SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o2k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 2o2k METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 9 TYR A1219
LEU A1141
VAL A1102
GLY A1030
THR A1199
 None
 1.26A 1dz8A-2o2kA:
undetectable		 1dz8A-2o2kA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 2o2k METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 9 TYR A1219
LEU A1141
VAL A1102
GLY A1030
THR A1199
 None
 1.29A 1dz8B-2o2kA:
undetectable		 1dz8B-2o2kA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 2o2k METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 8 TYR A1219
LEU A1141
VAL A1102
THR A1199
 None
 1.16A 1dz9A-2o2kA:
undetectable		 1dz9A-2o2kA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 2o2k METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 9 TYR A1219
LEU A1141
VAL A1102
GLY A1030
THR A1199
 None
 1.27A 1dz9B-2o2kA:
undetectable		 1dz9B-2o2kA:
22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 2o2k METHIONINE SYNTHASE
(Homo
sapiens) 		9 / 10 ASP A 974
ARG A1132
GLU A1135
ARG A1172
PRO A1173
ALA A1174
TYR A1177
PRO A1178
TYR A1227
 None
 0.50A 1mskA-2o2kA:
41.9		 1mskA-2o2kA:
49.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 2o2k METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 8 TYR A1219
LEU A1141
VAL A1102
THR A1199
 None
 1.16A 1o76B-2o2kA:
undetectable		 1o76B-2o2kA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2o2k METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 11 TYR A1219
LEU A1141
VAL A1102
GLY A1030
THR A1199
 None
 1.27A 2a1nA-2o2kA:
undetectable		 2a1nA-2o2kA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 2o2k METHIONINE SYNTHASE
(Homo
sapiens) 		3 / 3 ARG A1027
ASP A 965
ASP A 971
 None
 0.82A 2ejtA-2o2kA:
undetectable		 2ejtA-2o2kA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 2o2k METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 ALA A1101
GLY A1030
MET A1189
TYR A1219
LEU A1218
 None
 1.14A 3bxoA-2o2kA:
undetectable		 3bxoA-2o2kA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2o2k METHIONINE SYNTHASE
(Homo
sapiens) 		3 / 3 PRO A 931
LEU A 932
GLN A1068
 None
 0.51A 3hznG-2o2kA:
undetectable
3hznH-2o2kA:
3.3		 3hznG-2o2kA:
21.73
3hznH-2o2kA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2o2k METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 7 TYR A1227
LEU A1097
PHE A1100
VAL A1102
 None
 1.08A 3jwqC-2o2kA:
undetectable		 3jwqC-2o2kA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 2o2k METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 PHE A1220
TYR A1227
PRO A1175
ASP A1084
GLY A1064
 None
 1.37A 4j7xF-2o2kA:
undetectable		 4j7xF-2o2kA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 2o2k METHIONINE SYNTHASE
(Homo
sapiens) 		3 / 3 ASP A1182
TYR A1241
TRP A1255
 None
 1.41A 4p7nA-2o2kA:
undetectable		 4p7nA-2o2kA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 2o2k METHIONINE SYNTHASE
(Homo
sapiens) 		3 / 3 ARG A1172
GLU A1140
TYR A1219
 None
 0.96A 4r29D-2o2kA:
undetectable		 4r29D-2o2kA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2o2k METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 7 ALA A 935
ASP A1043
THR A1184
GLU A1185
 None
 0.89A 5bs8A-2o2kA:
undetectable
5bs8C-2o2kA:
undetectable
5bs8D-2o2kA:
undetectable		 5bs8A-2o2kA:
21.26
5bs8C-2o2kA:
21.26
5bs8D-2o2kA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2o2k METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 7 ALA A 935
ASP A1043
THR A1184
GLU A1185
 None
 0.85A 5btgA-2o2kA:
undetectable
5btgC-2o2kA:
undetectable
5btgD-2o2kA:
undetectable		 5btgA-2o2kA:
21.26
5btgC-2o2kA:
21.26
5btgD-2o2kA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 2o2k METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 9 TYR A1219
LEU A1141
VAL A1102
GLY A1030
THR A1199
 None
 1.36A 5cp4A-2o2kA:
undetectable		 5cp4A-2o2kA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2o2k METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 6 PHE A1062
PRO A1175
MET A1189
LEU A1082
 None
 1.38A 5dzka-2o2kA:
undetectable
5dzko-2o2kA:
undetectable		 5dzka-2o2kA:
21.13
5dzko-2o2kA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 2o2k METHIONINE SYNTHASE
(Homo
sapiens) 		10 / 11 ASP A 974
PRO A 977
ARG A1132
GLU A1135
ARG A1172
PRO A1173
ALA A1174
TYR A1177
PRO A1178
TYR A1227
 None
 0.55A 6bm5A-2o2kA:
41.9		 6bm5A-2o2kA:
49.57