SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o3c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 2o3c APEX NUCLEASE 1
(Danio
rerio) 		4 / 7 ARG A 149
ASP A 182
TYR A 177
ARG A 174
 None
 1.46A 1ceaB-2o3cA:
undetectable		 1ceaB-2o3cA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2o3c APEX NUCLEASE 1
(Danio
rerio) 		5 / 12 ASN A  61
GLY A 202
ASP A 300
ASN A 167
ARG A 149
 None
 1.21A 1q8jB-2o3cA:
2.6		 1q8jB-2o3cA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 2o3c APEX NUCLEASE 1
(Danio
rerio) 		5 / 11 PHE A 155
LEU A 160
VAL A 199
LEU A 279
LEU A 306
 None
 1.15A 1rlbF-2o3cA:
undetectable		 1rlbF-2o3cA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2o3c APEX NUCLEASE 1
(Danio
rerio) 		3 / 3 ARG A 246
ASN A 205
THR A 257
 None
 0.74A 2q63A-2o3cA:
undetectable		 2q63A-2o3cA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_B_LNRB200_1
(D7R4 PROTEIN)		 2o3c APEX NUCLEASE 1
(Danio
rerio) 		5 / 10 GLU A  80
ARG A 293
ASP A 289
GLU A  43
ASP A  40
 None
 1.23A 2qeoB-2o3cA:
undetectable		 2qeoB-2o3cA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2o3c APEX NUCLEASE 1
(Danio
rerio) 		4 / 7 THR A 136
VAL A 150
THR A 152
VAL A 161
 None
 0.44A 3em0B-2o3cA:
undetectable		 3em0B-2o3cA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2o3c APEX NUCLEASE 1
(Danio
rerio) 		5 / 12 LEU A  65
GLY A 114
GLY A 123
ILE A 151
ALA A  93
 None
 0.97A 4a6dA-2o3cA:
undetectable		 4a6dA-2o3cA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2o3c APEX NUCLEASE 1
(Danio
rerio) 		5 / 12 LEU A  65
GLY A 114
GLY A 123
ILE A 151
ALA A  93
 None
 0.98A 4a6eA-2o3cA:
undetectable		 4a6eA-2o3cA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2o3c APEX NUCLEASE 1
(Danio
rerio) 		5 / 12 ALA A 194
GLY A 240
LEU A 237
LEU A 236
GLU A 247
 None
 1.04A 4lg1A-2o3cA:
3.4		 4lg1A-2o3cA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2o3c APEX NUCLEASE 1
(Danio
rerio) 		5 / 12 ALA A 194
GLY A 240
LEU A 237
LEU A 236
GLU A 247
 None
 1.04A 4lg1B-2o3cA:
3.6		 4lg1B-2o3cA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 2o3c APEX NUCLEASE 1
(Danio
rerio) 		4 / 6 ASP A 212
ASP A 243
SER A 290
ALA A 255
 None
 1.23A 4nedA-2o3cA:
undetectable		 4nedA-2o3cA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 2o3c APEX NUCLEASE 1
(Danio
rerio) 		5 / 12 TYR A 188
ASN A 134
LEU A 192
LEU A 189
ALA A 163
 None
 1.40A 4rtbA-2o3cA:
undetectable		 4rtbA-2o3cA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2o3c APEX NUCLEASE 1
(Danio
rerio) 		4 / 5 TYR A 107
ILE A 101
PRO A 132
THR A 162
 None
 1.26A 4ze1A-2o3cA:
undetectable		 4ze1A-2o3cA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2o3c APEX NUCLEASE 1
(Danio
rerio) 		3 / 3 ASP A 203
ASN A  61
ASP A  63
 None
None
PB  A 402 (-3.3A)
 0.83A 5vopA-2o3cA:
undetectable		 5vopA-2o3cA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2o3c APEX NUCLEASE 1
(Danio
rerio) 		3 / 3 ASP A 203
ASN A  61
ASP A  63
 None
None
PB  A 402 (-3.3A)
 0.80A 5vopB-2o3cA:
2.4		 5vopB-2o3cA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2o3c APEX NUCLEASE 1
(Danio
rerio) 		4 / 6 VAL A  69
LEU A  65
LEU A  87
MET A 104
 None
 1.03A 6f6sA-2o3cA:
undetectable
6f6sB-2o3cA:
undetectable		 6f6sA-2o3cA:
15.06
6f6sB-2o3cA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2o3c APEX NUCLEASE 1
(Danio
rerio) 		4 / 6 ASP A 275
TYR A 164
GLU A  89
ASP A  63
 None
None
None
PB  A 402 (-3.3A)
 1.36A 6mn5A-2o3cA:
undetectable		 6mn5A-2o3cA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2o3c APEX NUCLEASE 1
(Danio
rerio) 		4 / 6 ASP A 275
TYR A 164
GLU A  89
ASP A  63
 None
None
None
PB  A 402 (-3.3A)
 1.45A 6mn5C-2o3cA:
undetectable		 6mn5C-2o3cA:
16.19