SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o5r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 5 TYR A 268
PRO A 270
LEU A  63
THR A 258
 None
 1.31A 1i2wA-2o5rA:
undetectable		 1i2wA-2o5rA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 8 LEU A  14
LEU A 273
LEU A  65
ARG A 264
 None
 1.06A 2xn3A-2o5rA:
undetectable
2xn3B-2o5rA:
undetectable		 2xn3A-2o5rA:
21.63
2xn3B-2o5rA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BMC_A_FOLA270_0
(PTERIDINE REDUCTASE)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		5 / 11 ARG A 435
PHE A 378
VAL A 448
PRO A 445
GLU A 363
 CL  A 472 (-4.5A)
None
None
None
None
 1.26A 3bmcA-2o5rA:
2.3		 3bmcA-2o5rA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_A_CE3A303_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 4 ASN A 275
SER A 299
SER A 301
ARG A 304
 None
 1.29A 3hlwA-2o5rA:
0.0		 3hlwA-2o5rA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 5 ASN A 275
SER A 299
SER A 301
ARG A 304
 None
 1.28A 3hlwB-2o5rA:
undetectable		 3hlwB-2o5rA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		5 / 9 ILE A 330
PHE A 378
PHE A 379
PHE A 371
PHE A 341
 None
 1.04A 3ko0A-2o5rA:
undetectable
3ko0C-2o5rA:
undetectable		 3ko0A-2o5rA:
12.33
3ko0C-2o5rA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 8 ILE A 330
PHE A 379
PHE A 371
PHE A 341
 None
 0.88A 3ko0B-2o5rA:
undetectable
3ko0J-2o5rA:
undetectable		 3ko0B-2o5rA:
12.33
3ko0J-2o5rA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 8 PHE A 378
PHE A 379
PHE A 371
PHE A 341
 None
 1.03A 3ko0B-2o5rA:
undetectable
3ko0J-2o5rA:
undetectable		 3ko0B-2o5rA:
12.33
3ko0J-2o5rA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC201_1
(PROTEIN S100-A4)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		5 / 9 PHE A 371
PHE A 341
ILE A 330
PHE A 378
PHE A 379
 None
 1.13A 3ko0A-2o5rA:
0.6
3ko0C-2o5rA:
undetectable		 3ko0A-2o5rA:
12.33
3ko0C-2o5rA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 7 PHE A 371
PHE A 341
PHE A 378
PHE A 379
 None
 1.10A 3ko0D-2o5rA:
undetectable
3ko0E-2o5rA:
undetectable		 3ko0D-2o5rA:
12.33
3ko0E-2o5rA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 7 PHE A 378
PHE A 379
PHE A 371
PHE A 341
 None
 0.98A 3ko0D-2o5rA:
undetectable
3ko0E-2o5rA:
undetectable		 3ko0D-2o5rA:
12.33
3ko0E-2o5rA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 5 PHE A 371
PHE A 341
PHE A 378
PHE A 379
 None
 1.08A 3ko0F-2o5rA:
undetectable
3ko0G-2o5rA:
0.0		 3ko0F-2o5rA:
12.33
3ko0G-2o5rA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 5 PHE A 378
PHE A 379
PHE A 371
PHE A 341
 None
 1.05A 3ko0F-2o5rA:
undetectable
3ko0G-2o5rA:
0.0		 3ko0F-2o5rA:
12.33
3ko0G-2o5rA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 8 ILE A 330
PHE A 379
PHE A 371
PHE A 341
 None
 0.89A 3ko0K-2o5rA:
undetectable
3ko0S-2o5rA:
undetectable		 3ko0K-2o5rA:
12.33
3ko0S-2o5rA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 8 PHE A 378
PHE A 379
PHE A 371
PHE A 341
 None
 1.05A 3ko0K-2o5rA:
undetectable
3ko0S-2o5rA:
undetectable		 3ko0K-2o5rA:
12.33
3ko0S-2o5rA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 7 PHE A 371
PHE A 341
PHE A 378
PHE A 379
 None
 0.98A 3ko0L-2o5rA:
undetectable
3ko0N-2o5rA:
undetectable		 3ko0L-2o5rA:
12.33
3ko0N-2o5rA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 7 PHE A 378
