SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o2c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 LEU A 534
ILE A 542
GLY A 540
ALA A 541
LEU A  91
 None
 1.03A 1cqeA-2o2cA:
undetectable		 1cqeA-2o2cA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 LEU A 534
ILE A 542
GLY A 540
ALA A 541
LEU A  91
 None
 1.03A 1cqeB-2o2cA:
undetectable		 1cqeB-2o2cA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 11 ALA A 273
THR A 252
HIS A 199
ILE A 203
ALA A 276
 None
 1.06A 1gtnM-2o2cA:
undetectable
1gtnN-2o2cA:
undetectable		 1gtnM-2o2cA:
9.57
1gtnN-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 273
THR A 252
HIS A 199
ILE A 203
ALA A 276
 None
 1.01A 1gtnU-2o2cA:
undetectable
1gtnV-2o2cA:
undetectable		 1gtnU-2o2cA:
9.57
1gtnV-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 ALA A 374
VAL A 376
TRP A 379
 None
 0.90A 1tkqB-2o2cA:
undetectable		 1tkqB-2o2cA:
3.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 LEU A 398
ALA A 541
ILE A 356
ILE A 391
LEU A 405
 None
 1.04A 1tw4A-2o2cA:
undetectable		 1tw4A-2o2cA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 ALA A 273
THR A 252
HIS A 199
ILE A 203
ALA A 276
 None
 1.02A 1utdL-2o2cA:
undetectable
1utdM-2o2cA:
undetectable		 1utdL-2o2cA:
9.57
1utdM-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 HIS A 230
ALA A 273
THR A 252
HIS A 199
ILE A 203
 None
 0.93A 1utdL-2o2cA:
undetectable
1utdM-2o2cA:
undetectable		 1utdL-2o2cA:
9.57
1utdM-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 ALA A 273
THR A 252
HIS A 199
ILE A 203
ALA A 276
 None
 1.04A 1utdO-2o2cA:
undetectable
1utdP-2o2cA:
undetectable		 1utdO-2o2cA:
9.57
1utdP-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_Q_TRPQ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 HIS A 230
ALA A 273
THR A 252
HIS A 199
ILE A 203
 None
 1.00A 1utdQ-2o2cA:
undetectable
1utdR-2o2cA:
undetectable		 1utdQ-2o2cA:
9.57
1utdR-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 273
THR A 252
HIS A 199
ILE A 203
ALA A 276
 None
 1.05A 1utdT-2o2cA:
undetectable
1utdU-2o2cA:
undetectable		 1utdT-2o2cA:
9.57
1utdU-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 11 HIS A 230
ALA A 273
THR A 252
HIS A 199
ILE A 203
 None
 0.97A 1utdL-2o2cA:
undetectable
1utdV-2o2cA:
undetectable		 1utdL-2o2cA:
9.57
1utdV-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 GLY A 342
GLU A 182
ASN A 345
 None
 0.71A 1zq9A-2o2cA:
1.9		 1zq9A-2o2cA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 LEU A 534
ILE A 542
GLY A 540
ALA A 541
LEU A  91
 None
 0.99A 2aylB-2o2cA:
0.0		 2aylB-2o2cA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 ALA A 538
LEU A  99
ILE A 460
LEU A 405
ILE A 543
 None
 0.88A 2cd2A-2o2cA:
undetectable		 2cd2A-2o2cA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 7 GLY A 437
PHE A 444
ILE A 448
PHE A 433
 None
 1.02A 2qmzA-2o2cA:
3.5
2qmzB-2o2cA:
3.5		 2qmzA-2o2cA:
17.76
2qmzB-2o2cA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 ILE A 255
ALA A 257
ILE A 337
LEU A 299
VAL A 184
 None
 1.07A 3dzuA-2o2cA:
undetectable		 3dzuA-2o2cA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 ILE A 255
ALA A 257
LEU A 299
VAL A 184
