SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o5p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		3 / 3 GLN A 136
TYR A  72
ARG A  73
 None
 0.92A 1gtbA-2o5pA:
undetectable		 1gtbA-2o5pA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 768
SER A 778
ASN A 780
ASP A 179
 None
 1.37A 1hwiC-2o5pA:
undetectable		 1hwiC-2o5pA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 768
SER A 778
ASN A 780
ASP A 179
 None
 1.37A 1hwiD-2o5pA:
undetectable		 1hwiD-2o5pA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 643
THR A 706
VAL A 704
 None
 0.87A 1hxbA-2o5pA:
undetectable		 1hxbA-2o5pA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 9 GLY A  63
ASP A  67
ILE A  85
VAL A 106
ILE A 113
 None
 1.10A 1hxwA-2o5pA:
undetectable		 1hxwA-2o5pA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 11 ASN A 630
LEU A 160
GLY A 622
ARG A 536
PHE A 546
 None
 1.43A 1l5rA-2o5pA:
undetectable		 1l5rA-2o5pA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 4 ASP A 814
HIS A 280
ARG A 812
GLU A 282
 PO4  A   9 ( 4.9A)
PO4  A  10 ( 3.5A)
PO4  A   4 ( 2.6A)
PO4  A  10 (-3.0A)
 1.18A 1lqtA-2o5pA:
undetectable		 1lqtA-2o5pA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		3 / 3 THR A 462
GLU A 403
ASP A 339
 None
 0.79A 1nt2A-2o5pA:
undetectable		 1nt2A-2o5pA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 593
ALA A 259
ILE A 563
PRO A 595
 None
 1.11A 1oniH-2o5pA:
undetectable
1oniI-2o5pA:
undetectable		 1oniH-2o5pA:
11.04
1oniI-2o5pA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QLT_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 219
PHE A 217
ILE A 185
TYR A 243
 None
 1.48A 1qltA-2o5pA:
0.3		 1qltA-2o5pA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QLT_B_ACTB601_0
(VANILLYL-ALCOHOL
OXIDASE)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 219
PHE A 217
ILE A 185
TYR A 243
 None
 1.49A 1qltB-2o5pA:
undetectable		 1qltB-2o5pA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 6 SER A 705
ILE A 696
ALA A 668
ALA A 644
 None
 0.99A 1w0gA-2o5pA:
undetectable		 1w0gA-2o5pA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		3 / 3 PHE A 217
ARG A 245
ASN A 267
 None
 0.90A 1xzxX-2o5pA:
undetectable		 1xzxX-2o5pA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 5 LEU A  98
PRO A  91
ALA A  94
ILE A  95
 None
 0.90A 2aofB-2o5pA:
undetectable		 2aofB-2o5pA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		3 / 3 TYR A 635
GLY A 619
PHE A 636
 None
 0.72A 2m2pB-2o5pA:
undetectable		 2m2pB-2o5pA:
3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 244
THR A 192
PRO A 193
 None
 0.58A 2pynB-2o5pA:
undetectable		 2pynB-2o5pA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 643
THR A 706
VAL A 704
 None
 0.43A 2q64A-2o5pA:
undetectable		 2q64A-2o5pA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 244
THR A 192
PRO A 193
 None
 0.54A 2q64B-2o5pA:
undetectable		 2q64B-2o5pA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 185
SER A 238
ARG A 270
ILE A 269
 None
 0.84A 2q72A-2o5pA:
undetectable		 2q72A-2o5pA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 643
THR A 706
VAL A 704
 None
 0.72A 2qakA-2o5pA:
undetectable		 2qakA-2o5pA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 244
THR A 192
PRO A 193
 None
 0.58A 2qakB-2o5pA:
undetectable		 2qakB-2o5pA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 197
TYR A 207
ILE A 185
ASP A 187
 None
None
None
PO4  A   3 (-4.0A)
 1.26A 2x45B-2o5pA:
undetectable		 2x45B-2o5pA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 197
TYR A 207
ILE A 185
ASP A 187
 None
None
None
PO4  A   3 (-4.0A)
 1.24A 2x45C-2o5pA:
undetectable		 2x45C-2o5pA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 108