PHE A 379
PHE A 371
PHE A 341
 None
 0.94A 3ko0L-2o5rA:
undetectable
3ko0N-2o5rA:
undetectable		 3ko0L-2o5rA:
12.33
3ko0N-2o5rA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		5 / 10 PHE A 371
PHE A 341
ILE A 330
PHE A 378
PHE A 379
 None
 1.01A 3ko0L-2o5rA:
undetectable
3ko0N-2o5rA:
undetectable		 3ko0L-2o5rA:
12.33
3ko0N-2o5rA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 8 PHE A 371
PHE A 341
ILE A 330
PHE A 379
 None
 0.91A 3ko0O-2o5rA:
undetectable
3ko0Q-2o5rA:
undetectable		 3ko0O-2o5rA:
12.33
3ko0Q-2o5rA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 6 PHE A 430
PHE A 395
HIS A 423
VAL A 425
 None
 1.23A 3lb3A-2o5rA:
undetectable		 3lb3A-2o5rA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 6 PHE A 430
PHE A 395
HIS A 423
VAL A 425
 None
 1.31A 3lb3B-2o5rA:
undetectable		 3lb3B-2o5rA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		5 / 12 ALA A 257
VAL A  16
GLY A  18
ALA A  19
LEU A  65
 None
 1.06A 3ln1A-2o5rA:
undetectable		 3ln1A-2o5rA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		5 / 12 ALA A 257
VAL A  16
GLY A  18
ALA A  19
LEU A  65
 None
 1.07A 3ln1B-2o5rA:
undetectable		 3ln1B-2o5rA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		5 / 12 ALA A 257
VAL A  16
GLY A  18
ALA A  19
LEU A  65
 None
 1.07A 3ln1C-2o5rA:
undetectable		 3ln1C-2o5rA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		5 / 12 ALA A 257
VAL A  16
GLY A  18
ALA A  19
LEU A  65
 None
 1.06A 3ln1D-2o5rA:
undetectable		 3ln1D-2o5rA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 7 VAL A 405
VAL A 419
PHE A 416
ILE A 451
 None
 0.95A 3zjqA-2o5rA:
undetectable		 3zjqA-2o5rA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 7 VAL A 405
VAL A 419
PHE A 416
ILE A 451
 None
 0.96A 3zjqB-2o5rA:
undetectable		 3zjqB-2o5rA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 6 GLY A  74
ARG A  61
GLU A  53
ARG A  81
 None
 1.30A 4bqfA-2o5rA:
undetectable		 4bqfA-2o5rA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		5 / 12 ALA A 257
VAL A  16
GLY A  18
ALA A  19
LEU A  65
 None
 1.08A 5jw1B-2o5rA:
undetectable		 5jw1B-2o5rA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		5 / 12 LEU A 280
LYS A 170
ASP A 214
GLY A 213
ALA A  19
 None
 1.33A 5kc4A-2o5rA:
undetectable		 5kc4A-2o5rA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 8 GLU A  84
PRO A  71
GLY A  78
PRO A  79
 None
 1.09A 5kf8A-2o5rA:
undetectable		 5kf8A-2o5rA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 8 ARG A  81
GLU A  84
GLY A  78
PRO A  79
 None
 1.13A 5kgpA-2o5rA:
undetectable		 5kgpA-2o5rA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 8 ARG A  81
GLU A  84
GLY A  78
PRO A  79
 None
 1.12A 5kgpB-2o5rA:
undetectable		 5kgpB-2o5rA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 4 LEU A 434
ARG A 462
ILE A 463
PHE A 459
 None
 1.08A 5kirB-2o5rA:
undetectable		 5kirB-2o5rA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		5 / 12 ILE A 243
GLY A  17
HIS A  15
VAL A 260
ALA A 310
 None
 1.26A 5n0xB-2o5rA:
undetectable		 5n0xB-2o5rA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 2o5r GLUTAMYL-TRNA
SYNTHETASE 1
(Thermotoga
maritima) 		4 / 8 GLY A  75
ILE A  37
ASP A  68
ASP A  72
 None
 0.96A 5vlmH-2o5rA:
undetectable		 5vlmH-2o5rA:
16.88