SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o4t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 2o4t BH3976 PROTEIN
(Bacillus
halodurans) 		4 / 6 GLU A  61
GLY A  58
LEU A  23
TYR A  27
 None
 1.03A 3w9tB-2o4tA:
undetectable		 3w9tB-2o4tA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 2o4t BH3976 PROTEIN
(Bacillus
halodurans) 		4 / 6 GLU A  61
GLY A  58
LEU A  23
TYR A  27
 None
 1.03A 3w9tE-2o4tA:
undetectable		 3w9tE-2o4tA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 2o4t BH3976 PROTEIN
(Bacillus
halodurans) 		4 / 6 GLU A  61
GLY A  58
LEU A  23
TYR A  27
 None
 1.03A 3w9tF-2o4tA:
undetectable		 3w9tF-2o4tA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 2o4t BH3976 PROTEIN
(Bacillus
halodurans) 		4 / 6 LEU A  23
PHE A  60
THR A  74
VAL A  78
 None
None
None
PEG  A   1 (-4.1A)
 1.10A 4udaA-2o4tA:
undetectable		 4udaA-2o4tA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 2o4t BH3976 PROTEIN
(Bacillus
halodurans) 		4 / 5 TYR A  31
ILE A  34
GLY A  58
PHE A  59
 None
 0.94A 5kmdC-2o4tA:
3.0
5kmdD-2o4tA:
undetectable		 5kmdC-2o4tA:
15.22
5kmdD-2o4tA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 2o4t BH3976 PROTEIN
(Bacillus
halodurans) 		4 / 6 GLY A  58
GLU A  61
PHE A  59
ILE A  34
 None
 0.84A 5kmfA-2o4tA:
2.3
5kmfC-2o4tA:
undetectable		 5kmfA-2o4tA:
15.22
5kmfC-2o4tA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 2o4t BH3976 PROTEIN
(Bacillus
halodurans) 		4 / 6 GLY A  58
GLU A  61
PHE A  59
TYR A  31
 None
 0.72A 5kmfA-2o4tA:
2.3
5kmfC-2o4tA:
undetectable		 5kmfA-2o4tA:
15.22
5kmfC-2o4tA:
15.22