SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o4u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE
(Macaca
fascicularis) 		3 / 3 VAL X1031
VAL X1067
TRP X1005
 None
 0.78A 1av2A-2o4uX:
undetectable
1av2B-2o4uX:
undetectable		 1av2A-2o4uX:
3.08
1av2B-2o4uX:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE
(Macaca
fascicularis) 		3 / 3 VAL X1031
VAL X1034
TRP X1005
 None
 0.93A 1bdwA-2o4uX:
undetectable
1bdwB-2o4uX:
undetectable		 1bdwA-2o4uX:
3.08
1bdwB-2o4uX:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE
(Macaca
fascicularis) 		5 / 10 CYH X1228
LEU X1177
LEU X1158
PHE X1226
THR X1213
 None
None
GOL  X3001 ( 4.7A)
None
None
 1.28A 1i18A-2o4uX:
undetectable
1i18B-2o4uX:
undetectable		 1i18A-2o4uX:
16.42
1i18B-2o4uX:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE
(Macaca
fascicularis) 		5 / 10 CYH X1228
LEU X1177
THR X1231
PHE X1226
THR X1213
 None
 1.34A 1i18A-2o4uX:
undetectable
1i18B-2o4uX:
undetectable		 1i18A-2o4uX:
16.42
1i18B-2o4uX:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE
(Macaca
fascicularis) 		5 / 10 PHE X1226
THR X1213
CYH X1228
LEU X1177
LEU X1158
 None
None
None
None
GOL  X3001 ( 4.7A)
 1.29A 1i18A-2o4uX:
undetectable
1i18B-2o4uX:
undetectable		 1i18A-2o4uX:
16.42
1i18B-2o4uX:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE
(Macaca
fascicularis) 		5 / 10 PHE X1226
THR X1213
CYH X1228
LEU X1177
THR X1231
 None
 1.36A 1i18A-2o4uX:
undetectable
1i18B-2o4uX:
undetectable		 1i18A-2o4uX:
16.42
1i18B-2o4uX:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE
(Macaca
fascicularis) 		3 / 3 VAL X1031
VAL X1067
TRP X1005
 None
 0.93A 1w5uA-2o4uX:
undetectable
1w5uB-2o4uX:
undetectable		 1w5uA-2o4uX:
3.08
1w5uB-2o4uX:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE
(Macaca
fascicularis) 		3 / 3 VAL X1067
TRP X1005
VAL X1031
 None
 0.84A 2izqC-2o4uX:
undetectable
2izqD-2o4uX:
undetectable		 2izqC-2o4uX:
3.08
2izqD-2o4uX:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE
(Macaca
fascicularis) 		4 / 7 MET X1099
ARG X1114
VAL X1083
GLU X1122
 None
 1.19A 4jseA-2o4uX:
undetectable
4jseB-2o4uX:
undetectable		 4jseA-2o4uX:
21.04
4jseB-2o4uX:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE
(Macaca
fascicularis) 		4 / 7 MET X1099
ARG X1114
VAL X1093
GLU X1122
 None
 1.45A 4jseA-2o4uX:
undetectable
4jseB-2o4uX:
undetectable		 4jseA-2o4uX:
21.04
4jseB-2o4uX:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE
(Macaca
fascicularis) 		4 / 7 GLU X1122
MET X1099
ARG X1114
VAL X1083
 None
 1.22A 4jseA-2o4uX:
undetectable
4jseB-2o4uX:
undetectable		 4jseA-2o4uX:
21.04
4jseB-2o4uX:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE
(Macaca
fascicularis) 		4 / 7 GLU X1122
MET X1099
ARG X1114
VAL X1093
 None
 1.45A 4jseA-2o4uX:
undetectable
4jseB-2o4uX:
undetectable		 4jseA-2o4uX:
21.04
4jseB-2o4uX:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE
(Macaca
fascicularis) 		3 / 3 ARG X1322
GLU X1105
ARG X1323
 None
 0.91A 4mwvA-2o4uX:
undetectable		 4mwvA-2o4uX:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE
(Macaca
fascicularis) 		4 / 5 ILE X1317
ASP X1332
GLU X1320
VAL X1199
 None
PO4  X1338 ( 4.6A)
None
None
 1.18A 4nkxD-2o4uX:
undetectable		 4nkxD-2o4uX:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE
(Macaca
fascicularis) 		5 / 12 LEU X1177
GLY X1178
LEU X1318
ARG X1163
ILE X1185
 None
 1.26A 4okbA-2o4uX:
undetectable		 4okbA-2o4uX:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE
(Macaca
fascicularis) 		3 / 3 ASN X1278
SER X1015
SER X1014
 None
 0.74A 5gsnA-2o4uX:
4.2		 5gsnA-2o4uX:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE
(Macaca
fascicularis) 		5 / 12 VAL X1106
GLU X1122
ALA X1315
PRO X1098
LEU X1175
 None
 1.24A 5nd2B-2o4uX:
4.7		 5nd2B-2o4uX:
20.43