SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o26'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2o26 KIT LIGAND
MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus) 		3 / 3 LEU X 125
PHE X 201
ARG A 104
 None
 0.66A 1xdkB-2o26X:
undetectable		 1xdkB-2o26X:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2o26 KIT LIGAND
MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus) 		3 / 3 LEU X 125
PHE X 201
ARG A 104
 None
 0.66A 1xdkF-2o26X:
undetectable		 1xdkF-2o26X:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 2o26 MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus) 		5 / 12 LEU X 134
ALA X 133
LEU X 149
LEU X 183
PHE X 126
 None
 1.46A 2oaxF-2o26X:
undetectable		 2oaxF-2o26X:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2o26 KIT LIGAND
MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus;
Mus
musculus) 		4 / 6 THR X 277
ASP A  10
THR A   9
ASP A  14
 None
 1.30A 2okcB-2o26X:
undetectable		 2okcB-2o26X:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 2o26 KIT LIGAND
MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus;
Mus
musculus) 		5 / 12 ILE A  50
ASP A  47
VAL A  87
GLU X  74
PRO X 124
 None
 1.28A 2yzqA-2o26A:
undetectable		 2yzqA-2o26A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2o26 MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus) 		4 / 5 GLN X 275
THR X 277
THR X 306
HIS X 222
 None
 1.27A 2zj0A-2o26X:
undetectable		 2zj0A-2o26X:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2o26 MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus) 		4 / 5 GLN X 275
THR X 277
THR X 306
HIS X 222
 None
 1.34A 2zj0B-2o26X:
undetectable		 2zj0B-2o26X:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2o26 MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus) 		4 / 5 GLN X 275
THR X 277
THR X 306
HIS X 222
 None
 1.25A 2zj0C-2o26X:
undetectable		 2zj0C-2o26X:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 2o26 MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus) 		3 / 3 PRO X 167
LEU X 139
ARG X 113
 None
 0.92A 3aqiA-2o26X:
undetectable		 3aqiA-2o26X:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2o26 MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus) 		4 / 5 GLN X 275
THR X 277
THR X 306
HIS X 222
 None
 1.30A 3ce6A-2o26X:
undetectable		 3ce6A-2o26X:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2o26 MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus) 		4 / 5 GLN X 275
THR X 277
THR X 306
HIS X 222
 None
 1.28A 3ce6B-2o26X:
undetectable		 3ce6B-2o26X:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2o26 MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus) 		4 / 5 GLN X 275
THR X 277
THR X 306
HIS X 222
 None
 1.28A 3ce6C-2o26X:
undetectable		 3ce6C-2o26X:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 2o26 MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus) 		4 / 5 GLN X 275
THR X 277
THR X 306
HIS X 222
 None
 1.30A 3g1uC-2o26X:
undetectable		 3g1uC-2o26X:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 2o26 MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus) 		4 / 5 GLN X 275
THR X 277
THR X 306
HIS X 222
 None
 1.24A 3glqA-2o26X:
undetectable		 3glqA-2o26X:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 2o26 MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus) 		4 / 5 GLN X 275
THR X 277
THR X 306
HIS X 222
 None
 1.30A 3glqB-2o26X:
undetectable		 3glqB-2o26X:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2o26 MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus) 		4 / 5 GLN X 275
THR X 277
THR X 306
HIS X 222
 None
 1.31A 3n58A-2o26X:
undetectable		 3n58A-2o26X:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2o26 KIT LIGAND
(Mus
musculus) 		4 / 8 ILE A  15
VAL A  49
LEU A  52
PHE A 116
 None
 0.94A 4r38B-2o26A:
undetectable		 4r38B-2o26A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2o26 MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus) 		3 / 3 VAL X  76
THR X  70
ARG X  92
 None
 0.46A 5b2sB-2o26X:
undetectable		 5b2sB-2o26X:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2o26 MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus) 		3 / 3 VAL X  76
THR X  70
ARG X  92
 None
 0.43A 5b2tB-2o26X:
undetectable		 5b2tB-2o26X:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2o26 KIT LIGAND
MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus) 		5 / 12 VAL X  76
GLU X  74
SER A 101
ARG A 104
LEU X 120
 None
 1.29A 5m50B-2o26X:
undetectable		 5m50B-2o26X:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2o26 KIT LIGAND
MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus) 		5 / 12 VAL X  76
GLU X  74
SER A 101
ARG A 104
LEU X 120
 None
 1.28A 5m50E-2o26X:
undetectable		 5m50E-2o26X:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2o26 KIT LIGAND
(Mus
musculus) 		5 / 12 LEU A  59
VAL A   8
ILE A  82
ASP A  84
ASP A  85
 None
 1.25A 6bxnA-2o26A:
undetectable		 6bxnA-2o26A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_A_ADNA505_2
(-)		 2o26 MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus) 		4 / 4 GLN X 275
THR X 277
THR X 306
HIS X 222
 None
 1.26A 6f3nA-2o26X:
undetectable		 6f3nA-2o26X:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_2
(-)		 2o26 MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus) 		4 / 4 GLN X 275
THR X 277
THR X 306
HIS X 222
 None
 1.26A 6f3nC-2o26X:
undetectable		 6f3nC-2o26X:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_D_ADND506_2
(-)		 2o26 MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Mus
musculus) 		4 / 4 GLN X 275
THR X 277
THR X 306
HIS X 222
 None
 1.25A 6f3nD-2o26X:
undetectable		 6f3nD-2o26X:
20.37