SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o5f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2o5f PUTATIVE NUDIX
HYDROLASE DR_0079
(Deinococcus
radiodurans) 		3 / 3 TRP A  99
VAL A  72
ARG A  24
 None
 0.92A 3b0wA-2o5fA:
undetectable		 3b0wA-2o5fA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2o5f PUTATIVE NUDIX
HYDROLASE DR_0079
(Deinococcus
radiodurans) 		5 / 10 VAL A  36
ASP A 158
LEU A  29
ARG A  24
VAL A  34
 None
 1.39A 4eilB-2o5fA:
undetectable		 4eilB-2o5fA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2o5f PUTATIVE NUDIX
HYDROLASE DR_0079
(Deinococcus
radiodurans) 		5 / 12 VAL A  36
ASP A 158
LEU A  29
ARG A  24
VAL A  34
 None
 1.39A 4kyaB-2o5fA:
undetectable		 4kyaB-2o5fA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2o5f PUTATIVE NUDIX
HYDROLASE DR_0079
(Deinococcus
radiodurans) 		5 / 12 VAL A  36
ASP A 158
LEU A  29
ARG A  24
VAL A  34
 None
 1.38A 4kyaD-2o5fA:
undetectable		 4kyaD-2o5fA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2o5f PUTATIVE NUDIX
HYDROLASE DR_0079
(Deinococcus
radiodurans) 		5 / 12 VAL A  36
ASP A 158
LEU A  29
ARG A  24
VAL A  34
 None
 1.37A 4kyaH-2o5fA:
undetectable		 4kyaH-2o5fA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 2o5f PUTATIVE NUDIX
HYDROLASE DR_0079
(Deinococcus
radiodurans) 		5 / 12 PRO A 101
ASP A  95
LEU A 121
PHE A  82
ILE A  94
 None
 1.37A 5dv4A-2o5fA:
undetectable		 5dv4A-2o5fA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 2o5f PUTATIVE NUDIX
HYDROLASE DR_0079
(Deinococcus
radiodurans) 		5 / 12 TYR A  78
PRO A 101
ALA A 103
THR A 111
GLU A 161
 None
 1.43A 5ewjC-2o5fA:
undetectable
5ewjD-2o5fA:
undetectable		 5ewjC-2o5fA:
18.86
5ewjD-2o5fA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2o5f PUTATIVE NUDIX
HYDROLASE DR_0079
(Deinococcus
radiodurans) 		3 / 3 GLU A 143
HIS A 144
ARG A 148
 None
 0.85A 5uunA-2o5fA:
undetectable		 5uunA-2o5fA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2o5f PUTATIVE NUDIX
HYDROLASE DR_0079
(Deinococcus
radiodurans) 		3 / 3 LEU A 112
SER A 106
PHE A 105
 None
 0.54A 6fgcA-2o5fA:
undetectable		 6fgcA-2o5fA:
16.63