SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o52'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2o52 RAS-RELATED PROTEIN
RAB-4B
(Homo
sapiens) 		4 / 5 ALA A  84
TYR A  78
ILE A 114
ASP A 105
 None
 1.09A 1upfA-2o52A:
3.8		 1upfA-2o52A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 2o52 RAS-RELATED PROTEIN
RAB-4B
(Homo
sapiens) 		3 / 3 TRP A 102
THR A  64
TYR A  77
 None
 0.98A 2a3aA-2o52A:
3.0		 2a3aA-2o52A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 2o52 RAS-RELATED PROTEIN
RAB-4B
(Homo
sapiens) 		3 / 3 TRP A 102
THR A  64
TYR A  77
 None
 1.03A 2a3aB-2o52A:
3.3		 2a3aB-2o52A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 2o52 RAS-RELATED PROTEIN
RAB-4B
(Homo
sapiens) 		3 / 3 TRP A 102
THR A  64
TYR A  77
 None
 1.01A 2a3bA-2o52A:
3.0		 2a3bA-2o52A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 2o52 RAS-RELATED PROTEIN
RAB-4B
(Homo
sapiens) 		4 / 5 LEU A 148
LEU A  24
CYH A 165
THR A 168
 None
 1.21A 2oaxD-2o52A:
undetectable		 2oaxD-2o52A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 2o52 RAS-RELATED PROTEIN
RAB-4B
(Homo
sapiens) 		5 / 9 ALA A 106
ASP A 105
VAL A 116
LEU A  86
ILE A 114
 None
 1.43A 3wsjA-2o52A:
undetectable		 3wsjA-2o52A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 2o52 RAS-RELATED PROTEIN
RAB-4B
(Homo
sapiens) 		5 / 11 ALA A 152
GLY A  18
GLU A  94
ASN A  97
ASN A 121
 GDP  A 601 (-3.6A)
GDP  A 601 (-3.5A)
None
None
GDP  A 601 (-3.3A)
 1.09A 4dcmA-2o52A:
3.6		 4dcmA-2o52A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2o52 RAS-RELATED PROTEIN
RAB-4B
(Homo
sapiens) 		5 / 7 VAL A  52
VAL A  57
LYS A  55
PHE A   7
ASP A 174
 None
 1.03A 5yf9B-2o52A:
undetectable		 5yf9B-2o52A:
18.69