SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2o4e O-GLCNACASE NAGJ
(Clostridium
perfringens) 		4 / 6 ASN A  71
ILE A  95
ASN A 138
THR A 137
 None
 1.06A 1h7xA-2o4eA:
undetectable		 1h7xA-2o4eA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2o4e O-GLCNACASE NAGJ
(Clostridium
perfringens) 		4 / 6 ASN A  71
ILE A  95
ASN A 138
THR A 137
 None
 1.06A 1h7xB-2o4eA:
undetectable		 1h7xB-2o4eA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2o4e O-GLCNACASE NAGJ
(Clostridium
perfringens) 		4 / 6 ASN A  71
ILE A  95
ASN A 138
THR A 137
 None
 1.05A 1h7xC-2o4eA:
undetectable		 1h7xC-2o4eA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2o4e O-GLCNACASE NAGJ
(Clostridium
perfringens) 		4 / 6 ASN A  71
ILE A  95
ASN A 138
THR A 137
 None
 1.06A 1h7xD-2o4eA:
undetectable		 1h7xD-2o4eA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2o4e O-GLCNACASE NAGJ
(Clostridium
perfringens) 		4 / 5 GLY A 153
ILE A 151
VAL A  53
SER A 139
 None
 0.93A 1rs7A-2o4eA:
undetectable		 1rs7A-2o4eA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2o4e O-GLCNACASE NAGJ
(Clostridium
perfringens) 		4 / 6 GLY A 153
ILE A 151
VAL A  53
SER A 139
 None
 1.02A 1rs7B-2o4eA:
undetectable		 1rs7B-2o4eA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2o4e O-GLCNACASE NAGJ
(Clostridium
perfringens) 		5 / 12 LEU A 134
LEU A  49
ASN A  48
ALA A 125
ILE A 160
 None
 1.18A 3ut5B-2o4eA:
undetectable		 3ut5B-2o4eA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 2o4e O-GLCNACASE NAGJ
(Clostridium
perfringens) 		5 / 12 LEU A 134
LEU A  49
ASN A  48
ALA A 125
ILE A 160
 None
 1.18A 3ut5D-2o4eA:
undetectable		 3ut5D-2o4eA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2o4e O-GLCNACASE NAGJ
(Clostridium
perfringens) 		4 / 5 GLY A 153
ILE A 151
VAL A  53
SER A 139
 None
 0.96A 4d33A-2o4eA:
undetectable		 4d33A-2o4eA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2o4e O-GLCNACASE NAGJ
(Clostridium
perfringens) 		4 / 5 GLY A 153
ILE A 151
VAL A  53
SER A 139
 None
 0.99A 4d33B-2o4eA:
undetectable		 4d33B-2o4eA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2o4e O-GLCNACASE NAGJ
(Clostridium
perfringens) 		4 / 6 GLY A 153
ILE A 151
VAL A  53
SER A 139
 None
 0.98A 4d39B-2o4eA:
undetectable		 4d39B-2o4eA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2o4e O-GLCNACASE NAGJ
(Clostridium
perfringens) 		4 / 6 GLY A 153
ILE A 151
VAL A  53
SER A 139
 None
 0.86A 4kcnA-2o4eA:
undetectable		 4kcnA-2o4eA:
23.39