SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o3e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		3 / 3 GLU A 510
HIS A 474
ASP A 467
 None
ZN  A 679 (-3.4A)
None
 0.88A 1i9gA-2o3eA:
undetectable		 1i9gA-2o3eA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		6 / 12 THR A 471
HIS A 474
GLU A 475
HIS A 478
GLU A 503
TYR A 613
 None
ZN  A 679 (-3.4A)
ZN  A 679 ( 4.5A)
ZN  A 679 (-3.3A)
ZN  A 679 (-2.1A)
None
 1.13A 1j36A-2o3eA:
18.9		 1j36A-2o3eA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		6 / 12 THR A 471
HIS A 474
GLU A 475
HIS A 478
GLU A 503
TYR A 613
 None
ZN  A 679 (-3.4A)
ZN  A 679 ( 4.5A)
ZN  A 679 (-3.3A)
ZN  A 679 (-2.1A)
None
 1.13A 1j36B-2o3eA:
18.9		 1j36B-2o3eA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		5 / 11 HIS A 474
GLU A 475
HIS A 478
GLU A 503
TYR A 613
 ZN  A 679 (-3.4A)
ZN  A 679 ( 4.5A)
ZN  A 679 (-3.3A)
ZN  A 679 (-2.1A)
None
 1.15A 1j37A-2o3eA:
18.8		 1j37A-2o3eA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		5 / 11 HIS A 474
GLU A 475
HIS A 478
GLU A 503
TYR A 613
 ZN  A 679 (-3.4A)
ZN  A 679 ( 4.5A)
ZN  A 679 (-3.3A)
ZN  A 679 (-2.1A)
None
 1.15A 1j37B-2o3eA:
18.8		 1j37B-2o3eA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		3 / 3 PHE A 473
LEU A 522
LEU A 519
 None
 0.66A 1mx1E-2o3eA:
undetectable		 1mx1E-2o3eA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		5 / 12 HIS A 474
GLU A 475
HIS A 478
GLU A 503
TYR A 613
 ZN  A 679 (-3.4A)
ZN  A 679 ( 4.5A)
ZN  A 679 (-3.3A)
ZN  A 679 (-2.1A)
None
 1.15A 1o86A-2o3eA:
19.0		 1o86A-2o3eA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U65_A_CP0A1000_1
(ACETYLCHOLINESTERASE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		5 / 11 TYR A 642
GLU A 503
ASP A 402
TYR A 374
HIS A 478
 None
ZN  A 679 (-2.1A)
None
None
ZN  A 679 (-3.3A)
 1.38A 1u65A-2o3eA:
1.5		 1u65A-2o3eA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 7 LEU A 257
GLN A 258
LEU A 602
PHE A 599
 None
 0.95A 1v55P-2o3eA:
5.0
1v55W-2o3eA:
undetectable		 1v55P-2o3eA:
17.94
1v55W-2o3eA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 8 GLU A 503
HIS A 474
HIS A 478
GLU A 475
 ZN  A 679 (-2.1A)
ZN  A 679 (-3.4A)
ZN  A 679 (-3.3A)
ZN  A 679 ( 4.5A)
 0.81A 1v7zA-2o3eA:
undetectable		 1v7zA-2o3eA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 8 GLU A 503
HIS A 474
HIS A 478
GLU A 475
 ZN  A 679 (-2.1A)
ZN  A 679 (-3.4A)
ZN  A 679 (-3.3A)
ZN  A 679 ( 4.5A)
 0.81A 1v7zB-2o3eA:
undetectable		 1v7zB-2o3eA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 8 GLU A 503
HIS A 474
HIS A 478
GLU A 475
 ZN  A 679 (-2.1A)
ZN  A 679 (-3.4A)
ZN  A 679 (-3.3A)
ZN  A 679 ( 4.5A)
 0.81A 1v7zC-2o3eA:
undetectable		 1v7zC-2o3eA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 8 GLU A 503
HIS A 474
HIS A 478
GLU A 475
 ZN  A 679 (-2.1A)
ZN  A 679 (-3.4A)
ZN  A 679 (-3.3A)
ZN  A 679 ( 4.5A)
