SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o3b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2o3b NUCLEASE
(Nostoc
sp.
PCC
7120) 		4 / 4 THR A 158
LEU A 162
LEU A 169
GLN A 172
 None
 0.89A 1fbmA-2o3bA:
undetectable		 1fbmA-2o3bA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2o3b NUCLEASE
(Nostoc
sp.
PCC
7120) 		4 / 5 THR A 158
LEU A 162
LEU A 169
GLN A 172
 None
 0.85A 1fbmE-2o3bA:
undetectable		 1fbmE-2o3bA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 2o3b SUGAR-NON-SPECIFIC
NUCLEASE INHIBITOR
(Nostoc
sp.
PCC
7120) 		5 / 11 ALA B  70
LEU B  91
LEU B  19
THR B 130
VAL B 114
 None
 1.07A 1ictA-2o3bB:
undetectable
1ictC-2o3bB:
undetectable		 1ictA-2o3bB:
23.87
1ictC-2o3bB:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 2o3b NUCLEASE
SUGAR-NON-SPECIFIC
NUCLEASE INHIBITOR
(Nostoc
sp.
PCC
7120;
Nostoc
sp.
PCC
7120) 		3 / 3 ASP A 130
GLU B  24
ARG A  98
 None
MG  A 303 ( 4.0A)
None
 0.78A 1wopA-2o3bA:
undetectable		 1wopA-2o3bA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 2o3b NUCLEASE
(Nostoc
sp.
PCC
7120) 		4 / 8 PRO A  99
THR A 111
PRO A 112
SER A 113
 None
 0.98A 2v41C-2o3bA:
undetectable
2v41D-2o3bA:
undetectable		 2v41C-2o3bA:
23.51
2v41D-2o3bA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 2o3b NUCLEASE
(Nostoc
sp.
PCC
7120) 		5 / 12 THR A  75
GLY A 123
GLN A 150
ASN A  70
LEU A  67
 None
MG  A 303 ( 4.6A)
MG  A 303 ( 4.9A)
None
None
 1.09A 3eeyA-2o3bA:
undetectable		 3eeyA-2o3bA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 2o3b NUCLEASE
(Nostoc
sp.
PCC
7120) 		5 / 12 THR A  75
GLY A 123
GLN A 150
ASN A  70
LEU A  67
 None
MG  A 303 ( 4.6A)
MG  A 303 ( 4.9A)
None
None
 1.08A 3eeyC-2o3bA:
undetectable		 3eeyC-2o3bA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 2o3b NUCLEASE
(Nostoc
sp.
PCC
7120) 		5 / 12 THR A  75
GLY A 123
GLN A 150
ASN A  70
LEU A  67
 None
MG  A 303 ( 4.6A)
MG  A 303 ( 4.9A)
None
None
 1.08A 3eeyD-2o3bA:
undetectable		 3eeyD-2o3bA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 2o3b NUCLEASE
(Nostoc
sp.
PCC
7120) 		5 / 12 THR A  75
GLY A 123
GLN A 150
ASN A  70
LEU A  67
 None
MG  A 303 ( 4.6A)
MG  A 303 ( 4.9A)
None
None
 1.17A 3eeyH-2o3bA:
undetectable		 3eeyH-2o3bA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 2o3b NUCLEASE
(Nostoc
sp.
PCC
7120) 		3 / 3 ASN A 157
ASN A 155
GLU A 163
 None
MG  A 303 (-2.8A)
MG  A 303 ( 3.9A)
 0.94A 3kpdC-2o3bA:
undetectable		 3kpdC-2o3bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2o3b NUCLEASE
(Nostoc
sp.
PCC
7120) 		4 / 7 LEU A 103
SER A  72
ASN A  71
THR A 195
 None
 1.03A 3lm8A-2o3bA:
undetectable
3lm8C-2o3bA:
undetectable		 3lm8A-2o3bA:
21.59
3lm8C-2o3bA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2o3b SUGAR-NON-SPECIFIC
NUCLEASE INHIBITOR
(Nostoc
sp.
PCC
7120) 		5 / 11 LEU B  19
PHE B  29
SER B  16
ALA B  70
THR B  71
 None
 0.88A 3mdtB-2o3bB:
undetectable		 3mdtB-2o3bB:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 2o3b NUCLEASE
(Nostoc
sp.
