SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o3j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		4 / 7 ALA A 198
GLU A 201
LEU A 202
VAL A 132
 None
 0.73A 1hk2A-2o3jA:
undetectable		 1hk2A-2o3jA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		4 / 6 LEU A 291
ALA A 304
LEU A 294
SER A 297
 None
 1.07A 1ictB-2o3jA:
undetectable		 1ictB-2o3jA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		5 / 11 SER A 276
VAL A 277
GLY A 278
GLY A 446
PHE A 321
 None
 1.44A 1iolA-2o3jA:
5.9		 1iolA-2o3jA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		4 / 8 TRP A 221
GLY A 188
GLU A 133
SER A 165
 GOL  A 905 (-3.8A)
None
None
None
 0.93A 1maaD-2o3jA:
undetectable		 1maaD-2o3jA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		5 / 12 LEU A 371
MET A 365
HIS A 363
ILE A 358
ILE A 340
 None
 1.47A 1ot7B-2o3jA:
undetectable		 1ot7B-2o3jA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		4 / 5 LEU A 291
ALA A 304
LEU A 294
SER A 297
 None
 1.02A 1tt6B-2o3jA:
undetectable		 1tt6B-2o3jA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		4 / 5 ASP A 386
GLY A 281
ALA A 357
ILE A 358
 None
 0.93A 2aofA-2o3jA:
undetectable		 2aofA-2o3jA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		4 / 5 ALA A  45
ILE A  47
ASN A  43
ASP A  41
 None
 1.05A 2h4jA-2o3jA:
4.1		 2h4jA-2o3jA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		4 / 5 ALA A 142
TRP A 221
LEU A 225
ALA A 141
 None
GOL  A 905 (-3.8A)
None
None
 1.33A 2jstA-2o3jA:
undetectable
2jstB-2o3jA:
undetectable		 2jstA-2o3jA:
10.33
2jstB-2o3jA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		4 / 5 PRO A  60
ALA A 175
ASP A  63
ASP A  53
 None
 1.14A 2nyuB-2o3jA:
5.0		 2nyuB-2o3jA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		5 / 12 ASN A 315
ASP A 445
ILE A 449
PHE A 321
ALA A 322
 None
 1.47A 2qmjA-2o3jA:
undetectable		 2qmjA-2o3jA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		4 / 6 LEU A 291
ALA A 304
LEU A 294
SER A 297
 None
 1.06A 3cfqA-2o3jA:
undetectable		 3cfqA-2o3jA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 325
HIS A 414
ALA A 369
LEU A 364
LEU A 419
 None
 1.10A 3ozwB-2o3jA:
4.1		 3ozwB-2o3jA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		3 / 4 SER A 282
GLY A  18
GLU A  49
 None
 0.52A 3raeA-2o3jA:
undetectable
3raeC-2o3jA:
undetectable		 3raeA-2o3jA:
23.89
3raeC-2o3jA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		5 / 11 ILE A 400
VAL A 417
LEU A 419
PHE A 444
VAL A 277
 None
 1.00A 3w67A-2o3jA:
undetectable		 3w67A-2o3jA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 400
VAL A 417
LEU A 419
PHE A 444
VAL A 277
 None
 0.83A 3w68C-2o3jA:
undetectable		 3w68C-2o3jA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 400
VAL A 417
LEU A 419
PHE A 444
VAL A 277
 None
 0.81A 3w68D-2o3jA:
undetectable		 3w68D-2o3jA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		4 / 7 GLU A 249
ILE A 465
HIS A 363
PHE A 444
 None
 1.04A 4a97H-2o3jA:
undetectable		 4a97H-2o3jA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		4 / 5 GLY A 146
ILE A 148
VAL A 131
SER A 118
 None
 1.14A 4d33A-2o3jA:
undetectable		 4d33A-2o3jA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		4 / 5 GLY A 146
ILE A 148
VAL A 131
SER A 118
 None
 1.16A 4d33B-2o3jA:
undetectable		 4d33B-2o3jA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		4 / 6 LEU A 291
ALA A 304
LEU A 294
SER A 297
 None
 1.00A 4i89A-2o3jA:
undetectable		 4i89A-2o3jA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		3 / 4 SER A 282
GLY A  18
GLU A  49
 None
 0.59A 4juoA-2o3jA:
undetectable
4juoC-2o3jA:
undetectable		 4juoA-2o3jA:
23.89
4juoC-2o3jA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		4 / 6 LEU A 291
ALA A 304
LEU A 294
SER A 297
 None
 1.03A 4pwjA-2o3jA:
undetectable		 4pwjA-2o3jA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		4 / 6 LEU A 291
ALA A 304
LEU A 294
SER A 297
 None
 1.04A 5bojA-2o3jA:
undetectable		 5bojA-2o3jA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		4 / 6 GLY A  21
THR A  24
SER A  93
VAL A  20
 None
 1.11A 5ewuA-2o3jA:
4.1		 5ewuA-2o3jA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		5 / 8 ILE A 458
VAL A 373
ILE A 338
ILE A 361
ILE A 325
 None
 1.27A 5hi2A-2o3jA:
undetectable		 5hi2A-2o3jA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		4 / 8 GLN A 285
ALA A 235
GLN A 236
SER A 239
 None
 1.07A 5km8A-2o3jA:
undetectable
5km8B-2o3jA:
undetectable		 5km8A-2o3jA:
17.39
5km8B-2o3jA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		4 / 6 LEU A 291
ALA A 304
LEU A 294
SER A 297
 None
 1.03A 5l4iA-2o3jA:
undetectable		 5l4iA-2o3jA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		4 / 7 GLY A  21
PHE A  91
SER A 135
ARG A  70
 None
 1.04A 5n5dB-2o3jA:
6.7		 5n5dB-2o3jA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		4 / 8 GLU A 190
GLY A 146
GLN A 153
LEU A 149
 GOL  A 905 (-4.8A)
None
None
None
 1.01A 5sxtB-2o3jA:
undetectable		 5sxtB-2o3jA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		3 / 3 PHE A  76
ASP A  41
LYS A  46
 None
 0.88A 6awtD-2o3jA:
undetectable		 6awtD-2o3jA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		4 / 8 ASN A 166
LEU A 164
VAL A 185
ILE A 215
 None
 0.94A 6cb4A-2o3jA:
undetectable		 6cb4A-2o3jA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		5 / 12 VAL A 117
ILE A 121
VAL A 132
ILE A  90
CYH A  14
 None
 1.17A 6gsdA-2o3jA:
5.8		 6gsdA-2o3jA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2o3j UDP-GLUCOSE
6-DEHYDROGENASE
(Caenorhabditis
elegans) 		4 / 8 ILE A 465
ALA A 246
VAL A 247
ASP A 470
 None
 0.87A 6hu9a-2o3jA:
undetectable
6hu9e-2o3jA:
undetectable		 6hu9a-2o3jA:
21.62
6hu9e-2o3jA:
14.57