SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o49'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 2o49 DNA-BINDING PROTEIN
SATB1
(Homo
sapiens) 		5 / 12 ASP A 381
GLU A 382
ARG A 440
MET A 429
ILE A 375
 None
 1.18A 1s14A-2o49A:
undetectable		 1s14A-2o49A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 2o49 DNA-BINDING PROTEIN
SATB1
(Homo
sapiens) 		5 / 12 ASP A 381
GLU A 382
ARG A 440
MET A 429
ILE A 375
 None
 1.19A 1s14B-2o49A:
undetectable		 1s14B-2o49A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 2o49 DNA-BINDING PROTEIN
SATB1
(Homo
sapiens) 		5 / 12 LEU A 405
TYR A 376
ALA A 397
PHE A 393
LEU A 433
 None
 1.19A 3gwuA-2o49A:
undetectable		 3gwuA-2o49A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 2o49 DNA-BINDING PROTEIN
SATB1
(Homo
sapiens) 		5 / 11 ASP A 381
GLU A 382
ARG A 440
MET A 429
ILE A 375
 None
 1.10A 4urnC-2o49A:
undetectable		 4urnC-2o49A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 2o49 DNA-BINDING PROTEIN
SATB1
(Homo
sapiens) 		4 / 4 ILE A 443
ARG A 385
TYR A 444
GLU A 382
 None
 1.28A 4zzbD-2o49A:
undetectable		 4zzbD-2o49A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 2o49 DNA-BINDING PROTEIN
SATB1
(Homo
sapiens) 		4 / 5 ILE A 443
ARG A 385
TYR A 444
GLU A 382
 None
 1.25A 4zzcE-2o49A:
undetectable		 4zzcE-2o49A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 2o49 DNA-BINDING PROTEIN
SATB1
(Homo
sapiens) 		3 / 3 ASP A 441
ARG A 440
TYR A 444
 None
 1.05A 5a7mB-2o49A:
undetectable		 5a7mB-2o49A:
8.30