ASP A  67
PRO A  91
VAL A  46
PHE A  48
 None
 1.04A 2zulA-2o5pA:
undetectable		 2zulA-2o5pA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 197
TYR A 207
ILE A 185
ASP A 187
 None
None
None
PO4  A   3 (-4.0A)
 1.15A 3bu1A-2o5pA:
undetectable		 3bu1A-2o5pA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 108
ASP A  67
PRO A  91
VAL A  46
PHE A  48
 None
 0.99A 3dmfA-2o5pA:
undetectable		 3dmfA-2o5pA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 108
ASP A  67
PRO A  91
VAL A  46
PHE A  48
 None
 1.02A 3dmhA-2o5pA:
undetectable		 3dmhA-2o5pA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 4 PRO A 464
THR A 462
GLY A 138
THR A 139
 None
 1.16A 3ib1A-2o5pA:
undetectable		 3ib1A-2o5pA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 12 THR A 329
SER A 390
ASP A 201
ASP A 239
LEU A 237
 None
 1.25A 3iv6D-2o5pA:
undetectable		 3iv6D-2o5pA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 138
THR A 151
GLN A  69
THR A 133
 None
 0.94A 3rglA-2o5pA:
undetectable		 3rglA-2o5pA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 7 THR A 154
GLY A 221
ASN A 267
GLY A 258
 None
 0.81A 3tajA-2o5pA:
undetectable		 3tajA-2o5pA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 244
THR A 192
PRO A 193
 None
 0.65A 3tkgD-2o5pA:
undetectable		 3tkgD-2o5pA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 409
TYR A  72
GLY A  56
SER A  57
LEU A 461
 None
 1.20A 4blvB-2o5pA:
undetectable		 4blvB-2o5pA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 803
ASP A 187
ASP A 203
ASN A 184
 None
PO4  A   3 (-4.0A)
None
PO4  A   3 (-3.4A)
 1.20A 4feuB-2o5pA:
undetectable		 4feuB-2o5pA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 803
ASP A 187
ASP A 203
ASN A 184
 None
PO4  A   3 (-4.0A)
None
PO4  A   3 (-3.4A)
 1.22A 4fevD-2o5pA:
undetectable		 4fevD-2o5pA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 803
ASP A 187
ASP A 203
ASN A 184
 None
PO4  A   3 (-4.0A)
None
PO4  A   3 (-3.4A)
 1.21A 4fevF-2o5pA:
undetectable		 4fevF-2o5pA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 803
ASP A 187
ASP A 203
ASN A 184
 None
PO4  A   3 (-4.0A)
None
PO4  A   3 (-3.4A)
 1.21A 4fewB-2o5pA:
undetectable		 4fewB-2o5pA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 803
ASP A 187
ASP A 203
ASN A 184
 None
PO4  A   3 (-4.0A)
None
PO4  A   3 (-3.4A)
 1.23A 4fexB-2o5pA:
undetectable		 4fexB-2o5pA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 6 THR A 154
GLY A 221
ASN A 267
GLY A 258
 None
 0.83A 4fjpA-2o5pA:
undetectable		 4fjpA-2o5pA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 7 THR A 154
GLY A 221
ASN A 267
GLY A 258
 None
 0.80A 4forA-2o5pA:
undetectable		 4forA-2o5pA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 803
ASP A 187
ASP A 203
ASN A 184
 None
PO4  A   3 (-4.0A)
None
PO4  A   3 (-3.4A)
 1.20A 4gkhB-2o5pA:
undetectable		 4gkhB-2o5pA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 803
ASP A 187
ASP A 203
ASN A 184
 None
PO4  A   3 (-4.0A)
None
PO4  A   3 (-3.4A)
 1.21A 4gkhG-2o5pA:
undetectable		 4gkhG-2o5pA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 803
ASP A 187
ASP A 203
ASN A 184
 None
PO4  A   3 (-4.0A)
None
PO4  A   3 (-3.4A)
 1.20A 4gkhJ-2o5pA:
undetectable		 4gkhJ-2o5pA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 803
ASP A 187
ASP A 203
ASN A 184
 None
PO4  A   3 (-4.0A)
None
PO4  A   3 (-3.4A)
 1.21A 4gkiC-2o5pA:
undetectable		 4gkiC-2o5pA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 237
MET A 240
TYR A 352
 None
 0.90A 4p6xG-2o5pA:
undetectable		 4p6xG-2o5pA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  98
GLY A  56
PHE A  62
ASN A 405
ALA A  54
 None
 1.28A 4pclB-2o5pA:
