SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o4v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2o4v PORIN P
(Pseudomonas
aeruginosa) 		5 / 8 THR A  47
GLY A  50
GLY A 402
PHE A  42
GLY A 400
 None
 1.35A 1jhqA-2o4vA:
undetectable		 1jhqA-2o4vA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2o4v PORIN P
(Pseudomonas
aeruginosa) 		5 / 8 THR A  47
GLY A  50
GLY A 402
PHE A  42
GLY A 400
 None
 1.36A 1jhvA-2o4vA:
undetectable		 1jhvA-2o4vA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 2o4v PORIN P
(Pseudomonas
aeruginosa) 		5 / 12 PRO A 221
PHE A 245
GLY A 247
SER A 248
ALA A 294
 None
 1.22A 1nw5A-2o4vA:
undetectable		 1nw5A-2o4vA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 2o4v PORIN P
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 268
GLY A 270
GLY A 196
PHE A 319
 None
 0.76A 2c49B-2o4vA:
undetectable		 2c49B-2o4vA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 2o4v PORIN P
(Pseudomonas
aeruginosa) 		4 / 7 ASN A 173
ASP A 178
THR A 149
GLY A 148
 None
None
C8E  A1297 ( 4.7A)
None
 0.98A 2f6dA-2o4vA:
undetectable		 2f6dA-2o4vA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 2o4v PORIN P
(Pseudomonas
aeruginosa) 		4 / 8 TYR A 298
GLU A 264
HIS A 200
GLY A 265
 None
None
None
C8E  A1298 (-3.4A)
 1.09A 2ha4A-2o4vA:
undetectable		 2ha4A-2o4vA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 2o4v PORIN P
(Pseudomonas
aeruginosa) 		4 / 7 TYR A 298
GLU A 264
HIS A 200
GLY A 265
 None
None
None
C8E  A1298 (-3.4A)
 1.09A 2ha4B-2o4vA:
undetectable		 2ha4B-2o4vA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 2o4v PORIN P
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 202
HIS A 200
GLU A 277
ASP A 116
LEU A 203
 None
 1.00A 2x1lB-2o4vA:
undetectable		 2x1lB-2o4vA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2o4v PORIN P
(Pseudomonas
aeruginosa) 		3 / 3 TYR A 207
GLU A 286
ASP A 288
 None
 0.84A 3bxoA-2o4vA:
undetectable		 3bxoA-2o4vA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2o4v PORIN P
(Pseudomonas
aeruginosa) 		3 / 3 TYR A 207
GLU A 286
ASP A 288
 None
 0.81A 3bxoB-2o4vA:
undetectable		 3bxoB-2o4vA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 2o4v PORIN P
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 325
GLY A 307
THR A 306
 None
 0.52A 3iazA-2o4vA:
undetectable		 3iazA-2o4vA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2o4v PORIN P
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  33
GLU A  64
ASP A  80
ALA A  61
GLN A  36
 None
GOL  A 802 (-4.0A)
None
None
None
 1.11A 3id6C-2o4vA:
undetectable		 3id6C-2o4vA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 2o4v PORIN P
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  40
ARG A 226
ALA A 130
ASP A 138
ARG A 337
 None
 1.40A 3jzjA-2o4vA:
undetectable		 3jzjA-2o4vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2o4v PORIN P
(Pseudomonas
aeruginosa) 		3 / 3 TYR A 114
LEU A 314
LYS A 313
 PO4  A 805 (-4.4A)
None
None
 0.65A 3sueD-2o4vA:
undetectable		 3sueD-2o4vA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 2o4v PORIN P
(Pseudomonas
aeruginosa) 		3 / 3 PHE A 117
TYR A 298
TYR A 137
 None
 1.06A 4ffwA-2o4vA:
undetectable		 4ffwA-2o4vA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 2o4v PORIN P
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 222
GLY A 362
THR A 388
THR A 364
 None
 0.93A 4k87A-2o4vA:
undetectable		 4k87A-2o4vA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2o4v PORIN P
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 362
HIS A 365
ARG A 337
ALA A 299
TYR A  46
 None
 1.15A 5igvA-2o4vA:
undetectable		 5igvA-2o4vA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2o4v PORIN P
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 116
ASP A 141
ARG A 208
ASN A 184
 None
 1.27A 5l6eA-2o4vA:
undetectable		 5l6eA-2o4vA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 2o4v PORIN P
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 281
TYR A 205
ASP A 258
ASP A 216
 None
 1.00A 5vlmB-2o4vA:
undetectable		 5vlmB-2o4vA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 2o4v PORIN P
(Pseudomonas
aeruginosa) 		4 / 8 ILE A 219
ASN A 172
LEU A 292
LEU A 254
 None
 0.80A 5y7pE-2o4vA:
undetectable		 5y7pE-2o4vA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 2o4v PORIN P
(Pseudomonas
aeruginosa) 		4 / 9 ASP A 258
LEU A 185
VAL A 167
SER A 166
 None
None
C8E  A1297 (-4.5A)
None
 0.95A 6c2mD-2o4vA:
undetectable		 6c2mD-2o4vA:
11.08