PCC
7120) 		3 / 3 PRO A 152
THR A 151
LEU A 234
 None
 0.70A 3ttrA-2o3bA:
undetectable		 3ttrA-2o3bA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2o3b NUCLEASE
SUGAR-NON-SPECIFIC
NUCLEASE INHIBITOR
(Nostoc
sp.
PCC
7120) 		4 / 7 ASP A 153
ASN A 157
GLU B 111
GLU A 233
 None
 1.02A 4feuB-2o3bA:
undetectable		 4feuB-2o3bA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2o3b NUCLEASE
SUGAR-NON-SPECIFIC
NUCLEASE INHIBITOR
(Nostoc
sp.
PCC
7120) 		4 / 7 ASP A 153
ASN A 157
GLU B 111
GLU A 233
 None
 1.11A 4fevB-2o3bA:
undetectable		 4fevB-2o3bA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2o3b NUCLEASE
SUGAR-NON-SPECIFIC
NUCLEASE INHIBITOR
(Nostoc
sp.
PCC
7120) 		4 / 7 ASP A 153
ASN A 157
GLU B 111
GLU A 233
 None
 1.11A 4fewB-2o3bA:
undetectable		 4fewB-2o3bA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2o3b NUCLEASE
SUGAR-NON-SPECIFIC
NUCLEASE INHIBITOR
(Nostoc
sp.
PCC
7120) 		4 / 7 ASP A 153
ASN A 157
GLU B 111
GLU A 233
 None
 1.20A 4fexB-2o3bA:
undetectable		 4fexB-2o3bA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2o3b NUCLEASE
SUGAR-NON-SPECIFIC
NUCLEASE INHIBITOR
(Nostoc
sp.
PCC
7120) 		4 / 8 ASP A 153
ASN A 157
GLU B 111
GLU A 233
 None
 1.08A 4gkhD-2o3bA:
undetectable		 4gkhD-2o3bA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA303_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 2o3b NUCLEASE
SUGAR-NON-SPECIFIC
NUCLEASE INHIBITOR
(Nostoc
sp.
PCC
7120;
Nostoc
sp.
PCC
7120) 		4 / 4 LEU B 112
VAL B 110
GLU B 111
ARG A 156
 None
MES  A 901 (-4.6A)
None
MES  A 901 (-4.8A)
 1.49A 4ww7A-2o3bB:
0.0		 4ww7A-2o3bB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2o3b NUCLEASE
(Nostoc
sp.
PCC
7120) 		5 / 12 ALA A 140
TYR A 254
GLY A 184
THR A 195
MET A 148
 None
 1.03A 5jlcA-2o3bA:
undetectable		 5jlcA-2o3bA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2o3b NUCLEASE
SUGAR-NON-SPECIFIC
NUCLEASE INHIBITOR
(Nostoc
sp.
PCC
7120) 		3 / 3 THR B 135
THR A 200
LEU A 234
 MG  A 303 ( 2.9A)
None
None
 0.70A 5m66D-2o3bB:
undetectable		 5m66D-2o3bB:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 2o3b NUCLEASE
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU A 248
TRP A 159
TRP A 201
ILE A 125
PRO A  45
 None
 1.04A 5og9B-2o3bA:
undetectable		 5og9B-2o3bA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 2o3b NUCLEASE
SUGAR-NON-SPECIFIC
NUCLEASE INHIBITOR
(Nostoc
sp.
PCC
7120) 		3 / 3 ARG B  69
ARG A  93
ARG A 122
 MES  A 900 (-4.4A)
None
None
 0.70A 5vcgA-2o3bB:
undetectable		 5vcgA-2o3bB:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 2o3b NUCLEASE
SUGAR-NON-SPECIFIC
NUCLEASE INHIBITOR
(Nostoc
sp.
PCC
7120) 		5 / 12 THR A  75
PRO A  99
VAL B 110
GLU A 163
GLY A 160
 None
None
MES  A 901 (-4.6A)
MG  A 303 ( 3.9A)
MES  A 901 (-3.4A)
 1.47A 6gngB-2o3bA:
undetectable		 6gngB-2o3bA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2o3b NUCLEASE
SUGAR-NON-SPECIFIC
NUCLEASE INHIBITOR
(Nostoc
sp.
PCC
7120;
Nostoc
sp.
PCC
7120) 		3 / 3 THR A 200
GLU B  24
ASN A 154
 None
MG  A 303 ( 4.0A)
None
 0.88A 6nj9K-2o3bA:
undetectable		 6nj9K-2o3bA:
18.97