SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o3a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 2o3a UPF0106 PROTEIN
AF_0751
(Archaeoglobus
fulgidus) 		8 / 11 LEU A  79
MET A  81
VAL A 103
GLY A 104
ILE A 122
HIS A 127
GLU A 129
ALA A 132
 None
 0.47A 2yy8A-2o3aA:
25.4
2yy8B-2o3aA:
25.4		 2yy8A-2o3aA:
56.37
2yy8B-2o3aA:
56.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 2o3a UPF0106 PROTEIN
AF_0751
(Archaeoglobus
fulgidus) 		4 / 6 VAL A 130
VAL A   5
PHE A  36
GLU A 129
 None
 1.46A 3n61A-2o3aA:
undetectable
3n61B-2o3aA:
undetectable		 3n61A-2o3aA:
16.98
3n61B-2o3aA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2o3a UPF0106 PROTEIN
AF_0751
(Archaeoglobus
fulgidus) 		4 / 5 TYR A  82
ILE A  93
LEU A  90
LYS A  89
 None
 1.24A 3sueC-2o3aA:
undetectable		 3sueC-2o3aA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2o3a UPF0106 PROTEIN
AF_0751
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 101
LEU A   1
PHE A 136
LEU A  86
VAL A  77
 None
 1.15A 4eckB-2o3aA:
undetectable		 4eckB-2o3aA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2o3a UPF0106 PROTEIN
AF_0751
(Archaeoglobus
fulgidus) 		6 / 12 GLY A 142
VAL A   3
VAL A 135
ALA A 134
LEU A 137
ALA A  26
 None
 1.25A 5kpcA-2o3aA:
undetectable		 5kpcA-2o3aA:
19.04