SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o2f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I7Z_A_COCA301_1 (CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION)	2o2f	APOPTOSIS REGULATOR BCL-2 (Homo sapiens)	4 / 8	TYR A 199 LEU A 94 GLU A 197 TRP A 192	LI0 A1000 (-3.4A) None None None	1.02A	1i7zA-2o2fA: undetectable	1i7zA-2o2fA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX1_E_THAE5_2 (LIVER CARBOXYLESTERASE I)	2o2f	APOPTOSIS REGULATOR BCL-2 (Homo sapiens)	3 / 3	PHE A 148 LEU A 178 LEU A 182	None	0.54A	1mx1E-2o2fA: undetectable	1mx1E-2o2fA: 13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VUF_A_FUAA2002_1 (SERUM ALBUMIN)	2o2f	APOPTOSIS REGULATOR BCL-2 (Homo sapiens)	4 / 9	PHE A 127 ALA A 128 VAL A 131 GLU A 132	None	0.55A	2vufA-2o2fA: 3.0	2vufA-2o2fA: 12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LK0_D_Z80D92_1 (PROTEIN S100-B)	2o2f	APOPTOSIS REGULATOR BCL-2 (Homo sapiens)	3 / 3	HIS A 183 PHE A 147 PHE A 148	None	0.61A	3lk0D-2o2fA: undetectable	3lk0D-2o2fA: 19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6QYA_B_FOZB401_0 (THYMIDYLATE SYNTHASE)	2o2f	APOPTOSIS REGULATOR BCL-2 (Homo sapiens)	5 / 12	LEU A 116 LEU A 21 PHE A 150 ILE A 170 ALA A 171	None None LI0 A1000 ( 4.4A) None None	1.43A	6qyaB-2o2fA: undetectable	6qyaB-2o2fA: 20.07

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1I7Z_A_COCA301_1","CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION","2o2f","APOPTOSIS REGULATOR BCL-2","Homo sapiens",4,"TYR A 199;LEU A  94;GLU A 197;TRP A 192","LI0 A1000 (-3.4A);None;None;None","1.02A","1i7zA-2o2fA:undetectable","1i7zA-2o2fA:20.00"],["1MX1_E_THAE5_2","LIVER CARBOXYLESTERASE I","2o2f","APOPTOSIS REGULATOR BCL-2","Homo sapiens",3,"PHE A 148;LEU A 178;LEU A 182","None","0.54A","1mx1E-2o2fA:undetectable","1mx1E-2o2fA:13.40"],["2VUF_A_FUAA2002_1","SERUM ALBUMIN","2o2f","APOPTOSIS REGULATOR BCL-2","Homo sapiens",4,"PHE A 127;ALA A 128;VAL A 131;GLU A 132","None","0.55A","2vufA-2o2fA:3.0","2vufA-2o2fA:12.59"],["3LK0_D_Z80D92_1","PROTEIN S100-B","2o2f","APOPTOSIS REGULATOR BCL-2","Homo sapiens",3,"HIS A 183;PHE A 147;PHE A 148","None","0.61A","3lk0D-2o2fA:undetectable","3lk0D-2o2fA:19.40"],["6QYA_B_FOZB401_0","THYMIDYLATE SYNTHASE","2o2f","APOPTOSIS REGULATOR BCL-2","Homo sapiens",5,"LEU A 116;LEU A  21;PHE A 150;ILE A 170;ALA A 171","None;None;LI0 A1000 ( 4.4A);None;None","1.43A","6qyaB-2o2fA:undetectable","6qyaB-2o2fA:20.07"]]