SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o42'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2o42 M11L PROTEIN
(Myxoma
virus) 		4 / 4 THR A  83
LEU A  87
VAL A  90
LEU A  94
 None
 0.90A 1fbmB-2o42A:
undetectable		 1fbmB-2o42A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2o42 M11L PROTEIN
(Myxoma
virus) 		4 / 5 THR A  83
LEU A  87
VAL A  90
LEU A  94
 None
 0.80A 1fbmE-2o42A:
undetectable		 1fbmE-2o42A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 2o42 M11L PROTEIN
(Myxoma
virus) 		5 / 12 LEU A  81
LEU A  84
LEU A  87
ALA A  88
LEU A  27
 None
 1.13A 1ya3C-2o42A:
undetectable		 1ya3C-2o42A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 2o42 M11L PROTEIN
(Myxoma
virus) 		5 / 11 LEU A  68
VAL A  79
ALA A  82
LEU A  81
LEU A  72
 None
 1.24A 2c12F-2o42A:
undetectable		 2c12F-2o42A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2o42 M11L PROTEIN
(Myxoma
virus) 		4 / 7 VAL A   9
CYH A  34
TYR A  12
ILE A 123
 None
 1.36A 2xz5B-2o42A:
undetectable
2xz5E-2o42A:
undetectable		 2xz5B-2o42A:
21.86
2xz5E-2o42A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2o42 M11L PROTEIN
(Myxoma
virus) 		4 / 7 ILE A 123
VAL A   9
CYH A  34
TYR A  12
 None
 1.37A 2xz5D-2o42A:
undetectable
2xz5E-2o42A:
undetectable		 2xz5D-2o42A:
21.86
2xz5E-2o42A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 2o42 M11L PROTEIN
(Myxoma
virus) 		5 / 9 LEU A   5
SER A   3
THR A  22
ASP A  11
TYR A  10
 None
 1.39A 4drhE-2o42A:
0.0		 4drhE-2o42A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 2o42 M11L PROTEIN
(Myxoma
virus) 		5 / 10 LEU A   5
SER A   3
THR A  22
ASP A  11
TYR A  10
 None
 1.26A 4driB-2o42A:
0.0		 4driB-2o42A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 2o42 M11L PROTEIN
(Myxoma
virus) 		5 / 8 LEU A   5
SER A   3
THR A  22
ASP A  11
TYR A  10
 None
 1.38A 4drjB-2o42A:
undetectable		 4drjB-2o42A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2o42 M11L PROTEIN
(Myxoma
virus) 		5 / 12 LEU A  81
LEU A  84
LEU A  87
ALA A  88
LEU A  27
 None
 1.12A 4ltwA-2o42A:
undetectable		 4ltwA-2o42A:
20.41