SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o5v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		4 / 7 LEU A   6
LEU A  76
SER A  81
SER A  83
 None
 0.87A 1dvxA-2o5vA:
undetectable		 1dvxA-2o5vA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		4 / 7 LEU A   9
LEU A  12
GLY A  20
LEU A  17
 None
 0.95A 1gtiA-2o5vA:
undetectable		 1gtiA-2o5vA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_A_DAHA382_1
(AMINE OXIDASE)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		5 / 10 THR A 226
ASP A 230
TYR A 227
VAL A 245
HIS A 249
 None
 1.31A 1ivvA-2o5vA:
undetectable		 1ivvA-2o5vA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_B_DAHB382_1
(AMINE OXIDASE)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		5 / 10 THR A 226
ASP A 230
TYR A 227
VAL A 245
HIS A 249
 None
 1.36A 1ivvB-2o5vA:
undetectable		 1ivvB-2o5vA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		3 / 3 GLU A 148
GLU A 154
LEU A 179
 None
 0.74A 1v8bA-2o5vA:
undetectable		 1v8bA-2o5vA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		4 / 8 SER A 319
LEU A 316
ARG A 280
GLU A 284
 None
 1.06A 2j2pA-2o5vA:
undetectable
2j2pB-2o5vA:
undetectable		 2j2pA-2o5vA:
19.45
2j2pB-2o5vA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		5 / 12 LEU A 218
LEU A 135
ILE A 186
TYR A 153
GLU A 185
 None
 1.14A 2weyA-2o5vA:
undetectable		 2weyA-2o5vA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		3 / 3 GLY A 147
TYR A 146
SER A 140
 None
 0.76A 2xatA-2o5vA:
undetectable		 2xatA-2o5vA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		5 / 12 LEU A 150
SER A 151
ARG A 190
SER A 137
LEU A 135
 None
 1.31A 3bxoA-2o5vA:
undetectable		 3bxoA-2o5vA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		3 / 3 GLU A 119
ASP A 120
ASP A  55
 None
 0.74A 3jb2A-2o5vA:
undetectable		 3jb2A-2o5vA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		3 / 3 ASP A 251
ARG A 190
ARG A 234
 None
 1.00A 3k37A-2o5vA:
undetectable		 3k37A-2o5vA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		4 / 7 LEU A   6
LEU A  76
SER A  83
VAL A  87
 None
 1.03A 3ozkB-2o5vA:
undetectable		 3ozkB-2o5vA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		5 / 12 LEU A 135
ALA A 133
ARG A 279
GLY A 147
LEU A 150
 None
 1.15A 3q95A-2o5vA:
undetectable		 3q95A-2o5vA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		5 / 11 LEU A 135
ALA A 133
ARG A 279
GLY A 147
LEU A 150
 None
 1.15A 3uudA-2o5vA:
undetectable		 3uudA-2o5vA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		5 / 9 GLY A 343
LEU A 338
LEU A  42
ASN A  16
ILE A  31
 None
 1.19A 3wdmC-2o5vA:
undetectable		 3wdmC-2o5vA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		5 / 10 GLY A 343
LEU A 338
LEU A  42
ASN A  16
ILE A  31
 None
 1.06A 3wdmD-2o5vA:
undetectable		 3wdmD-2o5vA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		3 / 3 ARG A 160
GLU A 238
ASN A 161
 None
 0.86A 4imaD-2o5vA:
2.1		 4imaD-2o5vA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		3 / 3 ARG A 160
GLU A 238
ASN A 161
 None
 0.83A 4ip7D-2o5vA:
undetectable		 4ip7D-2o5vA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		5 / 12 SER A  83
LEU A  76
ALA A 103
GLY A  52
LEU A  96
 None
 1.15A 4j7xB-2o5vA:
undetectable		 4j7xB-2o5vA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		4 / 6 ARG A 117
GLU A 122
ASP A 120
ARG A 279
 None
 1.40A 4kcnA-2o5vA:
undetectable		 4kcnA-2o5vA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		3 / 3 TYR A 227
GLY A 247
PRO A 248
 None
 0.68A 4qwpA-2o5vA:
0.6		 4qwpA-2o5vA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		4 / 6 ALA A 229
THR A 246
THR A 222
TYR A 227
 None
 1.24A 4z4fA-2o5vA:
undetectable		 4z4fA-2o5vA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		4 / 5 ALA A 229
THR A 246
THR A 222
TYR A 227
 None
 1.22A 4z4gA-2o5vA:
undetectable		 4z4gA-2o5vA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		4 / 6 ALA A 229
THR A 246
THR A 222
TYR A 227
 None
 1.23A 4z4iA-2o5vA:
undetectable		 4z4iA-2o5vA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		4 / 6 LEU A   6
LEU A  76
SER A  83
VAL A  87
 None
 0.98A 5a6iA-2o5vA:
undetectable		 5a6iA-2o5vA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		4 / 5 THR A 222
GLY A 247
GLU A 237
ASP A 230
 None
 0.92A 5c0oH-2o5vA:
undetectable		 5c0oH-2o5vA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		4 / 5 THR A 222
GLY A 247
GLU A 238
ASP A 230
 None
 1.23A 5c0oH-2o5vA:
undetectable		 5c0oH-2o5vA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		5 / 10 LEU A 135
ALA A 133
ARG A 279
GLY A 147
LEU A 150
 None
 1.19A 5dxbA-2o5vA:
undetectable		 5dxbA-2o5vA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		5 / 12 LEU A  48
ARG A  93
ILE A  59
GLY A  90
ILE A  63
 None
 1.12A 5ifuA-2o5vA:
undetectable		 5ifuA-2o5vA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		5 / 12 ALA A 113
VAL A 114
TYR A  47
ALA A 331
ALA A 317
 None
 1.20A 5n5dA-2o5vA:
undetectable		 5n5dA-2o5vA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		6 / 12 LEU A 253
LEU A 278
ALA A 277
LEU A 216
THR A 217
GLY A 258
 None
 1.18A 6b0cD-2o5vA:
undetectable		 6b0cD-2o5vA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		5 / 10 ILE A 324
VAL A  72
LEU A   9
LEU A   6
LEU A  43
 None
 0.89A 6f6nA-2o5vA:
undetectable
6f6nB-2o5vA:
undetectable		 6f6nA-2o5vA:
12.20
6f6nB-2o5vA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		4 / 6 VAL A  72
LEU A   9
LEU A   6
LEU A  43
 None
 0.80A 6f6sA-2o5vA:
undetectable
6f6sB-2o5vA:
0.0		 6f6sA-2o5vA:
12.20
6f6sB-2o5vA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF
(Deinococcus
radiodurans) 		4 / 6 LEU A  17
THR A  11
GLY A  20
ARG A 344
 None
 1.22A 6gtqB-2o5vA:
undetectable
6gtqD-2o5vA:
undetectable		 6gtqB-2o5vA:
20.11
6gtqD-2o5vA:
8.22