 0.84A 1v7zD-2o3eA:
undetectable		 1v7zD-2o3eA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 8 GLU A 503
HIS A 474
HIS A 478
GLU A 475
 ZN  A 679 (-2.1A)
ZN  A 679 (-3.4A)
ZN  A 679 (-3.3A)
ZN  A 679 ( 4.5A)
 0.84A 1v7zE-2o3eA:
undetectable		 1v7zE-2o3eA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 8 GLU A 503
HIS A 474
HIS A 478
GLU A 475
 ZN  A 679 (-2.1A)
ZN  A 679 (-3.4A)
ZN  A 679 (-3.3A)
ZN  A 679 ( 4.5A)
 0.82A 1v7zF-2o3eA:
undetectable		 1v7zF-2o3eA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		3 / 3 LEU A 647
LEU A 645
MET A 623
 None
 0.81A 1ya3B-2o3eA:
undetectable		 1ya3B-2o3eA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		6 / 12 ALA A 426
HIS A 474
GLU A 475
HIS A 478
GLU A 503
TYR A 613
 None
ZN  A 679 (-3.4A)
ZN  A 679 ( 4.5A)
ZN  A 679 (-3.3A)
ZN  A 679 (-2.1A)
None
 1.02A 2c6nA-2o3eA:
18.4		 2c6nA-2o3eA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		5 / 12 HIS A 474
GLU A 475
HIS A 478
GLU A 503
TYR A 613
 ZN  A 679 (-3.4A)
ZN  A 679 ( 4.5A)
ZN  A 679 (-3.3A)
ZN  A 679 (-2.1A)
None
 1.14A 2c6nB-2o3eA:
18.8		 2c6nB-2o3eA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 7 LEU A 257
GLN A 258
LEU A 602
PHE A 599
 None
 0.86A 2dysP-2o3eA:
5.0
2dysW-2o3eA:
undetectable		 2dysP-2o3eA:
17.94
2dysW-2o3eA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 7 LEU A 257
GLN A 258
LEU A 602
PHE A 599
 None
 0.89A 2eijP-2o3eA:
5.0
2eijW-2o3eA:
undetectable		 2eijP-2o3eA:
17.94
2eijW-2o3eA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 8 LEU A 257
GLN A 258
LEU A 602
PHE A 599
 None
 0.89A 2eikP-2o3eA:
5.0
2eikW-2o3eA:
undetectable		 2eikP-2o3eA:
17.94
2eikW-2o3eA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 8 LEU A 257
GLN A 258
LEU A 602
PHE A 599
 None
 0.87A 2eilP-2o3eA:
5.0
2eilW-2o3eA:
undetectable		 2eilP-2o3eA:
17.94
2eilW-2o3eA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 6 LEU A 257
GLN A 258
LEU A 602
PHE A 599
 None
 0.92A 2einP-2o3eA:
5.0
2einW-2o3eA:
undetectable		 2einP-2o3eA:
17.94
2einW-2o3eA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 8 THR A 471
HIS A 474
GLU A 475
HIS A 478
 None
ZN  A 679 (-3.4A)
ZN  A 679 ( 4.5A)
ZN  A 679 (-3.3A)
 0.38A 2jihB-2o3eA:
undetectable		 2jihB-2o3eA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PK4_A_ACAA100_1
(HUMAN PLASMINOGEN
KRINGLE 4)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 7 LYS A 318
ASP A 330
ARG A 238
TRP A 336
 None
 1.30A 2pk4A-2o3eA:
undetectable		 2pk4A-2o3eA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 7 ILE A  72
TYR A  76
PHE A 109
ASP A 110
 None
 0.89A 2qebA-2o3eA:
undetectable		 2qebA-2o3eA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 7 ILE A  72
TYR A  76
PHE A 109
ASP A 110
 None
 0.90A 2qebB-2o3eA:
undetectable		 2qebB-2o3eA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		5 / 12 PHE A  85