LEU A 229
 None
 1.13A 3dzuA-2o2cA:
undetectable		 3dzuA-2o2cA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 ILE A 255
ALA A 257
LEU A 299
VAL A 184
LEU A 229
 None
 1.12A 3dzyA-2o2cA:
undetectable		 3dzyA-2o2cA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 ASN A 413
GLY A 554
ARG A 419
ASP A 409
GLY A 377
 None
 1.15A 3k13A-2o2cA:
undetectable		 3k13A-2o2cA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 ASN A 413
GLY A 554
ARG A 419
ASP A 409
GLY A 377
 None
 1.14A 3k13B-2o2cA:
undetectable		 3k13B-2o2cA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 ASN A 413
GLY A 554
ARG A 419
ASP A 409
GLY A 377
 None
 1.15A 3k13C-2o2cA:
undetectable		 3k13C-2o2cA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 8 ILE A 337
PRO A 336
SER A 328
GLY A 334
 None
 0.90A 3lslA-2o2cA:
undetectable
3lslD-2o2cA:
undetectable		 3lslA-2o2cA:
18.35
3lslD-2o2cA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 8 ILE A 337
PRO A 336
SER A 328
GLY A 334
 None
 0.90A 3lslA-2o2cA:
undetectable
3lslD-2o2cA:
undetectable		 3lslA-2o2cA:
18.35
3lslD-2o2cA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 LEU A 534
ILE A 542
GLY A 540
ALA A 541
LEU A  91
 None
 1.00A 3n8zB-2o2cA:
0.1		 3n8zB-2o2cA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ARG A 123
ILE A 125
LEU A 371
LEU A 375
VAL A 378
 None
 0.75A 3o02A-2o2cA:
undetectable
3o02B-2o2cA:
undetectable		 3o02A-2o2cA:
20.23
3o02B-2o2cA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 7 LYS A 259
LEU A 408
VAL A 550
LEU A 151
 None
 0.95A 3rgfA-2o2cA:
undetectable		 3rgfA-2o2cA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 6 ILE A 543
ARG A 537
THR A 535
LEU A 534
 None
 1.02A 3wg7N-2o2cA:
undetectable
3wg7W-2o2cA:
undetectable		 3wg7N-2o2cA:
20.47
3wg7W-2o2cA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 ARG A  81
HIS A  74
TYR A  85
 GOL  A7001 (-4.0A)
GOL  A7001 ( 4.8A)
GOL  A7001 (-4.1A)
 1.17A 4fu9A-2o2cA:
undetectable		 4fu9A-2o2cA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 276
ALA A 273
THR A 252
HIS A 199
ILE A 203
 None
 1.09A 5eeuF-2o2cA:
undetectable
5eeuG-2o2cA:
undetectable		 5eeuF-2o2cA:
9.57
5eeuG-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 ALA A 276
ALA A 273
THR A 252
HIS A 199
ILE A 203
 None
 1.07A 5eeuI-2o2cA:
undetectable
5eeuJ-2o2cA:
undetectable		 5eeuI-2o2cA:
9.57
5eeuJ-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 273
THR A 252
HIS A 199
ILE A 203
ALA A 276
 None
 1.04A 5eeuO-2o2cA:
undetectable
5eeuP-2o2cA:
undetectable		 5eeuO-2o2cA:
9.57
5eeuP-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 273
THR A 252
HIS A 199
ILE A 203
ALA A 276
 None
 1.06A 5eeuQ-2o2cA:
undetectable
5eeuR-2o2cA:
undetectable		 5eeuQ-2o2cA:
9.57
5eeuR-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 276
ALA A 273
THR A 252
HIS A 199
ILE A 203
 None
 1.09A 5eevF-2o2cA:
undetectable
5eevG-2o2cA:
undetectable		 5eevF-2o2cA:
9.57
5eevG-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 ALA A 276
ALA A 273
THR A 252
HIS A 199
ILE A 203
 None
 1.07A 5eevI-2o2cA:
undetectable
5eevJ-2o2cA:
undetectable		 5eevI-2o2cA:
9.57
5eevJ-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 273
