SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o69'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN
(Haemophilus
influenzae) 		4 / 7 HIS A 298
LEU A 149
SER A 150
ASP A 155
 None
 0.98A 1ismB-2o69A:
undetectable		 1ismB-2o69A:
22.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NNF_A_EDTA400_0
(IRON-UTILIZATION
PERIPLASMIC PROTEIN)		 2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN
(Haemophilus
influenzae) 		8 / 11 GLU A  57
ARG A 101
SER A 139
ALA A 141
ASN A 175
TYR A 195
TYR A 196
ARG A 262
 None
None
None
None
None
None
FE  A 401 (-4.6A)
None
 0.66A 1nnfA-2o69A:
51.1		 1nnfA-2o69A:
99.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN
(Haemophilus
influenzae) 		4 / 6 ALA A  17
GLU A  21
ILE A   2
LEU A  30
 None
 0.81A 1xvaA-2o69A:
undetectable
1xvaB-2o69A:
undetectable		 1xvaA-2o69A:
24.18
1xvaB-2o69A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN
(Haemophilus
influenzae) 		5 / 12 LEU A  30
GLU A  57
SER A  35
ALA A  12
ALA A 261
 None
 1.18A 2bm9D-2o69A:
undetectable		 2bm9D-2o69A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN
(Haemophilus
influenzae) 		5 / 10 ALA A 231
ALA A 230
LEU A 249
SER A 236
LEU A 233
 None
 1.03A 2bxgB-2o69A:
undetectable		 2bxgB-2o69A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN
(Haemophilus
influenzae) 		3 / 3 VAL A 104
VAL A 182
SER A 211
 None
 0.74A 3n8xB-2o69A:
undetectable		 3n8xB-2o69A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN
(Haemophilus
influenzae) 		3 / 3 ALA A 231
VAL A 232
GLN A 243
 None
 0.68A 3of4B-2o69A:
undetectable		 3of4B-2o69A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN
(Haemophilus
influenzae) 		5 / 12 ASP A 295
ARG A 103
GLY A 154
SER A 150
ALA A 148
 None
 1.18A 3sueD-2o69A:
undetectable		 3sueD-2o69A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN
(Haemophilus
influenzae) 		5 / 11 TYR A 265
GLY A 100
GLY A 229
ALA A  12
ALA A  13
 None
 1.15A 3sufC-2o69A:
undetectable		 3sufC-2o69A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN
(Haemophilus
influenzae) 		3 / 3 ARG A 262
HIS A   9
TYR A 195
 None
 1.06A 4fu8A-2o69A:
undetectable		 4fu8A-2o69A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN
(Haemophilus
influenzae) 		3 / 3 ARG A 262
HIS A   9
TYR A 195
 None
 1.03A 4fu9A-2o69A:
undetectable		 4fu9A-2o69A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN
(Haemophilus
influenzae) 		5 / 12 LEU A  30
LYS A   1
VAL A   4
ALA A  13
LEU A 249
 None
 0.86A 4i1rA-2o69A:
2.2		 4i1rA-2o69A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN
(Haemophilus
influenzae) 		4 / 8 TRP A 129
GLU A 118
MET A 117
VAL A 216
 None
 1.36A 4uchA-2o69A:
undetectable
4uchB-2o69A:
undetectable		 4uchA-2o69A:
22.30
4uchB-2o69A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN
(Haemophilus
influenzae) 		4 / 7 ILE A  74
LEU A  71
ALA A 230
ILE A  96
 None
 0.83A 4y03A-2o69A:
undetectable		 4y03A-2o69A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN
(Haemophilus
influenzae) 		4 / 5 ALA A 263
TYR A 198
PRO A 279
PHE A 215
 None
 1.22A 4ze2A-2o69A:
undetectable		 4ze2A-2o69A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN
(Haemophilus
influenzae) 		6 / 12 GLU A 144
ALA A 285
ALA A 223
VAL A 216
LEU A 283
TYR A 195
 None
 1.49A 5igtA-2o69A:
undetectable		 5igtA-2o69A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN
(Haemophilus
influenzae) 		5 / 12 ASP A   1
ILE A  26
GLU A  23
PHE A  20
GLY A  25
 None
 1.37A 5il1A-2o69A:
undetectable		 5il1A-2o69A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN
(Haemophilus
influenzae) 		5 / 12 ALA A 285
ARG A 103
GLY A 222
MET A 117
GLU A 114
 None
 1.15A 5ul4A-2o69A:
2.6		 5ul4A-2o69A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN
(Haemophilus
influenzae) 		4 / 6 ARG A 103
SER A 102
ALA A 285
ALA A 148
 None
 0.89A 6ma6A-2o69A:
undetectable		 6ma6A-2o69A:
13.84