SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o5w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2o5w DATP
PYROPHOSPHOHYDROLASE
(Escherichia
coli) 		4 / 7 LEU A  70
GLN A 112
LEU A  27
VAL A  57
 None
 0.76A 3g8iA-2o5wA:
undetectable		 3g8iA-2o5wA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5V_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 2o5w DATP
PYROPHOSPHOHYDROLASE
(Escherichia
coli) 		4 / 7 ARG A  77
VAL A  15
PHE A 145
GLU A 143
 None
 1.49A 3n5vA-2o5wA:
undetectable
3n5vB-2o5wA:
undetectable		 3n5vA-2o5wA:
18.71
3n5vB-2o5wA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Y_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 2o5w DATP
PYROPHOSPHOHYDROLASE
(Escherichia
coli) 		4 / 7 ARG A  77
VAL A  15
PHE A 145
GLU A 143
 None
 1.49A 3n5yA-2o5wA:
undetectable
3n5yB-2o5wA:
undetectable		 3n5yA-2o5wA:
18.71
3n5yB-2o5wA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Z_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 2o5w DATP
PYROPHOSPHOHYDROLASE
(Escherichia
coli) 		4 / 7 ARG A  77
VAL A  15
PHE A 145
GLU A 143
 None
 1.49A 3n5zA-2o5wA:
undetectable
3n5zB-2o5wA:
undetectable		 3n5zA-2o5wA:
18.71
3n5zB-2o5wA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2o5w DATP
PYROPHOSPHOHYDROLASE
(Escherichia
coli) 		4 / 7 ARG A  77
VAL A  15
PHE A 145
GLU A 143
 None
 1.48A 4ctrA-2o5wA:
undetectable
4ctrB-2o5wA:
undetectable		 4ctrA-2o5wA:
18.71
4ctrB-2o5wA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSF_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2o5w DATP
PYROPHOSPHOHYDROLASE
(Escherichia
coli) 		4 / 7 ARG A  77
VAL A  15
PHE A 145
GLU A 143
 None
 1.48A 4jsfA-2o5wA:
undetectable
4jsfB-2o5wA:
undetectable		 4jsfA-2o5wA:
18.71
4jsfB-2o5wA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2o5w DATP
PYROPHOSPHOHYDROLASE
(Escherichia
coli) 		4 / 7 ARG A  77
VAL A  15
PHE A 145
GLU A 143
 None
 1.47A 5ad4A-2o5wA:
undetectable
5ad4B-2o5wA:
undetectable		 5ad4A-2o5wA:
18.71
5ad4B-2o5wA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2o5w DATP
PYROPHOSPHOHYDROLASE
(Escherichia
coli) 		4 / 7 ARG A  77
VAL A  15
PHE A 145
GLU A 143
 None
 1.50A 5untA-2o5wA:
undetectable
5untB-2o5wA:
undetectable		 5untA-2o5wA:
18.71
5untB-2o5wA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2o5w DATP
PYROPHOSPHOHYDROLASE
(Escherichia
coli) 		4 / 6 ARG A  77
VAL A  15
PHE A 145
GLU A 143
 None
 1.42A 5unvA-2o5wA:
undetectable
5unvB-2o5wA:
undetectable		 5unvA-2o5wA:
18.71
5unvB-2o5wA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUJ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2o5w DATP
PYROPHOSPHOHYDROLASE
(Escherichia
coli) 		4 / 7 ARG A  77
VAL A  15
PHE A 145
GLU A 143
 None
 1.41A 5vujA-2o5wA:
undetectable
5vujB-2o5wA:
undetectable		 5vujA-2o5wA:
18.71
5vujB-2o5wA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUJ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2o5w DATP
PYROPHOSPHOHYDROLASE
(Escherichia
coli) 		4 / 7 PHE A 145
GLU A 143
ARG A  77
VAL A  15
 None
 1.46A 5vujA-2o5wA:
undetectable
5vujB-2o5wA:
undetectable		 5vujA-2o5wA:
18.71
5vujB-2o5wA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2o5w DATP
PYROPHOSPHOHYDROLASE
(Escherichia
coli) 		4 / 7 ARG A  77
VAL A  15
PHE A 145
GLU A 143
 None
 1.50A 5vuyA-2o5wA:
undetectable
5vuyB-2o5wA:
undetectable		 5vuyA-2o5wA:
20.53
5vuyB-2o5wA:
20.53