THR A 252
HIS A 199
ILE A 203
ALA A 276
 None
 1.04A 5eevO-2o2cA:
undetectable
5eevP-2o2cA:
undetectable		 5eevO-2o2cA:
9.57
5eevP-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 273
THR A 252
HIS A 199
ILE A 203
ALA A 276
 None
 1.05A 5eevQ-2o2cA:
undetectable
5eevR-2o2cA:
undetectable		 5eevQ-2o2cA:
9.57
5eevR-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 276
ALA A 273
THR A 252
HIS A 199
ILE A 203
 None
 1.08A 5eewF-2o2cA:
undetectable
5eewG-2o2cA:
undetectable		 5eewF-2o2cA:
9.57
5eewG-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 ALA A 276
ALA A 273
THR A 252
HIS A 199
ILE A 203
 None
 1.07A 5eewI-2o2cA:
undetectable
5eewJ-2o2cA:
undetectable		 5eewI-2o2cA:
9.57
5eewJ-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 273
THR A 252
HIS A 199
ILE A 203
ALA A 276
 None
 1.03A 5eewO-2o2cA:
undetectable
5eewP-2o2cA:
undetectable		 5eewO-2o2cA:
9.57
5eewP-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 273
THR A 252
HIS A 199
ILE A 203
ALA A 276
 None
 1.05A 5eewQ-2o2cA:
undetectable
5eewR-2o2cA:
undetectable		 5eewQ-2o2cA:
9.57
5eewR-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 276
ALA A 273
THR A 252
HIS A 199
ILE A 203
 None
 1.08A 5eexF-2o2cA:
undetectable
5eexG-2o2cA:
undetectable		 5eexF-2o2cA:
9.57
5eexG-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 273
THR A 252
HIS A 199
ILE A 203
ALA A 276
 None
 1.03A 5eexO-2o2cA:
undetectable
5eexP-2o2cA:
undetectable		 5eexO-2o2cA:
9.57
5eexP-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 276
ALA A 273
THR A 252
HIS A 199
ILE A 203
 None
 1.08A 5eeyF-2o2cA:
undetectable
5eeyG-2o2cA:
undetectable		 5eeyF-2o2cA:
9.57
5eeyG-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 273
THR A 252
HIS A 199
ILE A 203
ALA A 276
 None
 1.03A 5eeyO-2o2cA:
undetectable
5eeyP-2o2cA:
undetectable		 5eeyO-2o2cA:
9.57
5eeyP-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 276
ALA A 273
THR A 252
HIS A 199
ILE A 203
 None
 1.08A 5eezF-2o2cA:
undetectable
5eezG-2o2cA:
undetectable		 5eezF-2o2cA:
9.57
5eezG-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 273
THR A 252
HIS A 199
ILE A 203
ALA A 276
 None
 1.03A 5eezO-2o2cA:
undetectable
5eezP-2o2cA:
undetectable		 5eezO-2o2cA:
9.57
5eezP-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 276
ALA A 273
THR A 252
HIS A 199
ILE A 203
 None
 1.08A 5ef0F-2o2cA:
undetectable
5ef0G-2o2cA:
undetectable		 5ef0F-2o2cA:
9.57
5ef0G-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 273
THR A 252
HIS A 199
ILE A 203
ALA A 276
 None
 1.03A 5ef0O-2o2cA:
undetectable
5ef0P-2o2cA:
undetectable		 5ef0O-2o2cA:
9.57
5ef0P-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 276
ALA A 273
THR A 252
HIS A 199
ILE A 203
 None
 1.07A 5ef1F-2o2cA:
undetectable
5ef1G-2o2cA:
undetectable		 5ef1F-2o2cA:
9.57
5ef1G-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 273
THR A 252
HIS A 199
ILE A 203
ALA A 276
 None
 1.03A 5ef1O-2o2cA:
undetectable
5ef1P-2o2cA:
undetectable		 5ef1O-2o2cA:
9.57
5ef1P-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 276
ALA A 273
THR A 252
HIS A 199
ILE A 203
 None
 1.07A 5ef2F-2o2cA:
