SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o2g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		5 / 12 GLY A 124
VAL A 129
SER A 121
HIS A  41
LEU A  68
 None
 1.33A 1kiaD-2o2gA:
2.4		 1kiaD-2o2gA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		5 / 12 LEU A 221
LEU A  59
ALA A 208
ALA A 210
VAL A  37
 None
 1.30A 1kt4A-2o2gA:
undetectable		 1kt4A-2o2gA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		4 / 8 PHE A 200
SER A 143
ALA A 120
ASN A  52
 None
None
SO4  A 223 (-3.6A)
SO4  A 223 (-3.3A)
 0.98A 1pnlA-2o2gA:
undetectable
1pnlB-2o2gA:
undetectable		 1pnlA-2o2gA:
21.25
1pnlB-2o2gA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		5 / 12 LEU A 221
LEU A  59
ALA A 208
ALA A 210
VAL A  37
 None
 1.16A 1rbpA-2o2gA:
undetectable		 1rbpA-2o2gA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		4 / 8 ALA A 131
LEU A 128
GLY A 125
GLY A 119
 None
 0.84A 1rukH-2o2gA:
undetectable
1rukL-2o2gA:
undetectable		 1rukH-2o2gA:
22.88
1rukL-2o2gA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		4 / 8 SER A  95
ARG A  96
LEU A  72
GLU A  76
 None
 0.82A 2cdqA-2o2gA:
undetectable		 2cdqA-2o2gA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		4 / 7 SER A  95
ARG A  96
LEU A  72
GLU A  76
 None
 0.80A 2cdqB-2o2gA:
undetectable		 2cdqB-2o2gA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		5 / 12 ALA A  65
LEU A  27
LEU A 104
VAL A 115
ILE A  69
 None
 1.13A 3datA-2o2gA:
undetectable		 3datA-2o2gA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		5 / 12 PHE A 217
LEU A  64
GLY A  32
GLY A  35
LEU A 221
 None
 1.15A 3e23A-2o2gA:
3.1		 3e23A-2o2gA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		5 / 12 ILE A 193
ILE A 165
GLY A 119
LEU A 206
ARG A  51
 None
None
None
None
SO4  A 223 (-3.8A)
 1.06A 3em0B-2o2gA:
undetectable		 3em0B-2o2gA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		3 / 3 LEU A 190
LEU A 164
ARG A 147
 None
 0.71A 3hcnB-2o2gA:
4.1		 3hcnB-2o2gA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		5 / 11 ALA A  65
LEU A  27
LEU A 104
VAL A 115
ILE A  69
 None
 1.28A 3jw5A-2o2gA:
undetectable		 3jw5A-2o2gA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		4 / 7 LEU A  93
LEU A  72
SER A  46
ASP A  80
 None
 0.76A 3lm8A-2o2gA:
2.5
3lm8C-2o2gA:
undetectable		 3lm8A-2o2gA:
20.60
3lm8C-2o2gA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		4 / 8 ASP A  80
LEU A  93
LEU A  72
SER A  46
 None
 0.93A 3lm8A-2o2gA:
2.4
3lm8C-2o2gA:
undetectable		 3lm8A-2o2gA:
20.60
3lm8C-2o2gA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		4 / 8 ASP A  80
LEU A  93
LEU A  72
SER A  46
 None
 0.84A 3lm8B-2o2gA:
3.7
3lm8D-2o2gA:
undetectable		 3lm8B-2o2gA:
20.60
3lm8D-2o2gA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		5 / 11 PRO A 108
ASP A 109
ASN A 107
VAL A  14
ALA A  13
 None
None
None
EDO  A 225 (-4.9A)
EDO  A 225 (-3.7A)
 1.41A 3n23A-2o2gA:
undetectable		 3n23A-2o2gA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		5 / 11 PRO A 108
ASP A 109
ASN A 107
VAL A  14
ALA A  13
 None
None
None
EDO  A 225 (-4.9A)
EDO  A 225 (-3.7A)
 1.41A 3n23C-2o2gA:
3.8		 3n23C-2o2gA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		3 / 3 ASN A  52
ALA A 120
ARG A 144
 SO4  A 223 (-3.3A)
SO4  A 223 (-3.6A)
SO4  A 223 (-3.1A)
 0.59A 3tj7C-2o2gA:
undetectable
3tj7D-2o2gA:
undetectable		 3tj7C-2o2gA:
21.22
3tj7D-2o2gA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		6 / 12 LEU A 184
GLY A 119
GLY A 124
VAL A 141
THR A 162
LEU A 164
 None
 1.09A 4dc3B-2o2gA:
6.0		 4dc3B-2o2gA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		3 / 3 LEU A  93
LEU A  67
ASN A  52
 None
None
SO4  A 223 (-3.3A)
 0.68A 4otwA-2o2gA:
undetectable		 4otwA-2o2gA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		5 / 10 ALA A  56
VAL A  58
ILE A 165
VAL A 142
PHE A 118
 None
 1.21A 5nukA-2o2gA:
undetectable		 5nukA-2o2gA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		4 / 5 HIS A 198
ALA A 120
SER A 121
GLY A 146
 None
SO4  A 223 (-3.6A)
None
None
 1.28A 5yodB-2o2gA:
undetectable		 5yodB-2o2gA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		3 / 3 ALA A  94
VAL A 141
TYR A 117
 None
 0.63A 5zmqH-2o2gA:
undetectable		 5zmqH-2o2gA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2o2g DIENELACTONE
HYDROLASE
(Trichormus
variabilis) 		5 / 10 GLY A  32
ALA A  65
LEU A  64
GLY A  63
LEU A 184
 None
 1.24A 6hqbA-2o2gA:
undetectable
6hqbJ-2o2gA:
undetectable		 6hqbA-2o2gA:
17.96
6hqbJ-2o2gA:
14.91