SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o4c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 4 HIS A  71
LEU A  54
LEU A  35
LEU A  25
 None
 1.19A 1a4lD-2o4cA:
undetectable		 1a4lD-2o4cA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 139
TRP A 140
HIS A 174
VAL A 170
 None
 0.91A 1dbbH-2o4cA:
undetectable
1dbbL-2o4cA:
undetectable		 1dbbH-2o4cA:
20.99
1dbbL-2o4cA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 10 VAL A 204
LEU A 203
LEU A 164
GLY A 120
LEU A 131
 None
 1.02A 1pxxA-2o4cA:
undetectable		 1pxxA-2o4cA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 204
LEU A 203
LEU A 164
GLY A 120
LEU A 131
 None
 1.03A 1pxxC-2o4cA:
undetectable		 1pxxC-2o4cA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 GLU A  48
THR A  47
LEU A  35
 None
 0.69A 1v8bC-2o4cA:
9.5		 1v8bC-2o4cA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 318
GLY A 101
VAL A 134
VAL A  95
GLY A  94
 None
 0.87A 2qe6A-2o4cA:
undetectable		 2qe6A-2o4cA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  82
ILE A   9
LEU A  35
THR A  47
LEU A  72
 None
 1.06A 2qo5A-2o4cA:
undetectable		 2qo5A-2o4cA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  82
ILE A  30
LEU A  35
HIS A  71
LEU A  72
 None
 1.13A 2qo5A-2o4cA:
undetectable		 2qo5A-2o4cA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 203
ASP A 169
LEU A 188
HIS A 174
 None
 1.04A 2qxsA-2o4cA:
undetectable		 2qxsA-2o4cA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 203
ASP A 169
LEU A 188
HIS A 174
 None
 1.06A 2qxsB-2o4cA:
undetectable		 2qxsB-2o4cA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 ASN A 205
LEU A 173
SER A 207
THR A 175
 None
None
NAD  A1002 (-4.7A)
NAD  A1002 (-4.3A)
 1.17A 2uz2A-2o4cA:
undetectable		 2uz2A-2o4cA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 ASN A 214
GLY A 209
ILE A 250
SER A 207
 None
None
None
NAD  A1002 (-4.7A)
 0.89A 2yoeB-2o4cA:
undetectable
2yoeC-2o4cA:
undetectable		 2yoeB-2o4cA:
21.13
2yoeC-2o4cA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 9 VAL A  96
VAL A  95
GLY A  94
THR A 356
GLY A 376
 None
 1.49A 3bjwG-2o4cA:
undetectable		 3bjwG-2o4cA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 173
ILE A 171
LEU A 161
ARG A 193
ASP A 190
 None
 1.44A 4b9zA-2o4cA:
undetectable		 4b9zA-2o4cA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1Q_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  42
TYR A 274
TYR A 271
PHE A  15
PRO A  10
 None
 1.18A 4g1qA-2o4cA:
undetectable		 4g1qA-2o4cA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ID5_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  42
TYR A 274
TYR A 271
PHE A  15
PRO A  10
 None
 1.22A 4id5A-2o4cA:
undetectable		 4id5A-2o4cA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFV_A_T27A601_1
(EXORIBONUCLEASE H,
P66 RT)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  42
TYR A 274
TYR A 271
PHE A  15
PRO A  10
 None
 1.20A 4ifvA-2o4cA:
undetectable		 4ifvA-2o4cA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFY_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  42
TYR A 274
TYR A 271
PHE A  15
PRO A  10
 None
 1.23A 4ifyA-2o4cA:
undetectable		 4ifyA-2o4cA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG3_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  42
TYR A 274
TYR A 271
PHE A  15
PRO A  10
 None
 1.18A 4ig3A-2o4cA:
undetectable		 4ig3A-2o4cA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFB_A_T27A607_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H,
EXORIBONUCLEA P66 RT)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  42
TYR A 274
TYR A 271
PHE A  15
PRO A  10
 None
 1.25A 4kfbA-2o4cA:
undetectable		 4kfbA-2o4cA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 8 LEU A 197
LEU A 227
LEU A 221
ILE A 171
VAL A 212
 None
 1.44A 4klaA-2o4cA:
5.2		 4klaA-2o4cA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 222
ARG A 247
GLN A 215
 None
 0.97A 4rtbA-2o4cA:
undetectable		 4rtbA-2o4cA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 255
GLY A 257
ALA A 256
ASP A 232
THR A 252
 None
NAD  A1002 (-3.4A)
NAD  A1002 (-3.7A)
NAD  A1002 (-4.0A)
None
 1.09A 4xt8A-2o4cA:
undetectable		 4xt8A-2o4cA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 135
ALA A 374
LEU A 310
LEU A 375
ARG A  93
 None
 1.30A 4zn7B-2o4cA:
undetectable		 4zn7B-2o4cA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 338
ASP A 241
ARG A 218
GLU A 222
 None
 0.90A 5btaA-2o4cA:
undetectable
5btaC-2o4cA:
undetectable
5btaD-2o4cA:
undetectable		 5btaA-2o4cA:
24.32
5btaC-2o4cA:
24.32
5btaD-2o4cA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 241
ARG A 218
GLU A 222
ARG A 338
 None
 0.93A 5btfA-2o4cA:
undetectable
5btfB-2o4cA:
undetectable
5btfC-2o4cA:
undetectable		 5btfA-2o4cA:
24.32
5btfB-2o4cA:
24.48
5btfC-2o4cA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 338
ASP A 241
ARG A 218
GLU A 222
 None
 0.79A 5btfA-2o4cA:
undetectable
5btfC-2o4cA:
undetectable
5btfD-2o4cA:
undetectable		 5btfA-2o4cA:
24.32
5btfC-2o4cA:
24.32
5btfD-2o4cA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 338
ASP A 241
ARG A 218
GLU A 222
 None
 0.83A 5btgA-2o4cA:
undetectable
5btgC-2o4cA:
undetectable
5btgD-2o4cA:
undetectable		 5btgA-2o4cA:
24.32
5btgC-2o4cA:
24.32
5btgD-2o4cA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EDL_A_VIBA201_1
(PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 349
GLU A 354
VAL A 317
ASP A 323
SER A 322
 None
 1.32A 5edlA-2o4cA:
0.0		 5edlA-2o4cA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 9 THR A  47
GLY A  63
THR A  66
THR A  64
ILE A 270
 None
None
PO4  A 900 (-3.9A)
None
None
 1.49A 5eeuA-2o4cA:
undetectable
5eeuB-2o4cA:
undetectable		 5eeuA-2o4cA:
10.85
5eeuB-2o4cA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 103
LEU A 104
GLY A 137
ARG A 370
 None
 0.95A 6ce2A-2o4cA:
undetectable		 6ce2A-2o4cA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 137
LEU A 138
VAL A 142
LEU A 100
 None
 0.77A 6czmD-2o4cA:
undetectable
6czmF-2o4cA:
undetectable		 6czmD-2o4cA:
23.80
6czmF-2o4cA:
23.80