SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o20'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 2o20 CATABOLITE CONTROL
PROTEIN A
(Lactococcus
lactis) 		4 / 6 TYR A 185
GLU A 204
ILE A 325
GLY A 274
 None
 1.13A 1maaB-2o20A:
3.1
1maaD-2o20A:
3.7		 1maaB-2o20A:
20.90
1maaD-2o20A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 2o20 CATABOLITE CONTROL
PROTEIN A
(Lactococcus
lactis) 		5 / 9 THR A 331
ILE A 183
VAL A 244
SER A 242
GLU A 270
 None
 1.19A 1nb9A-2o20A:
undetectable		 1nb9A-2o20A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2o20 CATABOLITE CONTROL
PROTEIN A
(Lactococcus
lactis) 		3 / 3 LYS A 173
ILE A 272
THR A 241
 None
 0.83A 1rx3A-2o20A:
undetectable		 1rx3A-2o20A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 2o20 CATABOLITE CONTROL
PROTEIN A
(Lactococcus
lactis) 		5 / 12 LEU A 319
ILE A  81
GLY A  84
ILE A  88
VAL A 160
 None
 0.93A 2nnkB-2o20A:
undetectable		 2nnkB-2o20A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 2o20 CATABOLITE CONTROL
PROTEIN A
(Lactococcus
lactis) 		5 / 11 LEU A 319
VAL A 148
GLY A  84
ILE A  88
VAL A 160
 None
 1.00A 2nnpB-2o20A:
undetectable		 2nnpB-2o20A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_H_BEZH2001_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 2o20 CATABOLITE CONTROL
PROTEIN A
(Lactococcus
lactis) 		5 / 10 GLN A 227
GLY A 228
LEU A 254
ASN A 222
PHE A 219
 None
None
None
None
SO4  A2007 (-4.8A)
 1.40A 2ok6A-2o20A:
undetectable
2ok6H-2o20A:
undetectable		 2ok6A-2o20A:
25.00
2ok6H-2o20A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 2o20 CATABOLITE CONTROL
PROTEIN A
(Lactococcus
lactis) 		5 / 11 VAL A 124
ILE A 134
SER A 129
THR A 150
LYS A 191
 None
 1.32A 3bjwE-2o20A:
undetectable		 3bjwE-2o20A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 2o20 CATABOLITE CONTROL
PROTEIN A
(Lactococcus
lactis) 		5 / 10 LEU A 319
VAL A 148
ILE A  81
GLY A  84
ILE A  88
 None
 1.17A 3el5A-2o20A:
undetectable		 3el5A-2o20A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 2o20 CATABOLITE CONTROL
PROTEIN A
(Lactococcus
lactis) 		5 / 10 LEU A 319
VAL A 148
GLY A  84
ILE A  88
VAL A 160
 None
 1.05A 3nu9B-2o20A:
undetectable		 3nu9B-2o20A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 2o20 CATABOLITE CONTROL
PROTEIN A
(Lactococcus
lactis) 		6 / 12 LEU A 319
VAL A 148
ILE A  81
GLY A  84
ILE A  88
VAL A 160
 None
 1.18A 3so9B-2o20A:
undetectable		 3so9B-2o20A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 2o20 CATABOLITE CONTROL
PROTEIN A
(Lactococcus
lactis) 		4 / 7 GLY A  84
ILE A  88
VAL A 146
VAL A 160
 None
 0.72A 3ufnB-2o20A:
undetectable		 3ufnB-2o20A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 2o20 CATABOLITE CONTROL
PROTEIN A
(Lactococcus
lactis) 		5 / 9 VAL A 218
ALA A 184
TYR A 185
GLY A 221
SER A 246
 None
 1.40A 4mmeA-2o20A:
undetectable		 4mmeA-2o20A:
21.11