SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o2t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 2o2t MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 182
GLY A 146
GLY A 147
ALA A 176
LEU A 140
 None
 1.00A 1bx4A-2o2tA:
undetectable		 1bx4A-2o2tA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 2o2t MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		4 / 7 PHE A 122
ALA A 195
LEU A 189
MET A 129
 None
 0.79A 1hk2A-2o2tA:
undetectable		 1hk2A-2o2tA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2o2t MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		5 / 12 GLN A 217
ALA A 212
PHE A 150
GLY A 193
LEU A 196
 None
 1.33A 3aodC-2o2tA:
undetectable		 3aodC-2o2tA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 2o2t MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		4 / 5 TYR A 228
GLN A 187
ILE A 191
PHE A 166
 None
 1.21A 3ls4L-2o2tA:
undetectable		 3ls4L-2o2tA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 2o2t MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		3 / 3 GLY A 146
GLY A 147
GLN A 171
 None
 0.45A 5imsA-2o2tA:
undetectable		 5imsA-2o2tA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 2o2t MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 182
GLY A 146
GLY A 147
ALA A 176
LEU A 140
 None
 0.98A 5kb5A-2o2tA:
undetectable		 5kb5A-2o2tA:
17.25