undetectable
5ef2G-2o2cA:
undetectable		 5ef2F-2o2cA:
9.57
5ef2G-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 273
THR A 252
HIS A 199
ILE A 203
ALA A 276
 None
 1.03A 5ef2O-2o2cA:
undetectable
5ef2P-2o2cA:
undetectable		 5ef2O-2o2cA:
9.57
5ef2P-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 276
ALA A 273
THR A 252
HIS A 199
ILE A 203
 None
 1.07A 5ef3F-2o2cA:
undetectable
5ef3G-2o2cA:
undetectable		 5ef3F-2o2cA:
9.57
5ef3G-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ALA A 273
THR A 252
HIS A 199
ILE A 203
ALA A 276
 None
 1.02A 5ef3O-2o2cA:
undetectable
5ef3P-2o2cA:
undetectable		 5ef3O-2o2cA:
9.57
5ef3P-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 VAL A 378
ALA A 374
ARG A 419
LYS A 549
SER A 561
 None
 1.32A 5hgcA-2o2cA:
undetectable		 5hgcA-2o2cA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 GLY A 324
GLY A 325
GLN A 564
 G6Q  A5001 ( 4.8A)
G6Q  A5001 (-3.5A)
G6Q  A5001 (-3.7A)
 0.37A 5imsA-2o2cA:
4.5		 5imsA-2o2cA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 THR A 216
PHE A 254
ALA A 273
SER A 208
ILE A 205
 None
None
None
G6Q  A5001 (-2.7A)
None
 1.35A 5iwuA-2o2cA:
undetectable		 5iwuA-2o2cA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 LEU A 534
GLY A 211
ALA A 218
LEU A 398
GLY A 334
 None
 0.98A 5kb5A-2o2cA:
undetectable		 5kb5A-2o2cA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 GLY A 554
ILE A 556
THR A 426
VAL A 424
LEU A 375
 None
 1.14A 5nz0A-2o2cA:
1.1		 5nz0A-2o2cA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 GLY A 352
ALA A 544
HIS A 548
PRO A 536
THR A 351
 None
 1.08A 5x6yC-2o2cA:
2.5		 5x6yC-2o2cA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 LEU A 210
THR A 266
ASN A 269
 None
G6Q  A5001 ( 4.7A)
None
 0.71A 6baaE-2o2cA:
undetectable		 6baaE-2o2cA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 LEU A 210
THR A 266
ASN A 269
 None
G6Q  A5001 ( 4.7A)
None
 0.71A 6baaF-2o2cA:
2.1		 6baaF-2o2cA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 LEU A 210
THR A 266
ASN A 269
 None
G6Q  A5001 ( 4.7A)
None
 0.71A 6baaG-2o2cA:
undetectable		 6baaG-2o2cA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 LEU A 210
THR A 266
ASN A 269
 None
G6Q  A5001 ( 4.7A)
None
 0.72A 6baaH-2o2cA:
undetectable		 6baaH-2o2cA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 6 SER A 208
ALA A 332
SER A 331
ALA A 257
 G6Q  A5001 (-2.7A)
None
None
None
 0.77A 6bocA-2o2cA:
undetectable
6bocB-2o2cA:
undetectable
6bocC-2o2cA:
undetectable
6bocD-2o2cA:
undetectable		 6bocA-2o2cA:
5.47
6bocB-2o2cA:
5.47
6bocC-2o2cA:
5.47
6bocD-2o2cA:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 ARG A 326
SER A 131
PHE A 128
VAL A 550
ASP A 560
 G6Q  A5001 (-3.9A)
None
None
None
None
 1.28A 6clxA-2o2cA:
2.7		 6clxA-2o2cA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_B_SAMB401_0
(O-METHYLTRANSFERASE)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ARG A 326
SER A 131
PHE A 128
VAL A 550
ASP A 560
 G6Q  A5001 (-3.9A)
None
None
None
None
 1.28A 6clxB-2o2cA:
2.9		 6clxB-2o2cA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 LEU A 349
GLY A 334
PHE A 231
 None
 0.65A 6exiC-2o2cA:
3.6		 6exiC-2o2cA:
10.56