SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o2v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 2o2v MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 3
(Homo
sapiens) 		4 / 6 ARG B  56
PHE B  49
ILE B  58
PHE B  60
 None
 1.12A 2qeiA-2o2vB:
undetectable		 2qeiA-2o2vB:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 2o2v DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 5
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 3
(Homo
sapiens;
Homo
sapiens) 		3 / 3 SER B 115
GLU B  50
ASP A  66
 None
 0.77A 2zthA-2o2vB:
undetectable		 2zthA-2o2vB:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2o2v DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 5
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 3
(Homo
sapiens;
Homo
sapiens) 		3 / 3 SER B 115
GLU B  50
ASP A  66
 None
 0.75A 3bwmA-2o2vB:
undetectable		 3bwmA-2o2vB:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 2o2v DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 5
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 3
(Homo
sapiens;
Homo
sapiens) 		3 / 3 SER B 115
GLU B  50
ASP A  66
 None
 0.67A 3bwyA-2o2vB:
undetectable		 3bwyA-2o2vB:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2o2v DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 5
(Homo
sapiens) 		5 / 8 ILE A  19
ASP A  30
ILE A  21
GLN A  50
GLY A  49
 None
 1.17A 4ac9C-2o2vA:
undetectable		 4ac9C-2o2vA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2o2v DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 5
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 3
(Homo
sapiens;
Homo
sapiens) 		3 / 3 SER B 115
GLU B  50
ASP A  66
 None
 0.76A 4xudA-2o2vB:
undetectable		 4xudA-2o2vB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2o2v DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 5
(Homo
sapiens) 		5 / 12 LEU A 102
ILE A 104
ILE A  48
VAL A  44
LEU A  82
 None
 0.78A 4y0sA-2o2vA:
undetectable		 4y0sA-2o2vA:
20.95