SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o6i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_A_RIOA500_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 9 ASP A 191
SER A  67
SER A  65
ASP A 111
ASP A 183
 None
None
None
ZN  A 501 (-2.6A)
ZN  A 501 (-2.4A)
 1.47A 1m4gA-2o6iA:
0.0		 1m4gA-2o6iA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_B_RIOB501_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 9 ASP A 191
SER A  67
SER A  65
ASP A 111
ASP A 183
 None
None
None
ZN  A 501 (-2.6A)
ZN  A 501 (-2.4A)
 1.44A 1m4gB-2o6iA:
0.0		 1m4gB-2o6iA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		4 / 8 PHE A  64
SER A  65
LEU A  68
ILE A  24
 None
 0.90A 1sbrA-2o6iA:
undetectable		 1sbrA-2o6iA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 12 ALA A 332
ASN A 365
PHE A 334
LEU A 452
ALA A 451
 None
 1.14A 1xdkA-2o6iA:
undetectable		 1xdkA-2o6iA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 11 LEU A 370
HIS A 114
HIS A 129
ASP A 111
ASP A 183
 None
None
None
ZN  A 501 (-2.6A)
ZN  A 501 (-2.4A)
 1.23A 1zz1A-2o6iA:
undetectable		 1zz1A-2o6iA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 10 LEU A 204
HIS A  21
LEU A 208
ILE A 211
ALA A 182
 None
 1.05A 2bxeB-2o6iA:
undetectable		 2bxeB-2o6iA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		4 / 5 HIS A 114
HIS A 129
ASP A 111
ASP A 183
 None
None
ZN  A 501 (-2.6A)
ZN  A 501 (-2.4A)
 1.15A 3c0zA-2o6iA:
undetectable		 3c0zA-2o6iA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		4 / 6 HIS A 114
HIS A 129
ASP A 111
ASP A 183
 None
None
ZN  A 501 (-2.6A)
ZN  A 501 (-2.4A)
 1.16A 3c0zC-2o6iA:
undetectable		 3c0zC-2o6iA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_2
(GLUCOCORTICOID
RECEPTOR)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 9 LEU A  34
LEU A 108
ALA A  38
GLN A 146
TYR A 145
 None
 1.44A 3cldA-2o6iA:
0.0		 3cldA-2o6iA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		4 / 7 LEU A 188
ASP A 191
ALA A 192
TYR A 239
 None
 0.94A 3rodD-2o6iA:
undetectable		 3rodD-2o6iA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		4 / 4 VAL A  20
PHE A 194
PHE A  56
VAL A 242
 None
 1.19A 3rv5C-2o6iA:
0.0
3rv5D-2o6iA:
0.0		 3rv5C-2o6iA:
10.90
3rv5D-2o6iA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		3 / 3 TYR A 236
LEU A 204
ARG A 235
 None
 0.74A 3sufB-2o6iA:
undetectable		 3sufB-2o6iA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		4 / 7 GLY A  50
PHE A 305
PHE A 323
LEU A 255
 CL  A 503 ( 3.8A)
None
None
None
 0.89A 3v7pA-2o6iA:
undetectable		 3v7pA-2o6iA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_B_ACTB201_0
(RETINOL-BINDING
PROTEIN 2)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		4 / 5 TYR A 239
TYR A 231
GLU A 387
GLN A 179
 None
 1.45A 4qztB-2o6iA:
undetectable		 4qztB-2o6iA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		3 / 3 GLU A  13
TYR A  71
GLU A  72
 None
 0.68A 4ryaA-2o6iA:
undetectable		 4ryaA-2o6iA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		4 / 7 ILE A 218
LYS A 383
GLY A 216
GLY A 217
 None
 0.81A 5a06A-2o6iA:
undetectable		 5a06A-2o6iA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		4 / 7 ILE A 218
LYS A 383
GLY A 216
GLY A 217
 None
 0.79A 5a06C-2o6iA:
undetectable		 5a06C-2o6iA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		4 / 7 ILE A 218
LYS A 383
GLY A 216
GLY A 217
 None
 0.82A 5a06E-2o6iA:
undetectable		 5a06E-2o6iA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		4 / 7 ILE A 218
LYS A 383
GLY A 216
GLY A 217
 None
 0.79A 5a06F-2o6iA:
undetectable		 5a06F-2o6iA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		4 / 5 GLU A 143
THR A 142
HIS A  66
LEU A  43
 None
None
ZN  A 501 (-3.4A)
None
 1.14A 5axaA-2o6iA:
undetectable		 5axaA-2o6iA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		4 / 5 GLU A 143
THR A 142
HIS A  66
LEU A  43
 None
None
ZN  A 501 (-3.4A)
None
 1.12A 5axaC-2o6iA:
undetectable		 5axaC-2o6iA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 12 HIS A 114
HIS A 129
ASP A 111
ASP A 183
TYR A 187
 None
None
ZN  A 501 (-2.6A)
ZN  A 501 (-2.4A)
None
 1.45A 5ef8B-2o6iA:
undetectable		 5ef8B-2o6iA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 12 GLU A  60
LEU A 259
SER A  53
PHE A 323
ARG A 326
 None
 1.34A 5nd2B-2o6iA:
undetectable		 5nd2B-2o6iA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2o6i HD DOMAIN PROTEIN
(Enterococcus
faecalis) 		3 / 3 LYS A 327
LEU A 258
ASP A 318
 None
 0.95A 5zv2A-2o6iA:
undetectable		 5zv2A-2o6iA:
10.49