable		 1t6zB-2o1zA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2o1z RIBONUCLEOTIDE
REDUCTASE SUBUNIT R2
(Plasmodium
vivax) 		5 / 11 ASN A 250
VAL A 247
TYR A 236
ALA A 181
SER A 179
 None
 1.30A 2iyfA-2o1zA:
undetectable		 2iyfA-2o1zA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2o1z RIBONUCLEOTIDE
REDUCTASE SUBUNIT R2
(Plasmodium
vivax) 		5 / 12 ASN A 250
VAL A 247
TYR A 236
ALA A 181
SER A 179
 None
 1.31A 2iyfB-2o1zA:
undetectable		 2iyfB-2o1zA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 2o1z RIBONUCLEOTIDE
REDUCTASE SUBUNIT R2
(Plasmodium
vivax) 		4 / 8 ILE A  32
ILE A 184
PHE A 180
VAL A  50
 None
None
None
UNX  A2001 (-4.3A)
 0.82A 3ua5A-2o1zA:
undetectable		 3ua5A-2o1zA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2o1z RIBONUCLEOTIDE
REDUCTASE SUBUNIT R2
(Plasmodium
vivax) 		5 / 12 PHE A 203
SER A 217
HIS A 132
TYR A 136
LEU A  91
 None
 1.29A 3vn2A-2o1zA:
undetectable		 3vn2A-2o1zA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2o1z RIBONUCLEOTIDE
REDUCTASE SUBUNIT R2
(Plasmodium
vivax) 		4 / 6 ARG A 183
ILE A 251
VAL A 247
LEU A 243
 None
 1.01A 4em2A-2o1zA:
0.8		 4em2A-2o1zA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2o1z RIBONUCLEOTIDE
REDUCTASE SUBUNIT R2
(Plasmodium
vivax) 		5 / 11 ASN A 250
VAL A 247
TYR A 236
ALA A 181
SER A 179
 None
 1.31A 4m83A-2o1zA:
undetectable		 4m83A-2o1zA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_B_ERYB501_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2o1z RIBONUCLEOTIDE
REDUCTASE SUBUNIT R2
(Plasmodium
vivax) 		5 / 11 ASN A 250
VAL A 247
TYR A 236
ALA A 181
SER A 179
 None
 1.29A 4m83B-2o1zA:
undetectable		 4m83B-2o1zA:
20.85