SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o5h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2o5h HYPOTHETICAL PROTEIN
(Neisseria
meningitidis) 		5 / 12 ILE A  73
ALA A 119
LEU A  60
ILE A  84
ILE A  74
 None
 1.13A 1re7A-2o5hA:
undetectable		 1re7A-2o5hA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2o5h HYPOTHETICAL PROTEIN
(Neisseria
meningitidis) 		5 / 12 MET A 109
GLY A 108
TRP A 110
THR A  49
PHE A 105
 None
 1.29A 3ag4A-2o5hA:
1.1
3ag4B-2o5hA:
0.0
3ag4T-2o5hA:
0.0		 3ag4A-2o5hA:
13.45
3ag4B-2o5hA:
20.83
3ag4T-2o5hA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2o5h HYPOTHETICAL PROTEIN
(Neisseria
meningitidis) 		3 / 3 ILE A  54
PHE A  41
HIS A   7
 None
 0.67A 3h0aA-2o5hA:
undetectable		 3h0aA-2o5hA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 2o5h HYPOTHETICAL PROTEIN
(Neisseria
meningitidis) 		4 / 8 PHE A  56
PHE A  53
PHE A  52
ALA A 115
 None
 0.90A 3t3sD-2o5hA:
undetectable		 3t3sD-2o5hA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 2o5h HYPOTHETICAL PROTEIN
(Neisseria
meningitidis) 		5 / 12 PRO A 116
PHE A  85
PHE A  56
ILE A  84
HIS A  76
 None
 1.44A 4yfbC-2o5hA:
0.0		 4yfbC-2o5hA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 2o5h HYPOTHETICAL PROTEIN
(Neisseria
meningitidis) 		5 / 12 PRO A 116
PHE A  85
PHE A  56
ILE A  84
HIS A  76
 None
 1.45A 4yfbI-2o5hA:
undetectable		 4yfbI-2o5hA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 2o5h HYPOTHETICAL PROTEIN
(Neisseria
meningitidis) 		5 / 12 PRO A 116
PHE A  85
PHE A  56
ILE A  84
HIS A  76
 None
 1.45A 4yfbL-2o5hA:
undetectable		 4yfbL-2o5hA:
13.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 2o5h HYPOTHETICAL PROTEIN
(Neisseria
meningitidis) 		3 / 3 TYR A 130
PRO A  30
LEU A  29
 None
 0.93A 6beoA-2o5hA:
undetectable		 6beoA-2o5hA:
38.46