SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o2q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		3 / 3 GLU A 732
LYS A 726
VAL A 728
 None
 1.00A 1l2iA-2o2qA:
undetectable		 1l2iA-2o2qA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 6 TYR A 863
GLY A 807
PHE A 806
SER A 805
 None
None
NAP  A 903 (-4.0A)
None
 1.34A 2a3cA-2o2qA:
undetectable		 2a3cA-2o2qA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		3 / 3 MET A 496
GLU A 507
ASN A 574
 None
None
NAP  A 903 (-3.3A)
 1.07A 3a27A-2o2qA:
4.9		 3a27A-2o2qA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 7 TRP A 477
VAL A 623
THR A 613
LEU A 492
 None
 1.16A 3arrA-2o2qA:
undetectable		 3arrA-2o2qA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 7 LYS A 757
ASN A 702
HIS A 522
ALA A 511
 None
 1.22A 3frqB-2o2qA:
undetectable		 3frqB-2o2qA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		5 / 10 ILE A 506
PHE A 530
ARG A 491
ALA A 616
ALA A 493
 None
 1.41A 3lw5B-2o2qA:
undetectable		 3lw5B-2o2qA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 5 LEU A 680
ALA A 835
PHE A 859
ASN A 706
 None
None
None
GOL  A   1 (-3.3A)
 1.17A 3uq6A-2o2qA:
3.7		 3uq6A-2o2qA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 4 LEU A 680
ALA A 835
PHE A 859
ASN A 706
 None
None
None
GOL  A   1 (-3.3A)
 1.27A 3vaqA-2o2qA:
2.1		 3vaqA-2o2qA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 4 LEU A 680
ALA A 835
PHE A 859
ASN A 706
 None
None
None
GOL  A   1 (-3.3A)
 1.21A 3vasA-2o2qA:
3.9		 3vasA-2o2qA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 8 ARG A 491
LEU A 488
ASP A 484
ILE A 480
 None
 0.98A 4k0bA-2o2qA:
undetectable		 4k0bA-2o2qA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 7 ASP A 639
SER A 638
HIS A 657
SER A 661
 None
NAP  A 903 ( 4.7A)
NAP  A 903 (-4.2A)
None
 0.86A 4k7gB-2o2qA:
undetectable		 4k7gB-2o2qA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		5 / 12 VAL A 623
ALA A 468
LEU A 626
LYS A 597
LEU A 607
 None
None
None
NAP  A 903 (-2.8A)
None
 1.09A 4ky8C-2o2qA:
undetectable		 4ky8C-2o2qA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		5 / 12 VAL A 623
ALA A 468
LEU A 626
LYS A 597
LEU A 607
 None
None
None
NAP  A 903 (-2.8A)
None
 1.15A 4ky8D-2o2qA:
undetectable		 4ky8D-2o2qA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		5 / 12 VAL A 623
ALA A 468
LEU A 626
LYS A 597
LEU A 607
 None
None
None
NAP  A 903 (-2.8A)
None
 1.12A 4ky8E-2o2qA:
undetectable		 4ky8E-2o2qA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 8 ARG A 814
SER A 698
VAL A 699
VAL A 724
 None
 0.97A 4mk4A-2o2qA:
undetectable		 4mk4A-2o2qA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		5 / 12 LEU A 889
ALA A 585
ILE A 540
GLY A 535
ALA A 534
 None
 1.06A 4nkxD-2o2qA:
undetectable		 4nkxD-2o2qA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		3 / 3 PRO A 627
LEU A 626
GLN A 457
 None
 0.71A 4pevB-2o2qA:
2.3		 4pevB-2o2qA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		5 / 9 TYR A 761
SER A 805
ILE A 809
GLY A 711
ALA A 710
 None
 1.20A 4r1zA-2o2qA:
undetectable		 4r1zA-2o2qA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 5 ARG A 781
GLY A 737
GLY A 747
PRO A 748
 SO4  A3024 (-2.9A)
None
None
None
 0.90A 4u9uA-2o2qA:
4.5		 4u9uA-2o2qA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 5 ARG A 781
GLY A 737
GLY A 747
PRO A 748
 SO4  A3024 (-2.9A)
None
None
None
 0.82A 4u9uB-2o2qA:
4.9		 4u9uB-2o2qA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 4 ASN A 706
SER A 678
ALA A 709
VAL A 699
 GOL  A   1 (-3.3A)
None
None
None
 1.32A 4x1kC-2o2qA:
2.7		 4x1kC-2o2qA:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		5 / 10 THR A 529
TRP A 582
PHE A 701
ASN A 864
LEU A 884
 None
None
GOL  A   1 ( 4.6A)
GOL  A   1 ( 4.5A)
None
 0.67A 5fhzC-2o2qA:
56.2		 5fhzC-2o2qA:
44.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 4 ASN A 706
SER A 678
ALA A 709
VAL A 699
 GOL  A   1 (-3.3A)
None
None
None
 1.30A 5nm5A-2o2qA:
0.8		 5nm5A-2o2qA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 6 ARG A 781
GLY A 747
PRO A 748
THR A 744
 SO4  A3024 (-2.9A)
None
None
None
 0.87A 5ny7A-2o2qA:
undetectable		 5ny7A-2o2qA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 7 PHE A 880
GLY A 881
GLY A 873
GLU A 891
 None
SO4  A3014 (-3.4A)
None
None
 0.80A 5ybbB-2o2qA:
undetectable		 5ybbB-2o2qA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 8 ILE A 800
LYS A 802
ASP A 796
HIS A 797
 None
 0.96A 6ag0C-2o2qA:
undetectable		 6ag0C-2o2qA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		5 / 12 LEU A 637
THR A 584
ILE A 569
ALA A 456
LEU A 580
 None
 1.22A 6ie8A-2o2qA:
undetectable		 6ie8A-2o2qA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 6 ASP A 819
ARG A 826
ASP A 796
GLU A 795
 None
 1.46A 6mn5D-2o2qA:
undetectable		 6mn5D-2o2qA:
11.36