SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o3o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZP4_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 2o3o YYCI PROTEIN
(Bacillus
subtilis) 		5 / 9 GLN A  85
GLN A 186
GLN A 121
TYR A 184
LEU A 123
 None
 1.34A 1zp4A-2o3oA:
0.0		 1zp4A-2o3oA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 2o3o YYCI PROTEIN
(Bacillus
subtilis) 		3 / 3 GLN A  85
PHE A 105
TYR A 184
 None
 0.96A 3ucjB-2o3oA:
undetectable		 3ucjB-2o3oA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 2o3o YYCI PROTEIN
(Bacillus
subtilis) 		3 / 3 GLN A  85
PHE A 105
TYR A 184
 None
 0.99A 3ucjA-2o3oA:
undetectable		 3ucjA-2o3oA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 2o3o YYCI PROTEIN
(Bacillus
subtilis) 		5 / 12 GLY A 131
ILE A 128
MET A 167
THR A 188
LEU A 173
 None
 1.31A 5nz0A-2o3oA:
undetectable		 5nz0A-2o3oA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2o3o YYCI PROTEIN
(Bacillus
subtilis) 		5 / 12 ASP A 119
ILE A 116
ILE A 109
LEU A 175
VAL A 181
 None
 1.08A 5twjC-2o3oA:
undetectable		 5twjC-2o3oA:
20.08