VAL A 395
ALA A 448
ASP A 415
ARG A 419
 None
 1.29A 2qm9A-2o3eA:
undetectable		 2qm9A-2o3eA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		5 / 11 HIS A 474
GLU A 475
HIS A 478
GLU A 503
TYR A 613
 ZN  A 679 (-3.4A)
ZN  A 679 ( 4.5A)
ZN  A 679 (-3.3A)
ZN  A 679 (-2.1A)
None
 1.13A 2x8zA-2o3eA:
19.9		 2x8zA-2o3eA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		5 / 12 HIS A 474
GLU A 475
HIS A 478
GLU A 503
TYR A 613
 ZN  A 679 (-3.4A)
ZN  A 679 ( 4.5A)
ZN  A 679 (-3.3A)
ZN  A 679 (-2.1A)
None
 1.13A 2x91A-2o3eA:
18.5		 2x91A-2o3eA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		3 / 3 GLU A 112
ASP A 110
TYR A  76
 None
 0.63A 2yvlB-2o3eA:
undetectable		 2yvlB-2o3eA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 8 GLU A 503
HIS A 474
HIS A 478
GLU A 475
 ZN  A 679 (-2.1A)
ZN  A 679 (-3.4A)
ZN  A 679 (-3.3A)
ZN  A 679 ( 4.5A)
 0.80A 3a6jA-2o3eA:
undetectable		 3a6jA-2o3eA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 7 GLU A 503
HIS A 474
HIS A 478
GLU A 475
 ZN  A 679 (-2.1A)
ZN  A 679 (-3.4A)
ZN  A 679 (-3.3A)
ZN  A 679 ( 4.5A)
 0.77A 3a6jB-2o3eA:
undetectable		 3a6jB-2o3eA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 8 GLU A 503
HIS A 474
HIS A 478
GLU A 475
 ZN  A 679 (-2.1A)
ZN  A 679 (-3.4A)
ZN  A 679 (-3.3A)
ZN  A 679 ( 4.5A)
 0.78A 3a6jC-2o3eA:
undetectable		 3a6jC-2o3eA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 8 GLU A 503
HIS A 474
HIS A 478
GLU A 475
 ZN  A 679 (-2.1A)
ZN  A 679 (-3.4A)
ZN  A 679 (-3.3A)
ZN  A 679 ( 4.5A)
 0.80A 3a6jE-2o3eA:
undetectable		 3a6jE-2o3eA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 8 GLU A 503
HIS A 474
HIS A 478
GLU A 475
 ZN  A 679 (-2.1A)
ZN  A 679 (-3.4A)
ZN  A 679 (-3.3A)
ZN  A 679 ( 4.5A)
 0.77A 3a6jF-2o3eA:
undetectable		 3a6jF-2o3eA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 7 LEU A 257
GLN A 258
LEU A 602
PHE A 599
 None
 0.79A 3ag2P-2o3eA:
5.0
3ag2W-2o3eA:
undetectable		 3ag2P-2o3eA:
17.94
3ag2W-2o3eA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		5 / 12 LEU A 614
GLU A 617
LEU A 678
LEU A 303
GLY A 549
 None
 1.28A 3g1uA-2o3eA:
undetectable		 3g1uA-2o3eA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 8 SER A 616
ASP A 622
ASP A 500
ASP A 654
 None
 1.16A 3havA-2o3eA:
2.7		 3havA-2o3eA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		3 / 3 GLY A 586
ILE A 556
VAL A 557
 None
 0.30A 3nv6A-2o3eA:
undetectable		 3nv6A-2o3eA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		3 / 3 TYR A  49
ASP A 110
ASP A  84
 None
 0.90A 3ou6B-2o3eA:
undetectable		 3ou6B-2o3eA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 5 PHE A 327
ILE A 314
LEU A 317
LYS A 318
 None
 0.86A 3sueC-2o3eA:
undetectable		 3sueC-2o3eA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 5 LEU A 449
ALA A 427
PHE A 429
ASN A 452
 None
 1.44A 3uq6A-2o3eA:
undetectable		 3uq6A-2o3eA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 4 LEU A 449
ALA A 427
PHE A 429
ASN A 452
 None
 1.48A 3vaqA-2o3eA:
undetectable		 3vaqA-2o3eA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 7 LEU A 257
GLN A 258
LEU A 602
PHE A 599
 None
 0.85A 3x2qP-2o3eA:
5.0
3x2qW-2o3eA:
undetectable		 3x2qP-2o3eA:
17.94
3x2qW-2o3eA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		5 / 11 HIS A 474
GLU A 475
HIS A 478
GLU A 503
TYR A 613
 ZN  A 679 (-3.4A)
ZN  A 679 ( 4.5A)
ZN  A 679 (-3.3A)
ZN  A 679 (-2.1A)
None
 1.16A 4c2pA-2o3eA:
19.2		 4c2pA-2o3eA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 6 HIS A 478
HIS A 474
TYR A 613
GLU A 503
 ZN  A 679 (-3.3A)
ZN  A 679 (-3.4A)
None
ZN  A 679 (-2.1A)
 0.82A 4pahA-2o3eA:
undetectable		 4pahA-2o3eA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		5 / 12 HIS A 474
GLU A 475
HIS A 478
GLU A 503
TYR A 613
 ZN  A 679 (-3.4A)
ZN  A 679 ( 4.5A)
ZN  A 679 (-3.3A)
ZN  A 679 (-2.1A)
None
 1.03A 4r7lA-2o3eA:
5.9		 4r7lA-2o3eA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		3 / 3 ASP A 330
ARG A 238
PRO A 235
 None
 0.98A 4wanC-2o3eA:
undetectable		 4wanC-2o3eA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 6 CYH A 130
LEU A 143
HIS A 125
LEU A 126
 None
 0.92A 5hpuC-2o3eA:
undetectable
5hpuD-2o3eA:
undetectable		 5hpuC-2o3eA:
3.38
5hpuD-2o3eA:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		5 / 12 LEU A 380
PHE A 382
LEU A 370
TYR A 642
GLY A 477
 None
 1.18A 5i8fA-2o3eA:
undetectable		 5i8fA-2o3eA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		5 / 12 LEU A 397
VAL A 395
LEU A 449
VAL A 479
GLY A 430
 None
 1.40A 5i8fA-2o3eA:
undetectable		 5i8fA-2o3eA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LI8_A_KKKA502_1
(PUTATIVE CYTOCHROME
P450 126)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		5 / 12 THR A 593
ASN A 184
ALA A 603
ARG A 248
ASN A 594
 None
 1.40A 5li8A-2o3eA:
0.0		 5li8A-2o3eA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 5 THR A 275
HIS A 276
ALA A 277
ASP A 278
 None
 1.42A 5mfxA-2o3eA:
undetectable		 5mfxA-2o3eA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 4 HIS A 478
HIS A 474
TYR A 613
GLU A 503
 ZN  A 679 (-3.3A)
ZN  A 679 (-3.4A)
None
ZN  A 679 (-2.1A)
 0.80A 5pahA-2o3eA:
undetectable		 5pahA-2o3eA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		4 / 9 HIS A 425
LEU A 509
VAL A 504
SER A 620
 None
 0.88A 6c2mD-2o3eA:
undetectable		 6c2mD-2o3eA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		3 / 3 VAL A 292
ALA A 286
GLN A 563
 None
 0.67A 6gb9A-2o3eA:
undetectable		 6gb9A-2o3eA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2o3e NEUROLYSIN
(Rattus
norvegicus) 		5 / 6 PRO A 505
HIS A 478
HIS A 474
TYR A 613
GLU A 503
 None
ZN  A 679 (-3.3A)
ZN  A 679 (-3.4A)
None
ZN  A 679 (-2.1A)
 1.27A 6pahA-2o3eA:
undetectable		 6pahA-2o3eA:
20.35