undetectable		 4pclB-2o5pA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 8 LEU A  98
VAL A  70
VAL A 106
TYR A  72
 None
 1.01A 4pwdA-2o5pA:
undetectable		 4pwdA-2o5pA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 634
GLY A 672
ALA A 264
GLY A 251
PHE A 636
 None
 1.21A 4r29A-2o5pA:
undetectable		 4r29A-2o5pA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 634
GLY A 672
ALA A 264
GLY A 251
PHE A 636
 None
 1.22A 4r29B-2o5pA:
undetectable		 4r29B-2o5pA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 567
ARG A 568
GLU A 565
PHE A 593
 None
 1.17A 4r82A-2o5pA:
undetectable
4r82B-2o5pA:
undetectable		 4r82A-2o5pA:
14.68
4r82B-2o5pA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 7 THR A 156
LEU A 158
THR A 165
LEU A 160
THR A 534
 None
 1.39A 4z90A-2o5pA:
undetectable
4z90B-2o5pA:
undetectable
4z90C-2o5pA:
undetectable
4z90D-2o5pA:
undetectable
4z90E-2o5pA:
undetectable		 4z90A-2o5pA:
18.18
4z90B-2o5pA:
18.18
4z90C-2o5pA:
18.18
4z90D-2o5pA:
18.18
4z90E-2o5pA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 4 ASN A 267
ILE A 570
TYR A 532
PHE A 546
 None
 1.23A 5igvA-2o5pA:
0.8		 5igvA-2o5pA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 239
ASP A 220
ARG A 245
ASN A 267
 None
 1.21A 5l6eA-2o5pA:
undetectable		 5l6eA-2o5pA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 5 ASN A 184
ASP A 186
ASN A 205
ASP A 201
 PO4  A   3 (-3.4A)
PO4  A   3 (-3.7A)
PO4  A   3 (-4.1A)
None
 1.32A 5vooA-2o5pA:
undetectable		 5vooA-2o5pA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 5 ASN A 184
ASP A 186
ASN A 205
ASP A 201
 PO4  A   3 (-3.4A)
PO4  A   3 (-3.7A)
PO4  A   3 (-4.1A)
None
 1.36A 5vooC-2o5pA:
undetectable		 5vooC-2o5pA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 5 ASN A 184
ASP A 186
ASN A 205
ASP A 201
 PO4  A   3 (-3.4A)
PO4  A   3 (-3.7A)
PO4  A   3 (-4.1A)
None
 1.26A 5vooE-2o5pA:
undetectable		 5vooE-2o5pA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 425
PRO A 426
LYS A 358
GLY A 234
ASP A 356
 None
PO4  A   1 (-4.2A)
None
None
None
 1.05A 5wwsB-2o5pA:
undetectable		 5wwsB-2o5pA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 802
THR A 791
GLN A 757
TYR A 760
 None
 1.28A 6ag0C-2o5pA:
undetectable		 6ag0C-2o5pA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 757
THR A 791
HIS A 191
LEU A 762
 None
 1.13A 6aphA-2o5pA:
undetectable		 6aphA-2o5pA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 7 PHE A  48
ILE A  85
ILE A  68
ALA A 104
 None
 0.77A 6b5vA-2o5pA:
undetectable
6b5vC-2o5pA:
undetectable		 6b5vA-2o5pA:
7.16
6b5vC-2o5pA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 104
PHE A  48
ILE A  85
ILE A  68
 None
 0.78A 6b5vA-2o5pA:
undetectable
6b5vB-2o5pA:
undetectable		 6b5vA-2o5pA:
7.16
6b5vB-2o5pA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 7 PHE A  48
ILE A  85
ILE A  68
ALA A 104
 None
 0.77A 6b5vC-2o5pA:
undetectable
6b5vD-2o5pA:
undetectable		 6b5vC-2o5pA:
7.16
6b5vD-2o5pA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 104
PHE A  48
ILE A  85
ILE A  68
 None
 0.77A 6b5vB-2o5pA:
undetectable
6b5vD-2o5pA:
undetectable		 6b5vB-2o5pA:
7.16
6b5vD-2o5pA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 128
ASP A 578
SER A 584
ARG A 163
 None
 1.17A 6dwdA-2o5pA:
undetectable
6dwdC-2o5pA:
undetectable		 6dwdA-2o5pA:
21.58
6dwdC-2o5pA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 757
THR A 791
HIS A 191
LEU A 762
 None
 1.12A 6gbnB-2o5pA:
undetectable		 6gbnB-2o5pA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 2o5p FERRIPYOVERDINE
RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 548
LEU A 547
GLY A 463
PRO A  74
PRO A 166
 None
 1.04A 6gngB-2o5pA:
undetectable		 6gngB-2o5pA:
21.15