SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2o6l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7
(Homo
sapiens) 		4 / 6 VAL A 391
GLY A 392
ALA A 428
LEU A 429
 None
 0.80A 1e7bB-2o6lA:
undetectable		 1e7bB-2o6lA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7
(Homo
sapiens) 		5 / 9 PHE A 339
PHE A 307
LEU A 425
MET A 316
LEU A 328
 None
 1.39A 1wrkA-2o6lA:
undetectable
1wrkB-2o6lA:
undetectable		 1wrkA-2o6lA:
22.36
1wrkB-2o6lA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7
(Homo
sapiens) 		4 / 4 LEU A 336
SER A 299
LEU A 288
LEU A 362
 None
 1.05A 1yajA-2o6lA:
1.5		 1yajA-2o6lA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7
(Homo
sapiens) 		4 / 8 TYR A 438
ASN A 441
LYS A 444
GLY A 410
 None
 0.92A 1ykiA-2o6lA:
undetectable
1ykiB-2o6lA:
undetectable		 1ykiA-2o6lA:
21.10
1ykiB-2o6lA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7
(Homo
sapiens) 		4 / 8 TYR A 438
ASN A 441
LYS A 444
GLY A 410
 None
 0.94A 1ykiA-2o6lA:
undetectable
1ykiB-2o6lA:
undetectable		 1ykiA-2o6lA:
21.10
1ykiB-2o6lA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7
(Homo
sapiens) 		4 / 8 TYR A 438
ASN A 441
LYS A 444
GLY A 410
 None
 0.90A 1ykiC-2o6lA:
undetectable
1ykiD-2o6lA:
undetectable		 1ykiC-2o6lA:
21.10
1ykiD-2o6lA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7
(Homo
sapiens) 		4 / 8 TYR A 438
ASN A 441
LYS A 444
GLY A 410
 None
 0.91A 1ykiC-2o6lA:
undetectable
1ykiD-2o6lA:
undetectable		 1ykiC-2o6lA:
21.10
1ykiD-2o6lA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7
(Homo
sapiens) 		4 / 8 GLN A 359
SER A 308
HIS A 374
ARG A 338
 None
 1.02A 3kp6A-2o6lA:
undetectable		 3kp6A-2o6lA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7
(Homo
sapiens) 		5 / 11 ASP A 435
VAL A 413
ALA A 412
SER A 437
GLY A 410
 None
 1.27A 4mm9A-2o6lA:
undetectable		 4mm9A-2o6lA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7
(Homo
sapiens) 		5 / 9 ASP A 435
VAL A 413
ALA A 412
SER A 437
GLY A 410
 None
 1.28A 4mmeA-2o6lA:
undetectable		 4mmeA-2o6lA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7
(Homo
sapiens) 		5 / 9 ASP A 435
VAL A 413
ALA A 412
SER A 437
GLY A 410
 None
 1.29A 4mmeB-2o6lA:
undetectable		 4mmeB-2o6lA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7
(Homo
sapiens) 		5 / 9 ASP A 435
VAL A 413
ALA A 412
SER A 437
GLY A 410
 None
 1.31A 4mmfA-2o6lA:
undetectable		 4mmfA-2o6lA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7
(Homo
sapiens) 		5 / 9 ASP A 435
VAL A 413
ALA A 412
SER A 437
GLY A 410
 None
 1.29A 4mmfB-2o6lA:
undetectable		 4mmfB-2o6lA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7
(Homo
sapiens) 		3 / 3 ASN A 360
VAL A 296
HIS A 365
 None
 0.85A 6a5yD-2o6lA:
undetectable		 6a5yD-2o6lA:
19.30